ID CC120_HUMAN Reviewed; 630 AA. AC Q96HB5; A8K5Q5; B4DF24; B4DFC1; B4DTU2; F5GZU4; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 159. DE RecName: Full=Coiled-coil domain-containing protein 120; GN Name=CCDC120; ORFNames=JM11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Rolfs A., Kelley F., McCarron S., Jepson D., Shen B., Shi Z., Hu Y., RA Taycher E., Zuo D., Ebert L., Hoerlein A., Ernst U., Korn B., LaBaer J.; RT "Cloning of human full-length CDS FLEXGene in Gateway(TM) recombinational RT vector system."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5). RC TISSUE=Cerebellum, Fetal brain, and Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Choriocarcinoma; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryonic kidney; RX PubMed=17525332; DOI=10.1126/science.1140321; RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., RA Gygi S.P., Elledge S.J.; RT "ATM and ATR substrate analysis reveals extensive protein networks RT responsive to DNA damage."; RL Science 316:1160-1166(2007). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] RP FUNCTION, INTERACTION WITH CYTH2, SUBCELLULAR LOCATION, AND UBIQUITINATION. RX PubMed=25326380; DOI=10.1074/jbc.m114.575787; RA Torii T., Miyamoto Y., Tago K., Sango K., Nakamura K., Sanbe A., Tanoue A., RA Yamauchi J.; RT "Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and RT is transported along neurites to mediate neurite growth."; RL J. Biol. Chem. 289:33887-33903(2014). RN [12] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH NIN AND CEP170. RX PubMed=28422092; DOI=10.1038/ncomms15057; RA Huang N., Xia Y., Zhang D., Wang S., Bao Y., He R., Teng J., Chen J.; RT "Hierarchical assembly of centriole subdistal appendages via centrosome RT binding proteins CCDC120 and CCDC68."; RL Nat. Commun. 8:15057-15057(2017). CC -!- FUNCTION: Centriolar protein required for centriole subdistal appendage CC assembly and microtubule anchoring in interphase cells CC (PubMed:28422092). Together with CCDC68, cooperate with subdistal CC appendage components ODF2, NIN and CEP170 for hierarchical subdistal CC appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to CC centrosomes (PubMed:28422092). Also required for neurite growth. CC Localizes CYTH2 to vesicles to allow its transport along neurites, and CC subsequent ARF6 activation and neurite growth. CC {ECO:0000269|PubMed:25326380}. CC -!- SUBUNIT: Interacts with NIN and CEP170; leading to recruit them to CC centrosomes (PubMed:28422092). Directly interacts with CYTH2; this CC interaction stabilizes CCDC120, possibly by preventing ubiquitination. CC {ECO:0000269|PubMed:25326380, ECO:0000269|PubMed:28422092}. CC -!- INTERACTION: CC Q96HB5; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-744556, EBI-8643161; CC Q96HB5; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-744556, EBI-357530; CC Q96HB5; Q03989: ARID5A; NbExp=3; IntAct=EBI-744556, EBI-948603; CC Q96HB5; Q9Y6H3: ATP23; NbExp=3; IntAct=EBI-744556, EBI-12811889; CC Q96HB5; O75934: BCAS2; NbExp=3; IntAct=EBI-744556, EBI-1050106; CC Q96HB5; Q9H2G9: BLZF1; NbExp=5; IntAct=EBI-744556, EBI-2548012; CC Q96HB5; A2RRN7: CADPS; NbExp=3; IntAct=EBI-744556, EBI-10179719; CC Q96HB5; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-744556, EBI-739580; CC Q96HB5; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-744556, EBI-11530605; CC Q96HB5; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-744556, EBI-10171570; CC Q96HB5; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-744556, EBI-10961312; CC Q96HB5; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-744556, EBI-10961624; CC Q96HB5; Q01850: CDR2; NbExp=3; IntAct=EBI-744556, EBI-1181367; CC Q96HB5; Q5SW79: CEP170; NbExp=12; IntAct=EBI-744556, EBI-1104799; CC Q96HB5; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-744556, EBI-747776; CC Q96HB5; P61024: CKS1B; NbExp=3; IntAct=EBI-744556, EBI-456371; CC Q96HB5; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-744556, EBI-12819063; CC Q96HB5; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-744556, EBI-3866319; CC Q96HB5; P56545-3: CTBP2; NbExp=3; IntAct=EBI-744556, EBI-10171902; CC Q96HB5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-744556, EBI-3867333; CC Q96HB5; Q15438: CYTH1; NbExp=9; IntAct=EBI-744556, EBI-997830; CC Q96HB5; Q99418: CYTH2; NbExp=4; IntAct=EBI-744556, EBI-448974; CC Q96HB5; O43739-2: CYTH3; NbExp=4; IntAct=EBI-744556, EBI-11974015; CC Q96HB5; Q9UIA0: CYTH4; NbExp=8; IntAct=EBI-744556, EBI-11521003; CC Q96HB5; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-744556, EBI-2349927; CC Q96HB5; O00303: EIF3F; NbExp=3; IntAct=EBI-744556, EBI-711990; CC Q96HB5; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-744556, EBI-11958845; CC Q96HB5; P22607: FGFR3; NbExp=3; IntAct=EBI-744556, EBI-348399; CC Q96HB5; P01100: FOS; NbExp=3; IntAct=EBI-744556, EBI-852851; CC Q96HB5; P15407: FOSL1; NbExp=3; IntAct=EBI-744556, EBI-744510; CC Q96HB5; A1L4K1: FSD2; NbExp=3; IntAct=EBI-744556, EBI-5661036; CC Q96HB5; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-744556, EBI-7960826; CC Q96HB5; P14136: GFAP; NbExp=3; IntAct=EBI-744556, EBI-744302; CC Q96HB5; Q08379: GOLGA2; NbExp=3; IntAct=EBI-744556, EBI-618309; CC Q96HB5; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-744556, EBI-5916454; CC Q96HB5; Q6PI77: GPRASP3; NbExp=3; IntAct=EBI-744556, EBI-11519926; CC Q96HB5; P31943: HNRNPH1; NbExp=3; IntAct=EBI-744556, EBI-351590; CC Q96HB5; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-744556, EBI-748420; CC Q96HB5; P49639: HOXA1; NbExp=5; IntAct=EBI-744556, EBI-740785; CC Q96HB5; P01112: HRAS; NbExp=3; IntAct=EBI-744556, EBI-350145; CC Q96HB5; O75031: HSF2BP; NbExp=3; IntAct=EBI-744556, EBI-7116203; CC Q96HB5; P42858: HTT; NbExp=3; IntAct=EBI-744556, EBI-466029; CC Q96HB5; Q13099: IFT88; NbExp=3; IntAct=EBI-744556, EBI-347427; CC Q96HB5; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-744556, EBI-8638439; CC Q96HB5; Q5TA45: INTS11; NbExp=3; IntAct=EBI-744556, EBI-748258; CC Q96HB5; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-744556, EBI-749265; CC Q96HB5; Q15323: KRT31; NbExp=3; IntAct=EBI-744556, EBI-948001; CC Q96HB5; O76011: KRT34; NbExp=3; IntAct=EBI-744556, EBI-1047093; CC Q96HB5; Q92764: KRT35; NbExp=3; IntAct=EBI-744556, EBI-1058674; CC Q96HB5; O76015: KRT38; NbExp=3; IntAct=EBI-744556, EBI-1047263; CC Q96HB5; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-744556, EBI-10241252; CC Q96HB5; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-744556, EBI-12811111; CC Q96HB5; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-744556, EBI-12111050; CC Q96HB5; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-744556, EBI-11962084; CC Q96HB5; Q03252: LMNB2; NbExp=3; IntAct=EBI-744556, EBI-2830427; CC Q96HB5; P61968: LMO4; NbExp=3; IntAct=EBI-744556, EBI-2798728; CC Q96HB5; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-744556, EBI-1216080; CC Q96HB5; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-744556, EBI-716006; CC Q96HB5; Q9P086: MED11; NbExp=3; IntAct=EBI-744556, EBI-394704; CC Q96HB5; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-744556, EBI-8487781; CC Q96HB5; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-744556, EBI-10172526; CC Q96HB5; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-744556, EBI-2801965; CC Q96HB5; Q8TD10: MIPOL1; NbExp=6; IntAct=EBI-744556, EBI-2548751; CC Q96HB5; Q13064: MKRN3; NbExp=3; IntAct=EBI-744556, EBI-2340269; CC Q96HB5; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-744556, EBI-720441; CC Q96HB5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-744556, EBI-11522433; CC Q96HB5; P15173: MYOG; NbExp=3; IntAct=EBI-744556, EBI-3906629; CC Q96HB5; O43639: NCK2; NbExp=3; IntAct=EBI-744556, EBI-713635; CC Q96HB5; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-744556, EBI-11750983; CC Q96HB5; Q8N4C6: NIN; NbExp=11; IntAct=EBI-744556, EBI-1164022; CC Q96HB5; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-744556, EBI-17490746; CC Q96HB5; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-744556, EBI-398874; CC Q96HB5; Q5BJF6: ODF2; NbExp=5; IntAct=EBI-744556, EBI-8744243; CC Q96HB5; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-744556, EBI-11022007; CC Q96HB5; P16284: PECAM1; NbExp=3; IntAct=EBI-744556, EBI-716404; CC Q96HB5; Q99959-2: PKP2; NbExp=3; IntAct=EBI-744556, EBI-10987518; CC Q96HB5; O15496: PLA2G10; NbExp=3; IntAct=EBI-744556, EBI-726466; CC Q96HB5; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-744556, EBI-2876622; CC Q96HB5; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-744556, EBI-949255; CC Q96HB5; Q16633: POU2AF1; NbExp=3; IntAct=EBI-744556, EBI-943588; CC Q96HB5; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-744556, EBI-11320284; CC Q96HB5; P41219: PRPH; NbExp=3; IntAct=EBI-744556, EBI-752074; CC Q96HB5; P20339: RAB5A; NbExp=3; IntAct=EBI-744556, EBI-399437; CC Q96HB5; Q15276: RABEP1; NbExp=3; IntAct=EBI-744556, EBI-447043; CC Q96HB5; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-744556, EBI-740343; CC Q96HB5; Q9P2R6: RERE; NbExp=3; IntAct=EBI-744556, EBI-948076; CC Q96HB5; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-744556, EBI-726876; CC Q96HB5; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-744556, EBI-6257312; CC Q96HB5; O60504: SORBS3; NbExp=3; IntAct=EBI-744556, EBI-741237; CC Q96HB5; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-744556, EBI-11959123; CC Q96HB5; O75558: STX11; NbExp=3; IntAct=EBI-744556, EBI-714135; CC Q96HB5; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-744556, EBI-1105213; CC Q96HB5; Q08117-2: TLE5; NbExp=6; IntAct=EBI-744556, EBI-11741437; CC Q96HB5; Q12888: TP53BP1; NbExp=3; IntAct=EBI-744556, EBI-396540; CC Q96HB5; Q13077: TRAF1; NbExp=3; IntAct=EBI-744556, EBI-359224; CC Q96HB5; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-744556, EBI-5235829; CC Q96HB5; Q15654: TRIP6; NbExp=3; IntAct=EBI-744556, EBI-742327; CC Q96HB5; Q86WV8: TSC1; NbExp=3; IntAct=EBI-744556, EBI-12806590; CC Q96HB5; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-744556, EBI-10241197; CC Q96HB5; P08670: VIM; NbExp=3; IntAct=EBI-744556, EBI-353844; CC Q96HB5; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-744556, EBI-11962760; CC Q96HB5; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-744556, EBI-7850213; CC Q96HB5; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-744556, EBI-740727; CC Q96HB5; Q5T619: ZNF648; NbExp=3; IntAct=EBI-744556, EBI-11985915; CC Q96HB5; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-744556, EBI-527853; CC Q96HB5; Q9Y649; NbExp=3; IntAct=EBI-744556, EBI-25900580; CC Q96HB5-4; Q68D86: CCDC102B; NbExp=4; IntAct=EBI-10185348, EBI-10171570; CC Q96HB5-4; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-10185348, EBI-2808286; CC Q96HB5-4; Q96L14: CEP170P1; NbExp=4; IntAct=EBI-10185348, EBI-743488; CC Q96HB5-4; Q99418: CYTH2; NbExp=4; IntAct=EBI-10185348, EBI-448974; CC Q96HB5-4; O43739: CYTH3; NbExp=3; IntAct=EBI-10185348, EBI-741648; CC Q96HB5-4; Q5JST6: EFHC2; NbExp=4; IntAct=EBI-10185348, EBI-2349927; CC Q96HB5-4; Q15323: KRT31; NbExp=4; IntAct=EBI-10185348, EBI-948001; CC Q96HB5-4; Q6A162: KRT40; NbExp=4; IntAct=EBI-10185348, EBI-10171697; CC Q96HB5-4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10185348, EBI-10172526; CC Q96HB5-4; Q13077: TRAF1; NbExp=4; IntAct=EBI-10185348, EBI-359224; CC Q96HB5-4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10185348, EBI-739895; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome, centriole {ECO:0000269|PubMed:28422092}. Cytoplasm CC {ECO:0000269|PubMed:25326380}. Cell projection, neuron projection CC {ECO:0000269|PubMed:25326380}. Cell projection, growth cone CC {ECO:0000269|PubMed:25326380}. Endosome {ECO:0000269|PubMed:25326380}. CC Note=Localizes to the subdistal appendages of mother centrioles and CC proximal ends of both centrioles in interphase cells (PubMed:28422092). CC Recruited to subdistal appendages by ODF2 (PubMed:28422092). In CC differentiating neuroblastoma cells, colocalizes with CYTH2 in both CC neurite shaft and growth cone areas (PubMed:25326380). Partially CC colocalizes with endosomes along neurites in differentiating CC neuroblastoma cells (PubMed:25326380). {ECO:0000269|PubMed:25326380, CC ECO:0000269|PubMed:28422092}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q96HB5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96HB5-2; Sequence=VSP_042859; CC Name=3; CC IsoId=Q96HB5-3; Sequence=VSP_047104; CC Name=4; CC IsoId=Q96HB5-4; Sequence=VSP_054527, VSP_047104; CC Name=5; CC IsoId=Q96HB5-5; Sequence=VSP_042859, VSP_047104; CC -!- PTM: Ubiquitinated; interaction with CYTH2 may prevent ubiquitination. CC {ECO:0000269|PubMed:25326380}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ896186; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK293898; BAG57285.1; -; mRNA. DR EMBL; AK294024; BAG57382.1; -; mRNA. DR EMBL; AK291370; BAF84059.1; -; mRNA. DR EMBL; AK300366; BAG62104.1; -; mRNA. DR EMBL; AK315837; BAF98728.1; -; mRNA. DR EMBL; AF196779; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471224; EAW50708.1; -; Genomic_DNA. DR EMBL; BC008769; AAH08769.1; -; mRNA. DR CCDS; CCDS14316.1; -. [Q96HB5-1] DR CCDS; CCDS55413.1; -. [Q96HB5-2] DR CCDS; CCDS55414.2; -. [Q96HB5-4] DR RefSeq; NP_001156793.2; NM_001163321.2. [Q96HB5-4] DR RefSeq; NP_001156794.1; NM_001163322.2. [Q96HB5-5] DR RefSeq; NP_001156795.1; NM_001163323.2. [Q96HB5-2] DR RefSeq; NP_001258764.1; NM_001271835.1. [Q96HB5-1] DR RefSeq; NP_001258765.1; NM_001271836.1. [Q96HB5-1] DR RefSeq; NP_296375.1; NM_033626.3. [Q96HB5-1] DR AlphaFoldDB; Q96HB5; -. DR SMR; Q96HB5; -. DR BioGRID; 124658; 174. DR IntAct; Q96HB5; 162. DR MINT; Q96HB5; -. DR STRING; 9606.ENSP00000474071; -. DR iPTMnet; Q96HB5; -. DR PhosphoSitePlus; Q96HB5; -. DR BioMuta; CCDC120; -. DR DMDM; 74731908; -. DR EPD; Q96HB5; -. DR jPOST; Q96HB5; -. DR MassIVE; Q96HB5; -. DR MaxQB; Q96HB5; -. DR PaxDb; 9606-ENSP00000474071; -. DR PeptideAtlas; Q96HB5; -. DR ProteomicsDB; 25131; -. DR ProteomicsDB; 76728; -. [Q96HB5-1] DR ProteomicsDB; 76729; -. [Q96HB5-2] DR Antibodypedia; 347; 136 antibodies from 21 providers. DR DNASU; 90060; -. DR Ensembl; ENST00000496529.6; ENSP00000474761.1; ENSG00000147144.13. [Q96HB5-1] DR Ensembl; ENST00000536628.3; ENSP00000443351.1; ENSG00000147144.13. [Q96HB5-2] DR Ensembl; ENST00000597275.5; ENSP00000470294.1; ENSG00000147144.13. [Q96HB5-1] DR Ensembl; ENST00000603906.2; ENSP00000474713.2; ENSG00000147144.13. [Q96HB5-5] DR Ensembl; ENST00000603986.6; ENSP00000474071.1; ENSG00000147144.13. [Q96HB5-4] DR Ensembl; ENST00000606812.5; ENSP00000475676.1; ENSG00000147144.13. [Q96HB5-1] DR Ensembl; ENST00000710653.1; ENSP00000518402.1; ENSG00000292279.1. [Q96HB5-1] DR Ensembl; ENST00000710666.1; ENSP00000518407.1; ENSG00000292279.1. [Q96HB5-1] DR Ensembl; ENST00000710667.1; ENSP00000518408.1; ENSG00000292279.1. [Q96HB5-1] DR Ensembl; ENST00000710668.1; ENSP00000518409.1; ENSG00000292279.1. [Q96HB5-4] DR Ensembl; ENST00000710669.1; ENSP00000518410.1; ENSG00000292279.1. [Q96HB5-2] DR Ensembl; ENST00000710670.1; ENSP00000518411.1; ENSG00000292279.1. [Q96HB5-5] DR GeneID; 90060; -. DR KEGG; hsa:90060; -. DR MANE-Select; ENST00000603986.6; ENSP00000474071.1; NM_001163321.4; NP_001156793.2. [Q96HB5-4] DR UCSC; uc064zdh.1; human. [Q96HB5-1] DR AGR; HGNC:28910; -. DR CTD; 90060; -. DR GeneCards; CCDC120; -. DR HGNC; HGNC:28910; CCDC120. DR HPA; ENSG00000147144; Tissue enhanced (esophagus, skin). DR MIM; 300947; gene. DR neXtProt; NX_Q96HB5; -. DR OpenTargets; ENSG00000147144; -. DR PharmGKB; PA145149329; -. DR VEuPathDB; HostDB:ENSG00000147144; -. DR eggNOG; KOG3529; Eukaryota. DR GeneTree; ENSGT00940000154102; -. DR HOGENOM; CLU_029533_0_0_1; -. DR InParanoid; Q96HB5; -. DR OMA; RSKDPHA; -. DR OrthoDB; 5357365at2759; -. DR PhylomeDB; Q96HB5; -. DR TreeFam; TF328984; -. DR PathwayCommons; Q96HB5; -. DR SignaLink; Q96HB5; -. DR BioGRID-ORCS; 90060; 5 hits in 787 CRISPR screens. DR ChiTaRS; CCDC120; human. DR GenomeRNAi; 90060; -. DR Pharos; Q96HB5; Tbio. DR PRO; PR:Q96HB5; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q96HB5; Protein. DR Bgee; ENSG00000147144; Expressed in lower esophagus mucosa and 99 other cell types or tissues. DR ExpressionAtlas; Q96HB5; baseline and differential. DR GO; GO:0120103; C:centriolar subdistal appendage; IDA:GO_Central. DR GO; GO:0005814; C:centriole; IDA:GO_Central. DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell. DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell. DR GO; GO:0034454; P:microtubule anchoring at centrosome; IMP:GO_Central. DR GO; GO:0008104; P:protein localization; IMP:GO_Central. DR InterPro; IPR043447; CCDC120/INAVA. DR InterPro; IPR021774; CUPID. DR PANTHER; PTHR16093:SF5; COILED-COIL DOMAIN-CONTAINING PROTEIN 120; 1. DR PANTHER; PTHR16093; COILED-COIL DOMAIN-CONTAINING PROTEIN 120 FAMILY MEMBER; 1. DR Pfam; PF11819; CUPID; 1. DR Genevisible; Q96HB5; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell projection; Coiled coil; Cytoplasm; KW Cytoskeleton; Developmental protein; Endosome; Methylation; Phosphoprotein; KW Reference proteome; Ubl conjugation. FT CHAIN 1..630 FT /note="Coiled-coil domain-containing protein 120" FT /id="PRO_0000254141" FT REGION 31..70 FT /note="Involved in CYTH2-binding" FT /evidence="ECO:0000269|PubMed:25326380" FT REGION 212..435 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 457..534 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 109..173 FT /evidence="ECO:0000255" FT COMPBIAS 278..303 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 408..422 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 358 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 360 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:23186163" FT MOD_RES 435 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:A2AEV7" FT VAR_SEQ 1 FT /note="M -> MRREPRYQGQVGPDIHTDSERTLSSHQPRPLDSTKM (in FT isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_054527" FT VAR_SEQ 5..16 FT /note="Missing (in isoform 2 and isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_042859" FT VAR_SEQ 626..630 FT /note="GGCFY -> YADFLYPPELSARLSDLTLEGEQSSSSDTQTPGTLV (in FT isoform 3, isoform 4 and isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047104" SQ SEQUENCE 630 AA; 67567 MW; E652C8AFD738BF6E CRC64; MEVKGQLISS PTFNAPAALF GEAAPQVKSE RLRGLLDRQR TLQEALSLKL QELRKVCLQE AELTGQLPPE CPLEPGERPQ LVRRRPPTAR AYPPPHPNQA HHSLCPAEEL ALEALEREVS VQQQIAAAAR RLALAPDLST EQRRRRRQVQ ADALRRLHEL EEQLRDVRAR LGLPVLPLPQ PLPLSTGSVI TTQGVCLGMR LAQLSQEDVV LHSESSSLSE SGASHDNEEP HGCFSLAERP SPPKAWDQLR AVSGGSPERR TPWKPPPSDL YGDLKSRRNS VASPTSPTRS LPRSASSFEG RSVPATPVLT RGAGPQLCKP EGLHSRQWSG SQDSQMGFPR ADPASDRASL FVARTRRSNS SEALLVDRAA GGGAGSPPAP LAPSASGPPV CKSSEVLYER PQPTPAFSSR TAGPPDPPRA ARPSSAAPAS RGAPRLPPVC GDFLLDYSLD RGLPRSGGGT GWGELPPAAE VPGPLSRRDG LLTMLPGPPP VYAADSNSPL LRTKDPHTRA TRTKPCGLPP EAAEGPEVHP NPLLWMPPPT RIPSAGERSG HKNLALEGLR DWYIRNSGLA AGPQRRPVLP SVGPPHPPFL HARCYEVGQA LYGAPSQAPL PHSRSFTAPP VSGRYGGCFY //