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Protein
Submitted name:

cDNA FLJ78736, highly similar to Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465NucleophilePROSITE-ProRule annotation1
Active sitei598Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ78736, highly similar to Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiA8K460
PRIDEiA8K460

Expressioni

Gene expression databases

GenevisibleiA8K460 HS

Structurei

3D structure databases

ProteinModelPortaliA8K460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 395ANK_REP_REGIONInterPro annotationAdd BLAST245
Repeati151 – 184ANKPROSITE-ProRule annotationAdd BLAST34
Repeati219 – 251ANKPROSITE-ProRule annotationAdd BLAST33
Repeati316 – 348ANKPROSITE-ProRule annotationAdd BLAST33
Repeati349 – 381ANKPROSITE-ProRule annotationAdd BLAST33
Domaini427 – 611PNPLAInterPro annotationAdd BLAST185

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi431 – 436GXGXXGPROSITE-ProRule annotation6
Motifi463 – 467GXSXGPROSITE-ProRule annotation5
Motifi598 – 600DGA/GPROSITE-ProRule annotation3

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000013092
HOVERGENiHBG053482

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR002641 PNPLA_dom
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13606 Ank_3, 1 hit
PF01734 Patatin, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS51635 PNPLA, 1 hit

Sequencei

Sequence statusi: Complete.

A8K460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT
60 70 80 90 100
PNRTWDCVLV NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ
110 120 130 140 150
VLHTEVLQHL TDLIRNHPSW SVPHLAVELG IRECFHHSRI ISCANCAENE
160 170 180 190 200
EGCTPLHLAC RKGDGEILVE LVQYCHTQMD VTDYKGETVF HYAVQGDNSQ
210 220 230 240 250
VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL LCNARCNIMG
260 270 280 290 300
PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA
310 320 330 340 350
RMLLKRGCNV NSTSSAGSTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG
360 370 380 390 400
NTPLHLAMSK DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRQLQDL
410 420 430 440 450
MHISRARKPA FILGSMRDEK RTHDHLLCLD GGGVKGLIII QLLIAIEKAS
460 470 480 490 500
GVATKDLFDW VAGTSTGGIL ALAILHSKSM AYMRGMYFRM KDEVFRGSRP
510 520 530 540 550
YESGPLEEFL KREFGEHTKM TDVRKPKVML TGTLSDRQPA ELHLFRNYDA
560 570 580 590 600
PETVREPRFN QNVNLRPPAQ PSDQLVWRAA RSSGAAPTYF RPNGRFLDGG
610 620 630 640 650
LLANNPTLDA MTEIHEYNQD LIRKGQANKV KKLSIVVSLG TGRSPQVPVT
660 670 680 690 700
CVDVFRPSNP WELAKTVFGA KELGKMVVDC CTDPDGRAVD RARAWCEMVG
710 720 730 740 750
IQYFRLNPQL GTDIMLDEVS DTVLVNALWE TEVYIYEHRE EFQKLIQLLL

SP
Length:752
Mass (Da):84,092
Last modified:December 4, 2007 - v1
Checksum:i129099FF946D0D18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290825 mRNA Translation: BAF83514.1
UniGeneiHs.170479
Hs.641914

Similar proteinsi

Entry informationi

Entry nameiA8K460_HUMAN
AccessioniPrimary (citable) accession number: A8K460
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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