NR1B3

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	87 – 162	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

retinoic acid receptor activity Source: Ensembl
retinoid X receptor binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
cellular response to retinoic acid Source: Ensembl
embryonic camera-type eye development Source: Ensembl
embryonic eye morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
face development Source: Ensembl
glandular epithelial cell development Source: Ensembl
growth plate cartilage chondrocyte growth Source: Ensembl
Harderian gland development Source: Ensembl
multicellular organism growth Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of chondrocyte differentiation Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
neural tube closure Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
prostate gland epithelium morphogenesis Source: Ensembl
regulation of myelination Source: Ensembl
regulation of myeloid cell differentiation Source: Ensembl
retinal pigment epithelium development Source: Ensembl
trachea cartilage development Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Retinoic acid nuclear receptor gamma variant 1Imported Submitted name: Retinoic acid receptor gammaImported Submitted name: Retinoic acid receptor, gamma, isoform CRA_bImported Submitted name: cDNA FLJ75202, highly similar to Homo sapiens, retinoic acid receptor, gammaImported
Gene namesⁱ	Name:NR1B3Imported Synonyms:RARGImported ORF Names:hCG_31521Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00407
- RuleBase:RU004334
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00817906

GO - Cellular componentⁱ

nuclear chromatin Source: Ensembl
nucleoplasm Source: HPA
transcription factor complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA34227.

PharmGKBⁱ

PA34227.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172819.
ExpressionAtlasⁱ	A8K3H3. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

retinoid X receptor binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	A8K3H3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	87 – 162	Nuclear receptor DNA-bindingInterPro annotationAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
HOVERGENⁱ	HBG005606.
KEGG Orthology (KO) More...KOⁱ	K08529.
OMAⁱ	NKERLFV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XCQ.

Family and domain databases

Gene3Dⁱ	3.30.50.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000536. Nucl_hrmn_rcpt_lig-bd. IPR001723. Nuclear_hrmn_rcpt. IPR003078. Retinoic_acid_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR01292. RETNOICACIDR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit.
SUPFAMⁱ	SSF48508. SSF48508. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A8K3H3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG 
        60         70         80         90        100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY 
       110        120        130        140        150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC 
       160        170        180        190        200
FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET 
       210        220        230        240        250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG 
       260        270        280        290        300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 
       310        320        330        340        350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV 
       360        370        380        390        400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL 
       410        420        430        440        450
KMEIPGPMPP LIREMLENPE MFEDDSSQPG PHPNASSEDE VPGGQGKGGL 

KSPA

Length:454

Mass (Da):50,342

Last modified:December 4, 2007 - v1

Checksum:ⁱ1EE27B22772D4AFD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692828 mRNA. Translation: ADZ17339.1. AK290588 mRNA. Translation: BAF83277.1. AB307689 mRNA. Translation: BAH02280.1. CH471054 Genomic DNA. Translation: EAW96677.1. CH471054 Genomic DNA. Translation: EAW96678.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_000957.1. NM_000966.5.
UniGeneⁱ	Hs.1497. Hs.733399.

Genome annotation databases

GeneIDⁱ	5916.
KEGGⁱ	hsa:5916.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692828 mRNA. Translation: ADZ17339.1. AK290588 mRNA. Translation: BAF83277.1. AB307689 mRNA. Translation: BAH02280.1. CH471054 Genomic DNA. Translation: EAW96677.1. CH471054 Genomic DNA. Translation: EAW96678.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_000957.1. NM_000966.5.
UniGeneⁱ	Hs.1497. Hs.733399.

3D structure databases

SMRⁱ	A8K3H3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5916.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	5916.
KEGGⁱ	hsa:5916.

Organism-specific databases

CTDⁱ	5916.
PharmGKBⁱ	PA34227.

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
HOVERGENⁱ	HBG005606.
KEGG Orthology (KO) More...KOⁱ	K08529.
OMAⁱ	NKERLFV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XCQ.

Miscellaneous databases

ChiTaRSⁱ	RARG. human.
GenomeRNAiⁱ	5916.

Gene expression databases

Bgeeⁱ	ENSG00000172819.
ExpressionAtlasⁱ	A8K3H3. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.30.50.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000536. Nucl_hrmn_rcpt_lig-bd. IPR001723. Nuclear_hrmn_rcpt. IPR003078. Retinoic_acid_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR01292. RETNOICACIDR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit.
SUPFAMⁱ	SSF48508. SSF48508. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8K3H3_HUMAN
Accessionⁱ	A8K3H3Primary (citable) accession number: A8K3H3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	July 5, 2017
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A8K3H3 (A8K3H3_HUMAN)

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Retinoic acid nuclear receptor gamma variant 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ