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A8K3Z4 (A8K3Z4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor RuleBase RU000312
EC=2.7.10.1 RuleBase RU000312
OrganismHomo sapiens (Human) EMBL BAF83448.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU000312 SAAS SAAS002011

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. RuleBase RU000312

Contains 1 protein kinase domain. SAAS SAAS002011

Sequences

Sequence LengthMass (Da)Tools
A8K3Z4 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 650A2BA4532565B2

FASTA79387,096
        10         20         30         40         50         60 
MLRGGRRGQL GWHSWAAGAG SLLAWLILAS AGASPCPDAC CPHGSSGLRC TRDGALDSLH 

        70         80         90        100        110        120 
HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL 

       130        140        150        160        170        180 
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ 

       190        200        210        220        230        240 
GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK 

       250        260        270        280        290        300 
SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC 

       310        320        330        340        350        360 
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT 

       370        380        390        400        410        420 
LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPDTNSTSGD PVEKKDETPF GVSVAVGLAV 

       430        440        450        460        470        480 
FACLFLSTLL LVLNKCGRRN KFGINRPAVL APEDGLAMSL HFMTLGGSSL SPTEGKGSGL 

       490        500        510        520        530        540 
QGHIIENPQY FSDASPSGVH HIKRRDIVLK WELGEGAFGK VFLAECHNLL PEQDKMLVAV 

       550        560        570        580        590        600 
KALKEASESA RQDFQREAEL LTMLQHQHIV RFFGVCTEGR PLLMVFEYMR HGDLNRFLRS 

       610        620        630        640        650        660 
HGPDAKLLAG GEDVAPGPLG LGQLLAVASQ VAAGMVYLAG LHFVHRDLAT RNCLVGQGLV 

       670        680        690        700        710        720 
VKIGDFGMSR DIYSTDYYRV GGRTMLPIRW MPPESILYRK FTTESDVWSF GVVLWEIFTY 

       730        740        750        760        770        780 
GKQPWYQLSN TEAIDCITQG RELERPRACP PEVYAIMRGC WQREPQQRHS IKDVHARLQA 

       790 
LAQAPPVYLD VLG

« Hide

References

[1]"NEDO human cDNA sequencing project."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK290759 mRNA. Translation: BAF83448.1.
IPIIPI00025076.
UniGeneHs.406293.

3D structure databases

ProteinModelPortalA8K3Z4.
SMRA8K3Z4. Positions 36-382.
ModBaseSearch...

Proteomic databases

PRIDEA8K3Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009wsk.1. human.

Phylogenomic databases

HOGENOMHOG000264255.
HOVERGENHBG056735.
OrthoDBEOG4J3WGJ.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35464073.

Entry information

Entry nameA8K3Z4_HUMAN
AccessionPrimary (citable) accession number: A8K3Z4
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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