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Protein

CMRF35-like molecule 7

Gene

CD300LB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 7
Short name:
CLM-7
Alternative name(s):
CD300 antigen-like family member B
CMRF35-A2
Immune receptor expressed on myeloid cells 3
Short name:
IREM-3
Leukocyte mono-Ig-like receptor 5
Triggering receptor expressed on myeloid cells 5
Short name:
TREM-5
CD_antigen: CD300b
Gene namesi
Name:CD300LB
Synonyms:CD300B, CLM7, CMRF35A2, IREM3, LMIR5, TREM5
ORF Names:UNQ2530/PRO6029
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30811. CD300LB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 151134ExtracellularSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 20129CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi158 – 1581K → L: Abolishes interaction with TYROBP, and strongly reduces activation properties. 1 Publication
Mutagenesisi188 – 1881Y → F: No effect on interaction with TYROBP, but strongly reduces activation properties. 1 Publication

Organism-specific databases

PharmGKBiPA142672151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 201184CMRF35-like molecule 7PRO_0000320130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 104PROSITE-ProRule annotation
Modified residuei188 – 1881Phosphotyrosine; by FYN2 Publications

Post-translational modificationi

Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.2 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA8K4G0.
PRIDEiA8K4G0.

PTM databases

iPTMnetiA8K4G0.
PhosphoSiteiA8K4G0.

Expressioni

Tissue specificityi

Expressed exclusively in myeloid lineages.1 Publication

Gene expression databases

BgeeiENSG00000178789.
CleanExiHS_CD300LB.
ExpressionAtlasiA8K4G0. baseline and differential.
GenevisibleiA8K4G0. HS.

Organism-specific databases

HPAiCAB034924.

Interactioni

Subunit structurei

Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei158 – 1581Interaction with TYROBP

Protein-protein interaction databases

BioGridi125877. 1 interaction.
STRINGi9606.ENSP00000376397.

Structurei

3D structure databases

ProteinModelPortaliA8K4G0.
SMRiA8K4G0. Positions 14-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 120103Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JBZ0. Eukaryota.
ENOG41114E0. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG103081.
InParanoidiA8K4G0.
OMAiCFSIQGP.
OrthoDBiEOG091G0O8X.
PhylomeDBiA8K4G0.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8K4G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC
60 70 80 90 100
RGVRWDTCKI LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD
110 120 130 140 150
VYWCGIERRG PDLGTQVKVI VDPEGAASTT ASSPTNSNMA VFIGSHKRNH
160 170 180 190 200
YMLLVFVKVP ILLILVTAIL WLKGSQRVPE EPGEQPIYMN FSEPLTKDMA

T
Length:201
Mass (Da):22,689
Last modified:February 26, 2008 - v2
Checksum:i2B8027A488B97CAF
GO

Sequence cautioni

The sequence AAH28091 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF83614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW89170 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441G → R in AAV69612 (PubMed:16920917).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646929 mRNA. Translation: AAV69612.1.
AF427618 mRNA. Translation: AAN86133.1.
AY359025 mRNA. Translation: AAQ89384.1.
AK290925 mRNA. Translation: BAF83614.1. Different initiation.
AC079325 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89170.1. Different initiation.
BC028091 mRNA. Translation: AAH28091.1. Different initiation.
CCDSiCCDS11700.2.
RefSeqiNP_777552.3. NM_174892.3.
UniGeneiHs.313343.

Genome annotation databases

EnsembliENST00000392621; ENSP00000376397; ENSG00000178789.
GeneIDi124599.
KEGGihsa:124599.
UCSCiuc002jkx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646929 mRNA. Translation: AAV69612.1.
AF427618 mRNA. Translation: AAN86133.1.
AY359025 mRNA. Translation: AAQ89384.1.
AK290925 mRNA. Translation: BAF83614.1. Different initiation.
AC079325 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89170.1. Different initiation.
BC028091 mRNA. Translation: AAH28091.1. Different initiation.
CCDSiCCDS11700.2.
RefSeqiNP_777552.3. NM_174892.3.
UniGeneiHs.313343.

3D structure databases

ProteinModelPortaliA8K4G0.
SMRiA8K4G0. Positions 14-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125877. 1 interaction.
STRINGi9606.ENSP00000376397.

PTM databases

iPTMnetiA8K4G0.
PhosphoSiteiA8K4G0.

Proteomic databases

PaxDbiA8K4G0.
PRIDEiA8K4G0.

Protocols and materials databases

DNASUi124599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392621; ENSP00000376397; ENSG00000178789.
GeneIDi124599.
KEGGihsa:124599.
UCSCiuc002jkx.4. human.

Organism-specific databases

CTDi124599.
GeneCardsiCD300LB.
H-InvDBHIX0014146.
HGNCiHGNC:30811. CD300LB.
HPAiCAB034924.
MIMi610705. gene.
neXtProtiNX_A8K4G0.
PharmGKBiPA142672151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBZ0. Eukaryota.
ENOG41114E0. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG103081.
InParanoidiA8K4G0.
OMAiCFSIQGP.
OrthoDBiEOG091G0O8X.
PhylomeDBiA8K4G0.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

ChiTaRSiCD300LB. human.
GenomeRNAii124599.
PROiA8K4G0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178789.
CleanExiHS_CD300LB.
ExpressionAtlasiA8K4G0. baseline and differential.
GenevisibleiA8K4G0. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLM7_HUMAN
AccessioniPrimary (citable) accession number: A8K4G0
Secondary accession number(s): Q1EG73, Q8IX40, Q8N6D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.