UniProtKB - A8K6G4 (A8K6G4_HUMAN)
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Protein
Submitted name:
cDNA FLJ77564
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 347 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 348 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 351 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 357 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
Keywordsi
Ligand | Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ77564Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5002724661 | 29 – 735 | Sequence analysisAdd BLAST | 707 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 479 ↔ 499 | PROSITE-ProRule annotation | ||
Disulfide bondi | 657 ↔ 667 | PROSITE-ProRule annotation | ||
Disulfide bondi | 675 ↔ 684 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationSAAS annotationProteomic databases
PeptideAtlasi | A8K6G4. |
PRIDEi | A8K6G4. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 413 | Peptidase M12BInterPro annotationAdd BLAST | 203 | |
Domaini | 421 – 507 | DisintegrinInterPro annotationAdd BLAST | 87 | |
Domaini | 653 – 685 | EGF-likeInterPro annotationAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 698 – 718 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotationPhylogenomic databases
eggNOGi | KOG3607. Eukaryota. ENOG410XX2M. LUCA. |
HOGENOMi | HOG000230883. |
HOVERGENi | HBG006978. |
Family and domain databases
CDDi | cd04269. ZnMc_adamalysin_II_like. 1 hit. |
Gene3Di | 3.40.390.10. 1 hit. 4.10.70.10. 1 hit. |
InterProi | View protein in InterPro IPR006586. ADAM_Cys-rich. IPR001762. Disintegrin_dom. IPR036436. Disintegrin_dom_sf. IPR000742. EGF-like_dom. IPR024079. MetalloPept_cat_dom_sf. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. IPR034027. Reprolysin_adamalysin. |
Pfami | View protein in Pfam PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. |
PRINTSi | PR00289. DISINTEGRIN. |
SMARTi | View protein in SMART SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. |
SUPFAMi | SSF57552. SSF57552. 1 hit. |
PROSITEi | View protein in PROSITE PS50215. ADAM_MEPRO. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS50026. EGF_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
A8K6G4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVRSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270 280 290 300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA
310 320 330 340 350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG
360 370 380 390 400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS
410 420 430 440 450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA
460 470 480 490 500
TTCTLKPDAV CAHGLCCEDR QLKPAGTACR DSSNSCDLPE FCTGASPHCP
510 520 530 540 550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN
560 570 580 590 600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET
610 620 630 640 650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS
660 670 680 690 700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ
710 720 730
AEARQEAAES NRERGQGQEP VGSQEHASTA SLTLI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291629 mRNA. Translation: BAF84318.1. |
RefSeqi | NP_001275904.1. NM_001288975.1. NP_067673.2. NM_021641.4. |
UniGenei | Hs.594351. Hs.741333. |
Genome annotation databases
GeneIDi | 8038. |
Similar proteinsi
Entry informationi
Entry namei | A8K6G4_HUMAN | |
Accessioni | A8K6G4Primary (citable) accession number: A8K6G4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | January 31, 2018 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation