UniProtKB - A8K3H3 (A8K3H3_HUMAN)
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Protein
Submitted name:
Retinoic acid nuclear receptor gamma variant 1
Gene
NR1B3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 87 – 162 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 |
GO - Molecular functioni
- retinoic acid receptor activity Source: Ensembl
- retinoid X receptor binding Source: Ensembl
- RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- cellular response to leukemia inhibitory factor Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- embryonic camera-type eye development Source: Ensembl
- embryonic eye morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- face development Source: Ensembl
- glandular epithelial cell development Source: Ensembl
- growth plate cartilage chondrocyte growth Source: Ensembl
- Harderian gland development Source: Ensembl
- multicellular organism growth Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cell proliferation Source: Ensembl
- negative regulation of chondrocyte differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural tube closure Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- prostate gland epithelium morphogenesis Source: Ensembl
- regulation of myelination Source: Ensembl
- regulation of myeloid cell differentiation Source: Ensembl
- retinal pigment epithelium development Source: Ensembl
- trachea cartilage development Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported |
Biological process | Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Retinoic acid nuclear receptor gamma variant 1ImportedSubmitted name: Retinoic acid receptor gammaImportedSubmitted name: Retinoic acid receptor, gamma, isoform CRA_bImportedSubmitted name: cDNA FLJ75202, highly similar to Homo sapiens, retinoic acid receptor, gammaImported |
Gene namesi | Name:NR1B3Imported Synonyms:RARGImported ORF Names:hCG_31521Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172819.16 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 162 | Nuclear receptorInterPro annotationAdd BLAST | 76 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG3575 Eukaryota ENOG410XRZC LUCA |
HOVERGENi | HBG005606 |
KOi | K08529 |
OMAi | NKERLFV |
OrthoDBi | EOG091G0XCQ |
Family and domain databases
Gene3Di | 3.30.50.101 hit |
InterProi | View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8K3H3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG
60 70 80 90 100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY
110 120 130 140 150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC
160 170 180 190 200
FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET
210 220 230 240 250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG
260 270 280 290 300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH
310 320 330 340 350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV
360 370 380 390 400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL
410 420 430 440 450
KMEIPGPMPP LIREMLENPE MFEDDSSQPG PHPNASSEDE VPGGQGKGGL
KSPA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692828 mRNA Translation: ADZ17339.1 AK290588 mRNA Translation: BAF83277.1 AB307689 mRNA Translation: BAH02280.1 CH471054 Genomic DNA Translation: EAW96677.1 CH471054 Genomic DNA Translation: EAW96678.1 |
RefSeqi | NP_000957.1, NM_000966.5 |
UniGenei | Hs.1497 Hs.733399 |
Genome annotation databases
GeneIDi | 5916 |
KEGGi | hsa:5916 |
Similar proteinsi
Entry informationi
Entry namei | A8K3H3_HUMAN | |
Accessioni | A8K3H3Primary (citable) accession number: A8K3H3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | March 28, 2018 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |