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Protein

Interleukin-7

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7UniRule annotation
Short name:
IL-7UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500272545826 – 177Interleukin-7Sequence analysisAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 166UniRule annotation
Disulfide bondi59 ↔ 154UniRule annotation
Disulfide bondi72 ↔ 117UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiA8K673.
PeptideAtlasiA8K673.
PRIDEiA8K673.

Expressioni

Gene expression databases

GenevisibleiA8K673. HS.

Interactioni

Protein-protein interaction databases

IntActiA8K673. 1 interactor.
STRINGi9606.ENSP00000263851.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
HOVERGENiHBG004609.
KOiK05431.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDSKQYESV LMVSIDQLLD
60 70 80 90 100
SMKEIGSNCL NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF
110 120 130 140 150
DLHLLKVSEG TTILLNCTGQ VKGRKPAALG EAQPTKSLEE NKSLKEQKKL
160 170
NDLCFLKRLL QEIKTCWNKI LMGTKEH
Length:177
Mass (Da):20,217
Last modified:December 4, 2007 - v1
Checksum:i444BFEFF9173BBB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291538 mRNA. Translation: BAF84227.1.
RefSeqiNP_000871.1. NM_000880.3.
NP_001186815.1. NM_001199886.1.
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGeneiHs.591873.

Genome annotation databases

GeneIDi3574.
KEGGihsa:3574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291538 mRNA. Translation: BAF84227.1.
RefSeqiNP_000871.1. NM_000880.3.
NP_001186815.1. NM_001199886.1.
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGeneiHs.591873.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA8K673. 1 interactor.
STRINGi9606.ENSP00000263851.

Proteomic databases

PaxDbiA8K673.
PeptideAtlasiA8K673.
PRIDEiA8K673.

Protocols and materials databases

DNASUi3574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3574.
KEGGihsa:3574.

Organism-specific databases

CTDi3574.

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
HOVERGENiHBG004609.
KOiK05431.

Miscellaneous databases

GenomeRNAii3574.

Gene expression databases

GenevisibleiA8K673. HS.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K673_HUMAN
AccessioniPrimary (citable) accession number: A8K673
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 5, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.