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Protein
Submitted name:

Mitogen-activated protein kinase kinase 6

Gene

MAP2K6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase 6Imported
Submitted name:
Mitogen-activated protein kinase kinase 6, isoform CRA_bImported
Submitted name:
cDNA FLJ75671, highly similar to Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6), transcript variant 1, mRNAImported
Gene namesi
Name:MAP2K6Imported
ORF Names:hCG_28772Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30591.

Expressioni

Gene expression databases

BgeeiENSG00000108984.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000468348.

Structurei

3D structure databases

SMRiA8K3Y2. Positions 44-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 314262Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOVERGENiHBG108518.
KOiK04433.
OMAiEDFIATC.
OrthoDBiEOG091G0A9H.
PhylomeDBiA8K3Y2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K3Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA
60 70 80 90 100
DDLEPIMELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL
110 120 130 140 150
DISMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI
160 170 180 190 200
PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINAL GQVKMCDFGI
210 220 230 240 250
SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL
260 270 280 290 300
AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK
310 320 330
ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD
Length:334
Mass (Da):37,492
Last modified:December 4, 2007 - v1
Checksum:i4ECA8014522216AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei334 – 3341Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332850 Genomic DNA. Translation: ABY87539.1.
JX512448 Genomic DNA. Translation: AGC09595.1.
AK290747 mRNA. Translation: BAF83436.1.
AB451376 mRNA. Translation: BAG70190.1.
CH471099 Genomic DNA. Translation: EAW89085.1.
RefSeqiNP_002749.2. NM_002758.3.
UniGeneiHs.463978.

Genome annotation databases

GeneIDi5608.
KEGGihsa:5608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332850 Genomic DNA. Translation: ABY87539.1.
JX512448 Genomic DNA. Translation: AGC09595.1.
AK290747 mRNA. Translation: BAF83436.1.
AB451376 mRNA. Translation: BAG70190.1.
CH471099 Genomic DNA. Translation: EAW89085.1.
RefSeqiNP_002749.2. NM_002758.3.
UniGeneiHs.463978.

3D structure databases

SMRiA8K3Y2. Positions 44-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000468348.

Protocols and materials databases

DNASUi5608.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5608.
KEGGihsa:5608.

Organism-specific databases

CTDi5608.
PharmGKBiPA30591.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOVERGENiHBG108518.
KOiK04433.
OMAiEDFIATC.
OrthoDBiEOG091G0A9H.
PhylomeDBiA8K3Y2.

Miscellaneous databases

ChiTaRSiMAP2K6. human.
GenomeRNAii5608.

Gene expression databases

BgeeiENSG00000108984.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K3Y2_HUMAN
AccessioniPrimary (citable) accession number: A8K3Y2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.