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UniProtKB - A8K7Q2 (A8K7Q2_HUMAN)

UniProt

A8K7Q2 - A8K7Q2_HUMAN

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Protein
Submitted name:

Heat shock cognate 71 kDa protein

Gene

HSPA8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock cognate 71 kDa proteinImported
Submitted name:
cDNA FLJ77848Imported
Gene namesi
Name:HSPA8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5241. HSPA8.

PTM / Processingi

Proteomic databases

EPDiA8K7Q2.
MaxQBiA8K7Q2.
PeptideAtlasiA8K7Q2.

Expressioni

Gene expression databases

BgeeiENSG00000109971.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000227378.

Structurei

3D structure databases

SMRiA8K7Q2. Positions 1-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili276 – 29924Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOVERGENiHBG051845.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K7Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNHFIAEFK RKHKKDISEN KRAVRRLRTA CERAKRTLSS STQASIEIDS 
        60         70         80         90        100
LYEGIDFYTS ITRARFEELN ADLFRGTLDP VEKALRDAKL DKSQIHDIVL 
       110        120        130        140        150
VGGSTRIPKI QKLLQDFFNG KELNKSINPD EAVAYGAAVQ AAILSGDKSE 
       160        170        180        190        200
NVQDLLLLDV TPLSLGIETA GGVMTVLIKR NTTIPTKQTQ TFTTYSDNQP 
       210        220        230        240        250
GVLIQVYEGE RAMTKDNNLL GKFELTGIPP APRGVPQIEV TFDIDANGIL 
       260        270        280        290        300
NVSAVDKSTG KENKITITND KGRLSKEDIE RMVQEAEKYK AEDEKQRDKV 
       310        320        330        340        350
SSKNSLESYA FNMKATVEDE KLQGKINDED KQKILDKCNE IINWLDKNQT 
       360        370        380        390        400
AEKEEFEHQQ KELEKVCNPI ITKLYQSAGG MPGGMPGGFP GGGAPPSGGA 
       410
SSGPTIEEVD
Length:410
Mass (Da):45,338
Last modified:December 4, 2007 - v1
Checksum:i1BE1D9961D811469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000926 Genomic DNA. No translation available.
AK292067 mRNA. Translation: BAF84756.1.
UniGeneiHs.180414.

Genome annotation databases

EnsembliENST00000534319; ENSP00000433316; ENSG00000109971.
UCSCiuc009zbc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000926 Genomic DNA. No translation available.
AK292067 mRNA. Translation: BAF84756.1.
UniGeneiHs.180414.

3D structure databases

SMRiA8K7Q2. Positions 1-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000227378.

Proteomic databases

EPDiA8K7Q2.
MaxQBiA8K7Q2.
PeptideAtlasiA8K7Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000534319; ENSP00000433316; ENSG00000109971.
UCSCiuc009zbc.4. human.

Organism-specific databases

HGNCiHGNC:5241. HSPA8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOVERGENiHBG051845.

Miscellaneous databases

ChiTaRSiHSPA8. human.

Gene expression databases

BgeeiENSG00000109971.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K7Q2_HUMAN
AccessioniPrimary (citable) accession number: A8K7Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.