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A8K6K3

- A8K6K3_HUMAN

UniProt

A8K6K3 - A8K6K3_HUMAN

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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_f

Gene

MAP3K7IP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. kinase activator activity Source: Ensembl
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. activation of MAPKKK activity Source: Ensembl
  2. heart morphogenesis Source: Ensembl
  3. in utero embryonic development Source: Ensembl
  4. lung development Source: Ensembl
  5. positive regulation of MAP kinase activity Source: Ensembl
  6. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_fImported
Submitted name:
cDNA FLJ78598, highly similar to Homo sapiens mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (MAP3K7IP1), transcript variant alpha, mRNAImported
Submitted name:
cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNAImported
Gene namesi
Name:MAP3K7IP1Imported
ORF Names:hCG_41717Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
  3. protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30604.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000216160.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG007302.
KOiK04403.
OMAiSHPPEDN.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequencei

Sequence statusi: Complete.

A8K6K3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST
410 420 430 440 450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT
460 470 480 490 500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV

VTAP
Length:504
Mass (Da):54,644
Last modified:December 4, 2007 - v1
Checksum:iA45743288718983A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291668 mRNA. Translation: BAF84357.1.
AK312456 mRNA. Translation: BAG35363.1.
CH471095 Genomic DNA. Translation: EAW60330.1.
RefSeqiNP_006107.1. NM_006116.2.
UniGeneiHs.507681.
Hs.729080.

Genome annotation databases

GeneIDi10454.
KEGGihsa:10454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291668 mRNA. Translation: BAF84357.1 .
AK312456 mRNA. Translation: BAG35363.1 .
CH471095 Genomic DNA. Translation: EAW60330.1 .
RefSeqi NP_006107.1. NM_006116.2.
UniGenei Hs.507681.
Hs.729080.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000216160.

Protocols and materials databases

DNASUi 10454.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10454.
KEGGi hsa:10454.

Organism-specific databases

CTDi 10454.
PharmGKBi PA30604.

Phylogenomic databases

HOVERGENi HBG007302.
KOi K04403.
OMAi SHPPEDN.

Miscellaneous databases

GenomeRNAii 10454.
NextBioi 39627.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  4. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Caudate nucleusImported.

Entry informationi

Entry nameiA8K6K3_HUMAN
AccessioniPrimary (citable) accession number: A8K6K3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.