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Protein
Submitted name:

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Pleckstrin homology domain-containing family A member 2Imported
Submitted name:
cDNA FLJ75843, highly similar to Homo sapiens pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (PLEKHA2), mRNAImported
Gene namesi
Name:PLEKHA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14336. PLEKHA2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33402.

PTM / Processingi

Proteomic databases

PRIDEiA8K727.

PTM databases

PhosphoSiteiA8K727.

Expressioni

Gene expression databases

BgeeiA8K727.
ExpressionAtlasiA8K727. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA8K727.
SMRiA8K727. Positions 1-113, 199-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000037398.
HOVERGENiHBG053612.
OMAiEPQHPKE.
PhylomeDBiA8K727.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
MGAGAVGALQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
MKDWVEALNQ ASKITVPKGG GLPMTTEVLK SLAAPPALEK KPQVAYKTEI
160 170 180 190 200
IGGVVVHTPI SQNGGDGQEG SEPGSHTILR RSQSYIPTSG CRASTGPPLI
210 220 230 240 250
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIFLKDVLKT
260 270 280 290 300
HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
310 320 330 340 350
KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV
360 370 380 390 400
ASSWQPWTPV PQAGEKLLPP GDTSEDSLFT PRPGEGSAPG VLPSSRIRHR
410 420
SEPQHPKEKP FMFNLDDENI RTSDV
Length:425
Mass (Da):47,245
Last modified:December 4, 2007 - v1
Checksum:i2A21BE9CE9FD4818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
KF495718 Genomic DNA. No translation available.
AK291842 mRNA. Translation: BAF84531.1.
RefSeqiNP_067636.1. NM_021623.1.
UniGeneiHs.369123.

Genome annotation databases

EnsembliENST00000617275; ENSP00000482228; ENSG00000169499.
GeneIDi59339.
KEGGihsa:59339.
UCSCiuc003xmi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
KF495718 Genomic DNA. No translation available.
AK291842 mRNA. Translation: BAF84531.1.
RefSeqiNP_067636.1. NM_021623.1.
UniGeneiHs.369123.

3D structure databases

ProteinModelPortaliA8K727.
SMRiA8K727. Positions 1-113, 199-299.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA8K727.

Proteomic databases

PRIDEiA8K727.

Protocols and materials databases

DNASUi59339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617275; ENSP00000482228; ENSG00000169499.
GeneIDi59339.
KEGGihsa:59339.
UCSCiuc003xmi.4. human.

Organism-specific databases

CTDi59339.
HGNCiHGNC:14336. PLEKHA2.
PharmGKBiPA33402.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00440000037398.
HOVERGENiHBG053612.
OMAiEPQHPKE.
PhylomeDBiA8K727.

Miscellaneous databases

GenomeRNAii59339.
NextBioi65216.

Gene expression databases

BgeeiA8K727.
ExpressionAtlasiA8K727. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA8K727_HUMAN
AccessioniPrimary (citable) accession number: A8K727
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 29, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.