cDNA FLJ77564

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	347	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	348	PROSITE-ProRule annotation	1
Metal bindingⁱ	351	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	357	Zinc; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
metalloendopeptidase activity Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Ligand

Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cDNA FLJ77564Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA24507.

PharmGKBⁱ

PA24507.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_5002724661	29 – 735	Sequence analysisAdd BLAST		707

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	479 ↔ 499	PROSITE-ProRule annotation
Disulfide bondⁱ	657 ↔ 667	PROSITE-ProRule annotation
Disulfide bondⁱ	675 ↔ 684	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbⁱ	A8K6G4.
PeptideAtlas More...PeptideAtlasⁱ	A8K6G4.
PRIDEⁱ	A8K6G4.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	A8K6G4. HS.

Genevisibleⁱ

A8K6G4. HS.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A8K6G4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	211 – 413	Peptidase M12BInterPro annotationAdd BLAST	203
Domainⁱ	421 – 507	DisintegrinInterPro annotationAdd BLAST	87
Domainⁱ	653 – 685	EGF-likeInterPro annotationAdd BLAST	33

Keywords - Domainⁱ

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
HOGENOMⁱ	HOG000230883.
HOVERGENⁱ	HBG006978.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006586. ADAM_Cys-rich. IPR001762. Disintegrin_dom. IPR000742. EGF-like_dom. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. IPR034027. Reprolysin_adamalysin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit.
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	View protein in SMART SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit.
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50215. ADAM_MEPRO. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS50026. EGF_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A8K6G4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVRSG 
        60         70         80         90        100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL 
       110        120        130        140        150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV 
       160        170        180        190        200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR 
       210        220        230        240        250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR 
       260        270        280        290        300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA 
       310        320        330        340        350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG 
       360        370        380        390        400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS 
       410        420        430        440        450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA 
       460        470        480        490        500
TTCTLKPDAV CAHGLCCEDR QLKPAGTACR DSSNSCDLPE FCTGASPHCP 
       510        520        530        540        550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN 
       560        570        580        590        600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET 
       610        620        630        640        650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS 
       660        670        680        690        700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ 
       710        720        730 
AEARQEAAES NRERGQGQEP VGSQEHASTA SLTLI

Length:735

Mass (Da):80,230

Last modified:December 4, 2007 - v1

Checksum:ⁱCD0F7616961ED240

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK291629 mRNA. Translation: BAF84318.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001275904.1. NM_001288975.1. NP_067673.2. NM_021641.4.
UniGeneⁱ	Hs.594351. Hs.741333.

Genome annotation databases

GeneIDⁱ	8038.

GeneIDⁱ

8038.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A8K6G4	O43184-2 UPI0008F50C86 O43184-4 UPI000533277D UPI0007DBC3FC UPI0008F48C63 K7CSG7 K7DND5 O43184-3 UPI0008F4DEFE	Gorilla gorilla gorilla (Western lowland gorilla) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Pan troglodytes (Chimpanzee) Homo sapiens (Human)	738	UniRef90_O43184-2	Cluster: Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 12	11

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A8K6G4	O43184-2 UPI0008F50C86 O43184-4 UPI0008F48C63 UPI0007DBC3FC UPI000533277D K7CSG7 UPI0008F4DEFE O43184-3 K7DND5 +26	Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Homo sapiens (Human) Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Macaca mulatta (Rhesus macaque) Meleagris gallopavo (Common turkey) Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor) Pelecanus crispus (Dalmatian pelican) And more	738	UniRef50_O43184-2	Cluster: Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 12	37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK291629 mRNA. Translation: BAF84318.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001275904.1. NM_001288975.1. NP_067673.2. NM_021641.4.
UniGeneⁱ	Hs.594351. Hs.741333.

3D structure databases

ProteinModelPortalⁱ	A8K6G4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	A8K6G4.
PeptideAtlas More...PeptideAtlasⁱ	A8K6G4.
PRIDEⁱ	A8K6G4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	8038.

GeneIDⁱ

8038.

Organism-specific databases

CTDⁱ	8038.
PharmGKBⁱ	PA24507.

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
HOGENOMⁱ	HOG000230883.
HOVERGENⁱ	HBG006978.

Miscellaneous databases

GenomeRNAiⁱ	8038.

GenomeRNAiⁱ

8038.

Gene expression databases

Genevisibleⁱ	A8K6G4. HS.

Genevisibleⁱ

A8K6G4. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006586. ADAM_Cys-rich. IPR001762. Disintegrin_dom. IPR000742. EGF-like_dom. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. IPR034027. Reprolysin_adamalysin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit.
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	View protein in SMART SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit.
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50215. ADAM_MEPRO. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS50026. EGF_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8K6G4_HUMAN
Accessionⁱ	A8K6G4Primary (citable) accession number: A8K6G4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	August 30, 2017
	This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A8K6G4 (A8K6G4_HUMAN)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ