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Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA8K5M4

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32918

PTM / Processingi

Proteomic databases

PeptideAtlasiA8K5M4
PRIDEiA8K5M4

Expressioni

Gene expression databases

GenevisibleiA8K5M4 HS

Structurei

3D structure databases

ProteinModelPortaliA8K5M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 87CRIBInterPro annotationAdd BLAST14
Domaini249 – 500Protein kinaseInterPro annotationAdd BLAST252

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
HOVERGENiHBG108518
KOiK04410

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
cd06655 STKc_PAK2, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR035065 PAK2/3
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR035064 STK_PAK2
PANTHERiPTHR24361:SF250 PTHR24361:SF250, 1 hit
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A8K5M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR
60 70 80 90 100
HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE
110 120 130 140 150
QWARLLQTSD ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF
160 170 180 190 200
PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID
210 220 230 240 250
PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT
260 270 280 290 300
RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE
310 320 330 340 350
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR
360 370 380 390 400
ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR
410 420 430 440 450
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR
460 470 480 490 500
ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL
510 520
KLAKPLSSLT PLIMAAKEAM KSNR
Length:524
Mass (Da):58,044
Last modified:December 4, 2007 - v1
Checksum:i8352E6C271F5EF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291339 mRNA Translation: BAF84028.1
RefSeqiNP_002568.2, NM_002577.4
UniGeneiHs.518530

Genome annotation databases

GeneIDi5062
KEGGihsa:5062

Similar proteinsi

Entry informationi

Entry nameiA8K5M4_HUMAN
AccessioniPrimary (citable) accession number: A8K5M4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health