Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8K7I4

- CLCA1_HUMAN

UniProt

A8K7I4 - CLCA1_HUMAN

Protein

Calcium-activated chloride channel regulator 1

Gene

CLCA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.4 Publications

    GO - Molecular functioni

    1. chloride channel activity Source: ProtInc

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB-KW
    2. cellular response to hypoxia Source: Ensembl
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: GOC
    5. transport Source: ProtInc

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Chloride

    Protein family/group databases

    MEROPSiM87.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated chloride channel regulator 1
    Alternative name(s):
    Calcium-activated chloride channel family member 1
    Short name:
    hCLCA1
    Calcium-activated chloride channel protein 1
    Short name:
    CaCC-1
    Short name:
    hCaCC-1
    Gene namesi
    Name:CLCA1
    Synonyms:CACC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2015. CLCA1.

    Subcellular locationi

    Secretedextracellular space 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Extracellular side 1 Publication
    Note: Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. zymogen granule membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26542.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 914893Calcium-activated chloride channel regulator 1PRO_0000333690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi810 – 8101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi831 – 8311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi836 – 8361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.1 Publication
    The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiA8K7I4.
    PRIDEiA8K7I4.

    PTM databases

    PhosphoSiteiA8K7I4.

    Expressioni

    Tissue specificityi

    Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.5 Publications

    Inductioni

    By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa.7 Publications

    Gene expression databases

    BgeeiA8K7I4.
    CleanExiHS_CLCA1.
    GenevestigatoriA8K7I4.

    Organism-specific databases

    HPAiHPA052787.

    Interactioni

    Protein-protein interaction databases

    BioGridi107593. 2 interactions.
    IntActiA8K7I4. 1 interaction.
    STRINGi9606.ENSP00000234701.

    Structurei

    3D structure databases

    ProteinModelPortaliA8K7I4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini306 – 475170VWFAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CLCR family.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42884.
    HOGENOMiHOG000015107.
    HOVERGENiHBG005560.
    InParanoidiA8K7I4.
    KOiK05027.
    OMAiEPYTEQM.
    OrthoDBiEOG78WKR1.
    PhylomeDBiA8K7I4.
    TreeFamiTF328396.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004727. CaCC_prot.
    IPR013642. Cl_channel_Ca.
    IPR015394. DUF1973.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF08434. CLCA_N. 1 hit.
    PF09315. DUF1973. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    TIGRFAMsiTIGR00868. hCaCC. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8K7I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPFKSSVFI LILHLLEGAL SNSLIQLNNN GYEGIVVAID PNVPEDETLI    50
    QQIKDMVTQA SLYLLEATGK RFYFKNVAIL IPETWKTKAD YVRPKLETYK 100
    NADVLVAEST PPGNDEPYTE QMGNCGEKGE RIHLTPDFIA GKKLAEYGPQ 150
    GRAFVHEWAH LRWGVFDEYN NDEKFYLSNG RIQAVRCSAG ITGTNVVKKC 200
    QGGSCYTKRC TFNKVTGLYE KGCEFVLQSR QTEKASIMFA QHVDSIVEFC 250
    TEQNHNKEAP NKQNQKCNLR STWEVIRDSE DFKKTTPMTT QPPNPTFSLL 300
    QIGQRIVCLV LDKSGSMATG NRLNRLNQAG QLFLLQTVEL GSWVGMVTFD 350
    SAAHVQNELI QINSGSDRDT LAKRLPAAAS GGTSICSGLR SAFTVIRKKY 400
    PTDGSEIVLL TDGEDNTISG CFNEVKQSGA IIHTVALGPS AAQELEELSK 450
    MTGGLQTYAS DQVQNNGLID AFGALSSGNG AVSQRSIQLE SKGLTLQNSQ 500
    WMNGTVIVDS TVGKDTLFLI TWTMQPPQIL LWDPSGQKQG GFVVDKNTKM 550
    AYLQIPGIAK VGTWKYSLQA SSQTLTLTVT SRASNATLPP ITVTSKTNKD 600
    TSKFPSPLVV YANIRQGASP ILRASVTALI ESVNGKTVTL ELLDNGAGAD 650
    ATKDDGVYSR YFTTYDTNGR YSVKVRALGG VNAARRRVIP QQSGALYIPG 700
    WIENDEIQWN PPRPEINKDD VQHKQVCFSR TSSGGSFVAS DVPNAPIPDL 750
    FPPGQITDLK AEIHGGSLIN LTWTAPGDDY DHGTAHKYII RISTSILDLR 800
    DKFNESLQVN TTALIPKEAN SEEVFLFKPE NITFENGTDL FIAIQAVDKV 850
    DLKSEISNIA RVSLFIPPQT PPETPSPDET SAPCPNIHIN STIPGIHILK 900
    IMWKWIGELQ LSIA 914
    Length:914
    Mass (Da):100,226
    Last modified:November 2, 2010 - v3
    Checksum:i8D8999E855822711
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti393 – 3931F → S in BAF84688. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651L → F.4 Publications
    Corresponds to variant rs2145412 [ dbSNP | Ensembl ].
    VAR_054654
    Natural varianti152 – 1521R → K.1 Publication
    Corresponds to variant rs2753386 [ dbSNP | Ensembl ].
    VAR_054655
    Natural varianti357 – 3571N → S.4 Publications
    Corresponds to variant rs2734705 [ dbSNP | Ensembl ].
    VAR_043146
    Natural varianti406 – 4061E → V.
    Corresponds to variant rs1142185 [ dbSNP | Ensembl ].
    VAR_054656
    Natural varianti426 – 4261K → R.
    Corresponds to variant rs4647852 [ dbSNP | Ensembl ].
    VAR_054657
    Natural varianti524 – 5241M → T.4 Publications
    Corresponds to variant rs2791494 [ dbSNP | Ensembl ].
    VAR_043147
    Natural varianti661 – 6611Y → H.
    Corresponds to variant rs5744409 [ dbSNP | Ensembl ].
    VAR_054658
    Natural varianti760 – 7601K → N.1 Publication
    Corresponds to variant rs2791483 [ dbSNP | Ensembl ].
    VAR_054659

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039400 mRNA. Translation: AAC95428.1.
    AF039401 Genomic DNA. Translation: AAC95429.1.
    AF127036 mRNA. Translation: AAD25487.1.
    AK291999 mRNA. Translation: BAF84688.1.
    AK314375 mRNA. Translation: BAG37002.1.
    AL122002 Genomic DNA. Translation: CAI22169.1.
    CH471097 Genomic DNA. Translation: EAW73186.1.
    CCDSiCCDS709.1.
    RefSeqiNP_001276.2. NM_001285.3.
    UniGeneiHs.194659.

    Genome annotation databases

    EnsembliENST00000234701; ENSP00000234701; ENSG00000016490.
    ENST00000394711; ENSP00000378200; ENSG00000016490.
    GeneIDi1179.
    KEGGihsa:1179.
    UCSCiuc001dls.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039400 mRNA. Translation: AAC95428.1 .
    AF039401 Genomic DNA. Translation: AAC95429.1 .
    AF127036 mRNA. Translation: AAD25487.1 .
    AK291999 mRNA. Translation: BAF84688.1 .
    AK314375 mRNA. Translation: BAG37002.1 .
    AL122002 Genomic DNA. Translation: CAI22169.1 .
    CH471097 Genomic DNA. Translation: EAW73186.1 .
    CCDSi CCDS709.1.
    RefSeqi NP_001276.2. NM_001285.3.
    UniGenei Hs.194659.

    3D structure databases

    ProteinModelPortali A8K7I4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107593. 2 interactions.
    IntActi A8K7I4. 1 interaction.
    STRINGi 9606.ENSP00000234701.

    Chemistry

    ChEMBLi CHEMBL2364708.

    Protein family/group databases

    MEROPSi M87.001.

    PTM databases

    PhosphoSitei A8K7I4.

    Proteomic databases

    PaxDbi A8K7I4.
    PRIDEi A8K7I4.

    Protocols and materials databases

    DNASUi 1179.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234701 ; ENSP00000234701 ; ENSG00000016490 .
    ENST00000394711 ; ENSP00000378200 ; ENSG00000016490 .
    GeneIDi 1179.
    KEGGi hsa:1179.
    UCSCi uc001dls.1. human.

    Organism-specific databases

    CTDi 1179.
    GeneCardsi GC01P086934.
    HGNCi HGNC:2015. CLCA1.
    HPAi HPA052787.
    MIMi 603906. gene.
    neXtProti NX_A8K7I4.
    PharmGKBi PA26542.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42884.
    HOGENOMi HOG000015107.
    HOVERGENi HBG005560.
    InParanoidi A8K7I4.
    KOi K05027.
    OMAi EPYTEQM.
    OrthoDBi EOG78WKR1.
    PhylomeDBi A8K7I4.
    TreeFami TF328396.

    Miscellaneous databases

    GeneWikii CLCA1.
    GenomeRNAii 1179.
    NextBioi 4872.
    PROi A8K7I4.
    SOURCEi Search...

    Gene expression databases

    Bgeei A8K7I4.
    CleanExi HS_CLCA1.
    Genevestigatori A8K7I4.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004727. CaCC_prot.
    IPR013642. Cl_channel_Ca.
    IPR015394. DUF1973.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF08434. CLCA_N. 1 hit.
    PF09315. DUF1973. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    TIGRFAMsi TIGR00868. hCaCC. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins."
      Gruber A.D., Elble R.C., Ji H.-L., Schreur K.D., Fuller C.M., Pauli B.U.
      Genomics 54:200-214(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION, PROTEOLYTIC PROCESSING, VARIANTS PHE-65; LYS-152; SER-357; THR-524 AND ASN-760.
      Tissue: Small intestine.
    2. "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea."
      Agnel M., Vermat T., Culouscou J.-M.
      FEBS Lett. 455:295-301(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-65; SER-357 AND THR-524.
      Tissue: Small intestine.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-65; SER-357 AND THR-524.
      Tissue: Colon and Small intestine.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-65; SER-357 AND THR-524.
    6. "Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer."
      Bustin S.A., Li S.-R., Dorudi S.
      DNA Cell Biol. 20:331-338(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    7. "Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway."
      Hoshino M., Morita S., Iwashita H., Sagiya Y., Nagi T., Nakanishi A., Ashida Y., Nishimura O., Fujisawa Y., Fujino M.
      Am. J. Respir. Crit. Care Med. 165:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    8. "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma."
      Toda M., Tulic M.K., Levitt R.C., Hamid Q.
      J. Allergy Clin. Immunol. 109:246-250(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    9. "Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps."
      Lee S.H., Park J.H., Jung H.H., Lee S.H., Oh J.W., Lee H.M., Jun H.S., Cho W.J., Lee J.Y.
      Acta Oto-Laryngol. 125:745-752(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    10. "Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa."
      Hauber H.-P., Daigneault P., Frenkiel S., Lavigne F., Hung H.-L., Levitt R.C., Hamid Q.
      J. Allergy Clin. Immunol. 115:266-271(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels."
      Gibson A., Lewis A.P., Affleck K., Aitken A.J., Meldrum E., Thompson N.
      J. Biol. Chem. 280:27205-27212(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium."
      Thai P., Chen Y., Dolganov G., Wu R.
      Am. J. Respir. Cell Mol. Biol. 33:523-530(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    13. "Histamine induces MUC5AC expression via a hCLCA1 pathway."
      Kim Y.M., Won T.-B., Kim S.W., Min Y.-G., Lee C.H., Rhee C.-S.
      Pharmacology 80:219-226(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCLCA1_HUMAN
    AccessioniPrimary (citable) accession number: A8K7I4
    Secondary accession number(s): B2RAV5
    , O95151, Q5TDF4, Q9UNF6, Q9UPC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 59 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3