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Protein

Interleukin-7

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7UniRule annotation
Short name:
IL-7UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500272545826 – 177Interleukin-7Sequence analysisAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 166UniRule annotation
Disulfide bondi59 ↔ 154UniRule annotation
Disulfide bondi72 ↔ 117UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PeptideAtlasiA8K673
PRIDEiA8K673

Expressioni

Gene expression databases

GenevisibleiA8K673 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA8K673, 1 interactor

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW6Q Eukaryota
ENOG41114MI LUCA
HOVERGENiHBG004609
KOiK05431

Family and domain databases

Gene3Di1.20.1250.50, 1 hit
InterProiView protein in InterPro
IPR001181 IL-7
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR038325 IL7_sf
PANTHERiPTHR45542 PTHR45542, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PIRSFiPIRSF001942 IL-7, 1 hit
PRINTSiPR00435 INTERLEUKIN7
SMARTiView protein in SMART
SM00127 IL7, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequencei

Sequence statusi: Complete.

A8K673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDSKQYESV LMVSIDQLLD
60 70 80 90 100
SMKEIGSNCL NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF
110 120 130 140 150
DLHLLKVSEG TTILLNCTGQ VKGRKPAALG EAQPTKSLEE NKSLKEQKKL
160 170
NDLCFLKRLL QEIKTCWNKI LMGTKEH
Length:177
Mass (Da):20,217
Last modified:December 4, 2007 - v1
Checksum:i444BFEFF9173BBB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291538 mRNA Translation: BAF84227.1
RefSeqiNP_000871.1, NM_000880.3
NP_001186815.1, NM_001199886.1
NP_001186816.1, NM_001199887.1
NP_001186817.1, NM_001199888.1
UniGeneiHs.591873

Genome annotation databases

GeneIDi3574
KEGGihsa:3574

Similar proteinsi

Entry informationi

Entry nameiA8K673_HUMAN
AccessioniPrimary (citable) accession number: A8K673
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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