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A8K7I4

- CLCA1_HUMAN

UniProt

A8K7I4 - CLCA1_HUMAN

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Protein

Calcium-activated chloride channel regulator 1

Gene

CLCA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi156 – 1561Zinc1 Publication
Metal bindingi160 – 1601Zinc1 Publication
Metal bindingi167 – 1671Zinc1 Publication
Sitei694 – 6952Cleavage; by autoproteolysis1 Publication

GO - Molecular functioni

  1. chloride channel activity Source: ProtInc

GO - Biological processi

  1. calcium ion transport Source: UniProtKB-KW
  2. cellular response to hypoxia Source: Ensembl
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: GOC
  5. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride, Metal-binding, Zinc

Protein family/group databases

MEROPSiM87.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated chloride channel regulator 1 (EC:3.4.-.-1 Publication)
Alternative name(s):
Calcium-activated chloride channel family member 1
Short name:
hCLCA1
Calcium-activated chloride channel protein 1
Short name:
CaCC-1
Short name:
hCaCC-1
Gene namesi
Name:CLCA1
Synonyms:CACC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2015. CLCA1.

Subcellular locationi

Secretedextracellular space 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Extracellular side 1 Publication
Note: Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. microvillus Source: Ensembl
  4. zymogen granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi156 – 1561H → A: Abolishes proteolytic cleavage. 1 Publication
Mutagenesisi157 – 1571E → Q: Abolishes proteolytic cleavage. 1 Publication

Organism-specific databases

PharmGKBiPA26542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 914893Calcium-activated chloride channel regulator 1PRO_0000333690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi810 – 8101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi831 – 8311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi836 – 8361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.1 Publication
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.2 Publications

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein

Proteomic databases

PaxDbiA8K7I4.
PRIDEiA8K7I4.

PTM databases

PhosphoSiteiA8K7I4.

Expressioni

Tissue specificityi

Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.5 Publications

Inductioni

By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa.7 Publications

Gene expression databases

BgeeiA8K7I4.
CleanExiHS_CLCA1.
GenevestigatoriA8K7I4.

Organism-specific databases

HPAiHPA052787.

Interactioni

Protein-protein interaction databases

BioGridi107593. 2 interactions.
IntActiA8K7I4. 1 interaction.
STRINGi9606.ENSP00000234701.

Structurei

3D structure databases

ProteinModelPortaliA8K7I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 475170VWFAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 199154Metalloprotease domain1 PublicationAdd
BLAST

Domaini

The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates.1 Publication

Sequence similaritiesi

Belongs to the CLCR family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42884.
GeneTreeiENSGT00390000004810.
HOGENOMiHOG000015107.
HOVERGENiHBG005560.
InParanoidiA8K7I4.
KOiK05027.
OMAiEPYTEQM.
OrthoDBiEOG78WKR1.
PhylomeDBiA8K7I4.
TreeFamiTF328396.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00868. hCaCC. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8K7I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPFKSSVFI LILHLLEGAL SNSLIQLNNN GYEGIVVAID PNVPEDETLI
60 70 80 90 100
QQIKDMVTQA SLYLLEATGK RFYFKNVAIL IPETWKTKAD YVRPKLETYK
110 120 130 140 150
NADVLVAEST PPGNDEPYTE QMGNCGEKGE RIHLTPDFIA GKKLAEYGPQ
160 170 180 190 200
GRAFVHEWAH LRWGVFDEYN NDEKFYLSNG RIQAVRCSAG ITGTNVVKKC
210 220 230 240 250
QGGSCYTKRC TFNKVTGLYE KGCEFVLQSR QTEKASIMFA QHVDSIVEFC
260 270 280 290 300
TEQNHNKEAP NKQNQKCNLR STWEVIRDSE DFKKTTPMTT QPPNPTFSLL
310 320 330 340 350
QIGQRIVCLV LDKSGSMATG NRLNRLNQAG QLFLLQTVEL GSWVGMVTFD
360 370 380 390 400
SAAHVQNELI QINSGSDRDT LAKRLPAAAS GGTSICSGLR SAFTVIRKKY
410 420 430 440 450
PTDGSEIVLL TDGEDNTISG CFNEVKQSGA IIHTVALGPS AAQELEELSK
460 470 480 490 500
MTGGLQTYAS DQVQNNGLID AFGALSSGNG AVSQRSIQLE SKGLTLQNSQ
510 520 530 540 550
WMNGTVIVDS TVGKDTLFLI TWTMQPPQIL LWDPSGQKQG GFVVDKNTKM
560 570 580 590 600
AYLQIPGIAK VGTWKYSLQA SSQTLTLTVT SRASNATLPP ITVTSKTNKD
610 620 630 640 650
TSKFPSPLVV YANIRQGASP ILRASVTALI ESVNGKTVTL ELLDNGAGAD
660 670 680 690 700
ATKDDGVYSR YFTTYDTNGR YSVKVRALGG VNAARRRVIP QQSGALYIPG
710 720 730 740 750
WIENDEIQWN PPRPEINKDD VQHKQVCFSR TSSGGSFVAS DVPNAPIPDL
760 770 780 790 800
FPPGQITDLK AEIHGGSLIN LTWTAPGDDY DHGTAHKYII RISTSILDLR
810 820 830 840 850
DKFNESLQVN TTALIPKEAN SEEVFLFKPE NITFENGTDL FIAIQAVDKV
860 870 880 890 900
DLKSEISNIA RVSLFIPPQT PPETPSPDET SAPCPNIHIN STIPGIHILK
910
IMWKWIGELQ LSIA
Length:914
Mass (Da):100,226
Last modified:November 2, 2010 - v3
Checksum:i8D8999E855822711
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3931F → S in BAF84688. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651L → F.4 Publications
Corresponds to variant rs2145412 [ dbSNP | Ensembl ].
VAR_054654
Natural varianti152 – 1521R → K.1 Publication
Corresponds to variant rs2753386 [ dbSNP | Ensembl ].
VAR_054655
Natural varianti357 – 3571N → S.4 Publications
Corresponds to variant rs2734705 [ dbSNP | Ensembl ].
VAR_043146
Natural varianti406 – 4061E → V.
Corresponds to variant rs1142185 [ dbSNP | Ensembl ].
VAR_054656
Natural varianti426 – 4261K → R.
Corresponds to variant rs4647852 [ dbSNP | Ensembl ].
VAR_054657
Natural varianti524 – 5241M → T.4 Publications
Corresponds to variant rs2791494 [ dbSNP | Ensembl ].
VAR_043147
Natural varianti661 – 6611Y → H.
Corresponds to variant rs5744409 [ dbSNP | Ensembl ].
VAR_054658
Natural varianti760 – 7601K → N.1 Publication
Corresponds to variant rs2791483 [ dbSNP | Ensembl ].
VAR_054659

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039400 mRNA. Translation: AAC95428.1.
AF039401 Genomic DNA. Translation: AAC95429.1.
AF127036 mRNA. Translation: AAD25487.1.
AK291999 mRNA. Translation: BAF84688.1.
AK314375 mRNA. Translation: BAG37002.1.
AL122002 Genomic DNA. Translation: CAI22169.1.
CH471097 Genomic DNA. Translation: EAW73186.1.
CCDSiCCDS709.1.
RefSeqiNP_001276.2. NM_001285.3.
UniGeneiHs.194659.

Genome annotation databases

EnsembliENST00000234701; ENSP00000234701; ENSG00000016490.
ENST00000394711; ENSP00000378200; ENSG00000016490.
GeneIDi1179.
KEGGihsa:1179.
UCSCiuc001dls.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039400 mRNA. Translation: AAC95428.1 .
AF039401 Genomic DNA. Translation: AAC95429.1 .
AF127036 mRNA. Translation: AAD25487.1 .
AK291999 mRNA. Translation: BAF84688.1 .
AK314375 mRNA. Translation: BAG37002.1 .
AL122002 Genomic DNA. Translation: CAI22169.1 .
CH471097 Genomic DNA. Translation: EAW73186.1 .
CCDSi CCDS709.1.
RefSeqi NP_001276.2. NM_001285.3.
UniGenei Hs.194659.

3D structure databases

ProteinModelPortali A8K7I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107593. 2 interactions.
IntActi A8K7I4. 1 interaction.
STRINGi 9606.ENSP00000234701.

Chemistry

ChEMBLi CHEMBL2364708.

Protein family/group databases

MEROPSi M87.001.

PTM databases

PhosphoSitei A8K7I4.

Proteomic databases

PaxDbi A8K7I4.
PRIDEi A8K7I4.

Protocols and materials databases

DNASUi 1179.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234701 ; ENSP00000234701 ; ENSG00000016490 .
ENST00000394711 ; ENSP00000378200 ; ENSG00000016490 .
GeneIDi 1179.
KEGGi hsa:1179.
UCSCi uc001dls.1. human.

Organism-specific databases

CTDi 1179.
GeneCardsi GC01P086934.
HGNCi HGNC:2015. CLCA1.
HPAi HPA052787.
MIMi 603906. gene.
neXtProti NX_A8K7I4.
PharmGKBi PA26542.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42884.
GeneTreei ENSGT00390000004810.
HOGENOMi HOG000015107.
HOVERGENi HBG005560.
InParanoidi A8K7I4.
KOi K05027.
OMAi EPYTEQM.
OrthoDBi EOG78WKR1.
PhylomeDBi A8K7I4.
TreeFami TF328396.

Miscellaneous databases

GeneWikii CLCA1.
GenomeRNAii 1179.
NextBioi 4872.
PROi A8K7I4.
SOURCEi Search...

Gene expression databases

Bgeei A8K7I4.
CleanExi HS_CLCA1.
Genevestigatori A8K7I4.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
TIGRFAMsi TIGR00868. hCaCC. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins."
    Gruber A.D., Elble R.C., Ji H.-L., Schreur K.D., Fuller C.M., Pauli B.U.
    Genomics 54:200-214(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION, PROTEOLYTIC PROCESSING, VARIANTS PHE-65; LYS-152; SER-357; THR-524 AND ASN-760.
    Tissue: Small intestine.
  2. "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea."
    Agnel M., Vermat T., Culouscou J.-M.
    FEBS Lett. 455:295-301(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-65; SER-357 AND THR-524.
    Tissue: Small intestine.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-65; SER-357 AND THR-524.
    Tissue: Colon and Small intestine.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-65; SER-357 AND THR-524.
  6. "Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation."
    Yurtsever Z., Sala-Rabanal M., Randolph D.T., Scheaffer S.M., Roswit W.T., Alevy Y.G., Patel A.C., Heier R.F., Romero A.G., Nichols C.G., Holtzman M.J., Brett T.J.
    J. Biol. Chem. 287:42138-42149(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 695-699, FUNCTION, METALLOPROTEASE DOMAIN, PROTEOLYTIC PROCESSING, MUTAGENESIS OF HIS-156 AND GLU-157.
  7. "Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer."
    Bustin S.A., Li S.-R., Dorudi S.
    DNA Cell Biol. 20:331-338(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  8. "Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway."
    Hoshino M., Morita S., Iwashita H., Sagiya Y., Nagi T., Nakanishi A., Ashida Y., Nishimura O., Fujisawa Y., Fujino M.
    Am. J. Respir. Crit. Care Med. 165:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  9. "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma."
    Toda M., Tulic M.K., Levitt R.C., Hamid Q.
    J. Allergy Clin. Immunol. 109:246-250(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  10. "Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps."
    Lee S.H., Park J.H., Jung H.H., Lee S.H., Oh J.W., Lee H.M., Jun H.S., Cho W.J., Lee J.Y.
    Acta Oto-Laryngol. 125:745-752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  11. "Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa."
    Hauber H.-P., Daigneault P., Frenkiel S., Lavigne F., Hung H.-L., Levitt R.C., Hamid Q.
    J. Allergy Clin. Immunol. 115:266-271(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels."
    Gibson A., Lewis A.P., Affleck K., Aitken A.J., Meldrum E., Thompson N.
    J. Biol. Chem. 280:27205-27212(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium."
    Thai P., Chen Y., Dolganov G., Wu R.
    Am. J. Respir. Cell Mol. Biol. 33:523-530(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  14. "Histamine induces MUC5AC expression via a hCLCA1 pathway."
    Kim Y.M., Won T.-B., Kim S.W., Min Y.-G., Lee C.H., Rhee C.-S.
    Pharmacology 80:219-226(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCLCA1_HUMAN
AccessioniPrimary (citable) accession number: A8K7I4
Secondary accession number(s): B2RAV5
, O95151, Q5TDF4, Q9UNF6, Q9UPC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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