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Protein
Submitted name:

cDNA FLJ78524, highly similar to Homo sapiens SMILE protein (SMILE), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ78524, highly similar to Homo sapiens SMILE protein (SMILE), mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 115HelicalSequence analysisAdd BLAST22
Transmembranei135 – 157HelicalSequence analysisAdd BLAST23
Transmembranei169 – 186HelicalSequence analysisAdd BLAST18
Transmembranei192 – 215HelicalSequence analysisAdd BLAST24
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei318 – 336HelicalSequence analysisAdd BLAST19
Transmembranei348 – 371HelicalSequence analysisAdd BLAST24
Transmembranei377 – 393HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670720.

PTM / Processingi

Proteomic databases

PaxDbiA8K321.
PeptideAtlasiA8K321.
PRIDEiA8K321.

Expressioni

Gene expression databases

GenevisibleiA8K321. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266712.

Structurei

3D structure databases

ProteinModelPortaliA8K321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 804TPR_REGIONInterPro annotationAdd BLAST393

Keywords - Domaini

RepeatSAAS annotation, TPR repeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG094080.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 6 hits.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANINLKEIT LIVGVVTACY WNSLFCGFVF DDVSAILDNK DLHPSTPLKT
60 70 80 90 100
LFQNDFWGTP MSEERSHKSY RPLTVLTFRL NYLLSELKPM SYHLLNMIFH
110 120 130 140 150
AVVSVIFLKV CKLFLDNKSS VIASLLFAVH PIHTEAVTGV VGRAELLSSI
160 170 180 190 200
FFLAAFLSYT RSKGPDNSII WTPIALTVFL VAVATLCKEQ GITVVGICCV
210 220 230 240 250
YEVFIAQGYT LPLLCTTAGQ FLRGKGSIPF SMLQTLVKLI VLMFSTLLLV
260 270 280 290 300
VIRVQVIQSQ LPVFTRFDNP AAVSPTPTRQ LTFNYLLPVN AWLLLNPSEL
310 320 330 340 350
CCDWTMGTIP LIESLLDIRN LATFTFFCFL GMLGVFSIRY SGDSSKTVLM
360 370 380 390 400
ALCLMALPFI PASNLFFPVG FVVAERVLYV PSMGFCILVA HGWQKISTKS
410 420 430 440 450
VFKKLSWICL SMVILTHSLK TFHRNWDWES EYTLFMSALK VNKNNAKLWN
460 470 480 490 500
NVGHALENEK NFERALKYFL QATHVQPDDI GAHMNVGRTY KNLNRTKEAE
510 520 530 540 550
ESYMMAKSLM PQIIPGKKYA ARIAPNHLNV YINLANLIRA NESRLEEADQ
560 570 580 590 600
LYRQAISMRP DFKQAYISRG ELLLKMNKPL KAKEAYLKAL ELDRNNADLW
610 620 630 640 650
YNLAIVHIEL KEPNEALKNF NRALELNPKH KLALFNSAIV MQESGEVKLR
660 670 680 690 700
PEARKRLLSY INEEPLDANG YFNLGMLAMD DKKDNEAEIW MKKAIKLQAD
710 720 730 740 750
FRSALFNLAL LYSQTAKELK ALPILEELLR YYPDHIKGLI LKGDILMNQK
760 770 780 790 800
KDILGAKKCF ERILEMDPSN VQGKHNLCVV YFEEKDLLKA ERCLLETLAL
810 820 830 840 850
APHEEYIQRH LNIVRDKISS SSFIEPIFPT SKISSVEGKK IPTESVKEIR
860 870 880 890
GESRQTQIVK TSDNKSQSKS NKQLGKNGDE ETPHKTTKDI KEIEKKPAA
Length:899
Mass (Da):102,028
Last modified:December 4, 2007 - v1
Checksum:i121004D29722CC50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290436 mRNA. Translation: BAF83125.1.
RefSeqiNP_861448.2. NM_181783.3.
UniGeneiHs.331268.

Genome annotation databases

GeneIDi160418.
KEGGihsa:160418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290436 mRNA. Translation: BAF83125.1.
RefSeqiNP_861448.2. NM_181783.3.
UniGeneiHs.331268.

3D structure databases

ProteinModelPortaliA8K321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266712.

Proteomic databases

PaxDbiA8K321.
PeptideAtlasiA8K321.
PRIDEiA8K321.

Protocols and materials databases

DNASUi160418.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi160418.
KEGGihsa:160418.

Organism-specific databases

CTDi160418.
PharmGKBiPA142670720.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
HOVERGENiHBG094080.

Miscellaneous databases

GenomeRNAii160418.

Gene expression databases

GenevisibleiA8K321. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013618. DUF1736.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08409. DUF1736. 1 hit.
PF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 6 hits.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K321_HUMAN
AccessioniPrimary (citable) accession number: A8K321
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.