A8K557 (A8K557_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ78195, highly similar to Homo sapiens transcription factor AP-2 beta (activating enhancer binding protein 2 beta), mRNA EMBL BAF83861.1
Organism	Homo sapiens (Human) EMBL BAF83861.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	aorta morphogenesis Inferred from electronic annotation. Source: Compara calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular ammonia homeostasis Inferred from electronic annotation. Source: Compara cellular creatinine homeostasis Inferred from electronic annotation. Source: Compara cellular urea homeostasis Inferred from electronic annotation. Source: Compara collecting duct development Inferred from electronic annotation. Source: Compara distal tubule development Inferred from electronic annotation. Source: Compara ductus arteriosus closure Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from electronic annotation. Source: Compara forelimb morphogenesis Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara hindlimb morphogenesis Inferred from electronic annotation. Source: Compara magnesium ion homeostasis Inferred from electronic annotation. Source: Compara metanephric nephron development Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara phosphate ion homeostasis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara potassium ion homeostasis Inferred from electronic annotation. Source: Compara regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara renal water homeostasis Inferred from electronic annotation. Source: Compara sensory organ development Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara sodium ion homeostasis Inferred from electronic annotation. Source: Compara sympathetic nervous system development Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara RNA polymerase II transcription coactivator activity Inferred from electronic annotation. Source: Compara RNA polymerase II transcription corepressor activity Inferred from electronic annotation. Source: Compara cysteine-type endopeptidase inhibitor activity involved in apoptotic process Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8K557 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 4EF3DCC5E7273094	FASTA	449	49,270
	10 20 30 40 50 60 MLWKLVENVK YEDIYEDRHD GVPSHSSRLS QLGSVSQGPY SSAPPLSHTP SSDFQPPYFP 70 80 90 100 110 120 PPYQPLPYHQ SQDPYSHVND PYSLNPLHQP QQHPWGQRQR QEVGSEAGSL LPQPRAALPQ 130 140 150 160 170 180 LSGLDPRRDY HSVRRPDVLL HSAHHGLDAG MGDSLSLHGL GHPGMEDVQS VEDANNSGMN 190 200 210 220 230 240 LLDQSVIKKV PVPPKSVTSL MMNKDGFLGG MSVNTGEVFC SVPGRLSLLS STSKYKVTVG 250 260 270 280 290 300 EVQRRLSPPE CLNASLLGGV LRRAKSKNGG RSLRERLEKI GLNLPAGRRK AANVTLLTSL 310 320 330 340 350 360 VEGEAVHLAR DFGYICETEF PAKAVSEYLN RQHTDPSDLH SRKNMLLATK QLCKEFTDLL 370 380 390 400 410 420 AQDRTPIGNS RPSPILEPGI QSCLTHFSLI THGFGAPAIC AALTALQNYL TEALKGMDKM 430 440 FLNNTTTNRH TSGEGPGSKT GDKEEKHRK

References

[1]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK291172 mRNA. Translation: BAF83861.1.
IPI	IPI00021557.
UniGene	Hs.33102.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8K557.
Proteomic databases
PRIDE	A8K557.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002455.
Gene expression databases
ArrayExpress	A8K557.
Bgee	A8K557.
Family and domain databases
InterPro	IPR004979. TF_AP2. IPR008122. TF_AP2_beta. IPR013854. TF_AP2_C. [Graphical view]
PANTHER	PTHR10812. PTHR10812. 1 hit.
Pfam	PF03299. TF_AP-2. 1 hit. [Graphical view]
PRINTS	PR01750. AP2BTNSCPFCT. PR01748. AP2TNSCPFCT.
ProtoNet	Search...
Other
GenomeRNAi	7021.
NextBio	27431.

Entry information

Entry name

A8K557_HUMAN

Accession

Primary (citable) accession number: A8K557

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.