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Protein
Submitted name:

Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform

Gene

PPP2R1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoformImported
Submitted name:
Testicular secretory protein Li 1Imported
Submitted name:
cDNA FLJ78455, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNAImported
Submitted name:
cDNA, FLJ96799, Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNAImported
Gene namesi
Name:PPP2R1AImported
ORF Names:hCG_19686Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105568.17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33666.

Expressioni

Gene expression databases

BgeeiENSG00000105568.
ExpressionAtlasiA8K7B7. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSDC2Q9Y5345EBI-10174513,EBI-1763657

Protein-protein interaction databases

IntActiA8K7B7. 1 interactor.

Structurei

3D structure databases

SMRiA8K7B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 50HEATPROSITE-ProRule annotationAdd BLAST39
Repeati89 – 127HEATPROSITE-ProRule annotationAdd BLAST39
Repeati166 – 204HEATPROSITE-ProRule annotationAdd BLAST39
Repeati205 – 243HEATPROSITE-ProRule annotationAdd BLAST39
Repeati244 – 282HEATPROSITE-ProRule annotationAdd BLAST39
Repeati283 – 320HEATPROSITE-ProRule annotationAdd BLAST38
Repeati326 – 364HEATPROSITE-ProRule annotationAdd BLAST39
Repeati365 – 403HEATPROSITE-ProRule annotationAdd BLAST39
Repeati404 – 442HEATPROSITE-ProRule annotationAdd BLAST39
Repeati521 – 559HEATPROSITE-ProRule annotationAdd BLAST39
Repeati560 – 589HEATPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

eggNOGiKOG0211. Eukaryota.
ENOG410XQVI. LUCA.
HOVERGENiHBG000011.
KOiK03456.
OMAiWAQNTVI.
OrthoDBiEOG091G045V.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR031090. PP2A_A_meta.
PANTHERiPTHR10648:SF16. PTHR10648:SF16. 1 hit.
PfamiView protein in Pfam
PF02985. HEAT. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50077. HEAT_REPEAT. 11 hits.

Sequencei

Sequence statusi: Complete.

A8K7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE
60 70 80 90 100
LLPFLTDTIY DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE
110 120 130 140 150
ETVVRDKAVE SLRAISHEHS PSDLEAHFVP LVKRLAGGDW FTSRTSACGL
160 170 180 190 200
FSVCYPRVSS AVKAELRQYF RNLCSDDTPM VRRAAASKLG EFAKVLELDN
210 220 230 240 250
VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL EALVMPTLRQ
260 270 280 290 300
AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA
310 320 330 340 350
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM
360 370 380 390 400
GLSPILGKDN TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL
410 420 430 440 450
SQSLLPAIVE LAEDAKWRVR LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW
460 470 480 490 500
LVDHVYAIRE AATSNLKKLV EKFGKEWAHA TIIPKVLAMS GDPNYLHRMT
510 520 530 540 550
TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV AKSLQKIGPI
560 570 580
LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA
Length:589
Mass (Da):65,309
Last modified:December 4, 2007 - v1
Checksum:i5174EBE94D537836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM005541 mRNA. Translation: AEE61138.1.
AK291932 mRNA. Translation: BAF84621.1.
AK315700 mRNA. Translation: BAG38062.1.
CH471135 Genomic DNA. Translation: EAW72066.1.
RefSeqiNP_055040.2. NM_014225.5.
UniGeneiHs.467192.

Genome annotation databases

GeneIDi5518.
KEGGihsa:5518.

Similar proteinsi

Entry informationi

Entry nameiA8K7B7_HUMAN
AccessioniPrimary (citable) accession number: A8K7B7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.