HSPA8

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW

Keywordsⁱ

Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Ligand

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Heat shock cognate 71 kDa proteinImported Submitted name: cDNA FLJ77848Imported
Gene namesⁱ	Name:HSPA8Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

HGNCⁱ

HGNC:5241. HSPA8.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000109971.

OpenTargetsⁱ

ENSG00000109971.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	A8K7Q2.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A8K7Q2.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000109971.
ExpressionAtlasⁱ	A8K7Q2. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	A8K7Q2. 8 interactors.

IntActⁱ

A8K7Q2. 8 interactors.

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	276 – 299	Sequence analysisAdd BLAST		24

Sequence similaritiesⁱ

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0101. Eukaryota. COG0443. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139357.
HOVERGENⁱ	HBG051845.

Family and domain databases

Gene3Dⁱ	1.20.1270.10. 1 hit. 2.60.34.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018181. Heat_shock_70_CS. IPR029048. HSP70_C. IPR029047. HSP70_peptide-bd. IPR013126. Hsp_70_fam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012. HSP70. 1 hit.
PRINTSⁱ	PR00301. HEATSHOCK70.
SUPFAMⁱ	SSF100920. SSF100920. 1 hit. SSF100934. SSF100934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01036. HSP70_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A8K7Q2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVNHFIAEFK RKHKKDISEN KRAVRRLRTA CERAKRTLSS STQASIEIDS 
        60         70         80         90        100
LYEGIDFYTS ITRARFEELN ADLFRGTLDP VEKALRDAKL DKSQIHDIVL 
       110        120        130        140        150
VGGSTRIPKI QKLLQDFFNG KELNKSINPD EAVAYGAAVQ AAILSGDKSE 
       160        170        180        190        200
NVQDLLLLDV TPLSLGIETA GGVMTVLIKR NTTIPTKQTQ TFTTYSDNQP 
       210        220        230        240        250
GVLIQVYEGE RAMTKDNNLL GKFELTGIPP APRGVPQIEV TFDIDANGIL 
       260        270        280        290        300
NVSAVDKSTG KENKITITND KGRLSKEDIE RMVQEAEKYK AEDEKQRDKV 
       310        320        330        340        350
SSKNSLESYA FNMKATVEDE KLQGKINDED KQKILDKCNE IINWLDKNQT 
       360        370        380        390        400
AEKEEFEHQQ KELEKVCNPI ITKLYQSAGG MPGGMPGGFP GGGAPPSGGA 
       410
SSGPTIEEVD

Length:410

Mass (Da):45,338

Last modified:December 4, 2007 - v1

Checksum:ⁱ1BE1D9961D811469

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP000926 Genomic DNA. No translation available. AK292067 mRNA. Translation: BAF84756.1.
UniGeneⁱ	Hs.180414.

Genome annotation databases

Ensemblⁱ	ENST00000534319; ENSP00000433316; ENSG00000109971.
UCSC genome browser More...UCSCⁱ	uc009zbc.4. human.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A8K7Q2	P11142 A2Q0Z1 Q71U34 V9HW22 D2GYC0 Q5RA83 E2R0T6 I0FRC9 G3RYM8 A0A0D9S441 +39	Homo sapiens (Human) Equus caballus (Horse) Saguinus oedipus (Cotton-top tamarin) Ailuropoda melanoleuca (Giant panda) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Canis lupus familiaris (Dog) (Canis familiaris) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinolophus ferrumequinum (Greater horseshoe bat) And more	646	UniRef100_P11142	Cluster: Heat shock cognate 71 kDa protein	50

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A8K7Q2	P11142 A2Q0Z1 Q71U34 V9HW22 D2GYC0 Q5RA83 E2R0T6 I0FRC9 G3RYM8 A0A0D9S441 +39	Homo sapiens (Human) Equus caballus (Horse) Saguinus oedipus (Cotton-top tamarin) Ailuropoda melanoleuca (Giant panda) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Canis lupus familiaris (Dog) (Canis familiaris) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinolophus ferrumequinum (Greater horseshoe bat) And more	646	UniRef90_P11142	Cluster: Heat shock cognate 71 kDa protein	50

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A8K7Q2	P0DMV8 P0DMV9 Q5R7D3 A8K5I0 G7MRK7 G3QSK4 G8F3W4 A0A0D9SD81 UPI00083EF80D UPI00059B2317 +109	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Ailuropoda melanoleuca (Giant panda) Capra hircus (Goat) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) And more	641	UniRef50_P0DMV8	Cluster: Heat shock 70 kDa protein 1A	120

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP000926 Genomic DNA. No translation available. AK292067 mRNA. Translation: BAF84756.1.
UniGeneⁱ	Hs.180414.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	A8K7Q2. 8 interactors.

IntActⁱ

A8K7Q2. 8 interactors.

Proteomic databases

EPDⁱ	A8K7Q2.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A8K7Q2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000534319; ENSP00000433316; ENSG00000109971.
UCSC genome browser More...UCSCⁱ	uc009zbc.4. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5241. HSPA8.
Open Targets More...OpenTargetsⁱ	ENSG00000109971.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0101. Eukaryota. COG0443. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139357.
HOVERGENⁱ	HBG051845.

Miscellaneous databases

ChiTaRSⁱ	HSPA8. human.

ChiTaRSⁱ

HSPA8. human.

Gene expression databases

Bgeeⁱ	ENSG00000109971.
ExpressionAtlasⁱ	A8K7Q2. baseline and differential.

Family and domain databases

Gene3Dⁱ	1.20.1270.10. 1 hit. 2.60.34.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018181. Heat_shock_70_CS. IPR029048. HSP70_C. IPR029047. HSP70_peptide-bd. IPR013126. Hsp_70_fam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012. HSP70. 1 hit.
PRINTSⁱ	PR00301. HEATSHOCK70.
SUPFAMⁱ	SSF100920. SSF100920. 1 hit. SSF100934. SSF100934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01036. HSP70_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8K7Q2_HUMAN
Accessionⁱ	A8K7Q2Primary (citable) accession number: A8K7Q2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	August 30, 2017
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A8K7Q2 (A8K7Q2_HUMAN)

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Heat shock cognate 71 kDa protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ