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Protein
Submitted name:

Epididymis secretory protein Li 103

Gene

HSPA1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processStress responseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Epididymis secretory protein Li 103Imported
Submitted name:
HSPA1AImported
Submitted name:
HSPA1BImported
Submitted name:
Heat shock 70kDa protein 1AImported
Submitted name:
Heat shock 70kDa protein 1BImported
Submitted name:
cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNAImported
Gene namesi
Name:HSPA1BImported
Synonyms:HEL-S-103Imported, HSPA1AImported
ORF Names:hCG_1820593Imported, hCG_43726Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29499.

Expressioni

Gene expression databases

BgeeiENSG00000204388.
ExpressionAtlasiA8K5I0. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA8K5I0. 2 interactors.

Structurei

3D structure databases

SMRiA8K5I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili512 – 535Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
HOVERGENiHBG051845.
KOiK03283.
OMAiVDWLDHN.
OrthoDBiEOG093705LK.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A8K5I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK
110 120 130 140 150
PKVQVSYKGE TKAFYPEEIS SMVLTKMKEI AEAYLGYPVT NAVITVPAYF
160 170 180 190 200
NDSQRQATKD AGVIAGLNVL RIINEPTAAA IAYGLDRTGK GERNVLIFDL
210 220 230 240 250
GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH FVEEFKRKHK
260 270 280 290 300
KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
310 320 330 340 350
RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL
360 370 380 390 400
QDFFNGRDLN KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS
410 420 430 440 450
LGLETAGGVM TALIKRNSTI PTKQTQIFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI DANGILNVTA TDKSTGKANK
510 520 530 540 550
ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN ALESYAFNMK
560 570 580 590 600
SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
610 620 630 640
QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D
Length:641
Mass (Da):70,052
Last modified:December 4, 2007 - v1
Checksum:i78F513118C96DE66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ224292 mRNA. Translation: ACI45984.1.
KY500377 Genomic DNA. Translation: AQY76864.1.
KY500378 Genomic DNA. Translation: AQY76865.1.
KY500379 Genomic DNA. Translation: AQY76866.1.
KY500381 Genomic DNA. Translation: AQY76868.1.
KY500382 Genomic DNA. Translation: AQY76869.1.
KY500383 Genomic DNA. Translation: AQY76870.1.
KY500384 Genomic DNA. Translation: AQY76871.1.
KY500387 Genomic DNA. Translation: AQY76874.1.
KY500388 Genomic DNA. Translation: AQY76875.1.
KY500389 Genomic DNA. Translation: AQY76876.1.
KY500390 Genomic DNA. Translation: AQY76877.1.
KY500392 Genomic DNA. Translation: AQY76879.1.
KY500393 Genomic DNA. Translation: AQY76880.1.
KY500394 Genomic DNA. Translation: AQY76881.1.
KY500395 Genomic DNA. Translation: AQY76882.1.
KY500396 Genomic DNA. Translation: AQY76883.1.
KY500397 Genomic DNA. Translation: AQY76884.1.
AK291295 mRNA. Translation: BAF83984.1.
CH471081 Genomic DNA. Translation: EAX03528.1.
CH471081 Genomic DNA. Translation: EAX03529.1.
RefSeqiNP_005336.3. NM_005345.5.
NP_005337.2. NM_005346.4.
UniGeneiHs.274402.
Hs.702139.
Hs.719966.
Hs.743411.

Genome annotation databases

GeneIDi3303.
3304.
KEGGihsa:3303.
hsa:3304.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8K5I0_HUMAN
AccessioniPrimary (citable) accession number: A8K5I0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 5, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.