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A8K2U0

- A2ML1_HUMAN

UniProt

A8K2U0 - A2ML1_HUMAN

Protein

Alpha-2-macroglobulin-like protein 1

Gene

A2ML1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase By similarity. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.By similarity1 Publication

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: UniProtKB
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of endopeptidase activity Source: UniProtKB

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI39.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2-macroglobulin-like protein 1
    Alternative name(s):
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9
    Gene namesi
    Name:A2ML1Imported
    Synonyms:CPAMD9Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:23336. A2ML1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 14541437Alpha-2-macroglobulin-like protein 1Sequence AnalysisPRO_0000318074Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 78By similarity
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi241 ↔ 291By similarity
    Disulfide bondi259 ↔ 279By similarity
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi464 ↔ 557By similarity
    Disulfide bondi589 ↔ 769By similarity
    Disulfide bondi819 ↔ 847By similarity
    Disulfide bondi845 ↔ 881By similarity
    Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi919 ↔ 1307By similarity
    Cross-linki970 ↔ 973Isoglutamyl cysteine thioester (Cys-Gln)By similarity
    Glycosylationi1020 – 10201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1075 ↔ 1123By similarity
    Disulfide bondi1338 ↔ 1453By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Thioester bond

    Proteomic databases

    MaxQBiA8K2U0.
    PaxDbiA8K2U0.
    PRIDEiA8K2U0.

    PTM databases

    PhosphoSiteiA8K2U0.

    Expressioni

    Tissue specificityi

    In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.1 Publication

    Developmental stagei

    Up-regulated during keratinocyte differentiation.1 Publication

    Gene expression databases

    ArrayExpressiA8K2U0.
    BgeeiA8K2U0.
    CleanExiHS_A2ML1.
    GenevestigatoriA8K2U0.

    Organism-specific databases

    HPAiHPA038847.
    HPA038848.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    IntActiA8K2U0. 1 interaction.
    STRINGi9606.ENSP00000299698.

    Structurei

    3D structure databases

    ProteinModelPortaliA8K2U0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni695 – 72632Bait regionSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    HOVERGENiHBG000039.
    OMAiATGIVAW.
    OrthoDBiEOG7DJSKB.
    PhylomeDBiA8K2U0.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8K2U0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWAQLLLGML ALSPAIAEEL PNYLVTLPAR LNFPSVQKVC LDLSPGYSDV     50
    KFTVTLETKD KTQKLLEYSG LKKRHLHCIS FLVPPPAGGT EEVATIRVSG 100
    VGNNISFEEK KKVLIQRQGN GTFVQTDKPL YTPGQQVYFR IVTMDSNFVP 150
    VNDKYSMVEL QDPNSNRIAQ WLEVVPEQGI VDLSFQLAPE AMLGTYTVAV 200
    AEGKTFGTFS VEEYVLPKFK VEVVEPKELS TVQESFLVKI CCRYTYGKPM 250
    LGAVQVSVCQ KANTYWYREV EREQLPDKCR NLSGQTDKTG CFSAPVDMAT 300
    FDLIGYAYSH QINIVATVVE EGTGVEANAT QNIYISPQMG SMTFEDTSNF 350
    YHPNFPFSGK IRVRGHDDSF LKNHLVFLVI YGTNGTFNQT LVTDNNGLAP 400
    FTLETSGWNG TDVSLEGKFQ MEDLVYNPEQ VPRYYQNAYL HLRPFYSTTR 450
    SFLGIHRLNG PLKCGQPQEV LVDYYIDPAD ASPDQEISFS YYLIGKGSLV 500
    MEGQKHLNSK KKGLKASFSL SLTFTSRLAP DPSLVIYAIF PSGGVVADKI 550
    QFSVEMCFDN QVSLGFSPSQ QLPGAEVELQ LQAAPGSLCA LRAVDESVLL 600
    LRPDRELSNR SVYGMFPFWY GHYPYQVAEY DQCPVSGPWD FPQPLIDPMP 650
    QGHSSQRSII WRPSFSEGTD LFSFFRDVGL KILSNAKIKK PVDCSHRSPE 700
    YSTAMGAGGG HPEAFESSTP LHQAEDSQVR QYFPETWLWD LFPIGNSGKE 750
    AVHVTVPDAI TEWKAMSFCT SQSRGFGLSP TVGLTAFKPF FVDLTLPYSV 800
    VRGESFRLTA TIFNYLKDCI RVQTDLAKSH EYQLESWADS QTSSCLCADD 850
    AKTHHWNITA VKLGHINFTI STKILDSNEP CGGQKGFVPQ KGRSDTLIKP 900
    VLVKPEGVLV EKTHSSLLCP KGKVASESVS LELPVDIVPD STKAYVTVLG 950
    DIMGTALQNL DGLVQMPSGC GEQNMVLFAP IIYVLQYLEK AGLLTEEIRS 1000
    RAVGFLEIGY QKELMYKHSN GSYSAFGERD GNGNTWLTAF VTKCFGQAQK 1050
    FIFIDPKNIQ DALKWMAGNQ LPSGCYANVG NLLHTAMKGG VDDEVSLTAY 1100
    VTAALLEMGK DVDDPMVSQG LRCLKNSATS TTNLYTQALL AYIFSLAGEM 1150
    DIRNILLKQL DQQAIISGES IYWSQKPTPS SNASPWSEPA AVDVELTAYA 1200
    LLAQLTKPSL TQKEIAKATS IVAWLAKQHN AYGGFSSTQD TVVALQALAK 1250
    YATTAYMPSE EINLVVKSTE NFQRTFNIQS VNRLVFQQDT LPNVPGMYTL 1300
    EASGQGCVYV QTVLRYNILP PTNMKTFSLS VEIGKARCEQ PTSPRSLTLT 1350
    IHTSYVGSRS SSNMAIVEVK MLSGFSPMEG TNQLLLQQPL VKKVEFGTDT 1400
    LNIYLDELIK NTQTYTFTIS QSVLVTNLKP ATIKVYDYYL PDEQATIQYS 1450
    DPCE 1454
    Length:1,454
    Mass (Da):161,107
    Last modified:October 5, 2010 - v3
    Checksum:i15ED65D000834E33
    GO

    Sequence cautioni

    The sequence BAB71612.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC04793.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC85653.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC85654.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti733 – 7331F → L in BAC85654. (PubMed:14702039)Curated
    Sequence conflicti733 – 7331F → L in BAF83044. (PubMed:14702039)Curated
    Sequence conflicti748 – 7481G → E in AL832139. (PubMed:17974005)Curated
    Sequence conflicti1122 – 11221R → W in BAC04793. (PubMed:14702039)Curated
    Sequence conflicti1122 – 11221R → W in BAC85653. (PubMed:14702039)Curated
    Sequence conflicti1122 – 11221R → W in BAC85654. (PubMed:14702039)Curated
    Sequence conflicti1122 – 11221R → W in BAF83044. (PubMed:14702039)Curated
    Sequence conflicti1122 – 11221R → W in AL832139. (PubMed:17974005)Curated
    Sequence conflicti1150 – 11501M → I in BAF83044. (PubMed:14702039)Curated
    Sequence conflicti1248 – 12481L → P in BAC85654. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571M → V in BAC04793. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571M → V in BAC85653. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571M → V in BAC85654. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571M → V in BAF83044. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571M → V in AL832139. (PubMed:17974005)Curated
    Sequence conflicti1452 – 14521P → L in AL832139. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti207 – 2071G → R.
    Corresponds to variant rs11047499 [ dbSNP | Ensembl ].
    VAR_055463
    Natural varianti850 – 8501D → E.2 Publications
    Corresponds to variant rs1860926 [ dbSNP | Ensembl ].
    VAR_059083
    Natural varianti970 – 9701C → Y.
    Corresponds to variant rs1558526 [ dbSNP | Ensembl ].
    VAR_055464
    Natural varianti1131 – 11311T → M.
    Corresponds to variant rs7959680 [ dbSNP | Ensembl ].
    VAR_055465
    Natural varianti1229 – 12291H → R.2 Publications
    Corresponds to variant rs10219561 [ dbSNP | Ensembl ].
    VAR_059084
    Natural varianti1412 – 14121T → A.
    Corresponds to variant rs7315591 [ dbSNP | Ensembl ].
    VAR_055466

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057908 mRNA. Translation: BAB71612.1. Different initiation.
    AK096448 mRNA. Translation: BAC04793.1. Different initiation.
    AK123591 mRNA. Translation: BAC85653.1. Different initiation.
    AK123592 mRNA. Translation: BAC85654.1. Different initiation.
    AK290355 mRNA. Translation: BAF83044.1.
    AL832139 mRNA. No translation available.
    AC006513 Genomic DNA. No translation available.
    AC006581 Genomic DNA. No translation available.
    BC093840 mRNA. Translation: AAH93840.2.
    BC112131 mRNA. Translation: AAI12132.1.
    CCDSiCCDS8596.2.
    UniGeneiHs.620532.

    Genome annotation databases

    EnsembliENST00000299698; ENSP00000299698; ENSG00000166535.
    UCSCiuc001quz.5. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057908 mRNA. Translation: BAB71612.1 . Different initiation.
    AK096448 mRNA. Translation: BAC04793.1 . Different initiation.
    AK123591 mRNA. Translation: BAC85653.1 . Different initiation.
    AK123592 mRNA. Translation: BAC85654.1 . Different initiation.
    AK290355 mRNA. Translation: BAF83044.1 .
    AL832139 mRNA. No translation available.
    AC006513 Genomic DNA. No translation available.
    AC006581 Genomic DNA. No translation available.
    BC093840 mRNA. Translation: AAH93840.2 .
    BC112131 mRNA. Translation: AAI12132.1 .
    CCDSi CCDS8596.2.
    UniGenei Hs.620532.

    3D structure databases

    ProteinModelPortali A8K2U0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A8K2U0. 1 interaction.
    STRINGi 9606.ENSP00000299698.

    Protein family/group databases

    MEROPSi I39.007.

    PTM databases

    PhosphoSitei A8K2U0.

    Proteomic databases

    MaxQBi A8K2U0.
    PaxDbi A8K2U0.
    PRIDEi A8K2U0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299698 ; ENSP00000299698 ; ENSG00000166535 .
    UCSCi uc001quz.5. human.

    Organism-specific databases

    GeneCardsi GC12P008975.
    HGNCi HGNC:23336. A2ML1.
    HPAi HPA038847.
    HPA038848.
    MIMi 610627. gene.
    neXtProti NX_A8K2U0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2373.
    HOVERGENi HBG000039.
    OMAi ATGIVAW.
    OrthoDBi EOG7DJSKB.
    PhylomeDBi A8K2U0.
    TreeFami TF313285.

    Miscellaneous databases

    ChiTaRSi A2ML1. human.
    PROi A8K2U0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A8K2U0.
    Bgeei A8K2U0.
    CleanExi HS_A2ML1.
    Genevestigatori A8K2U0.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-850 AND ARG-1229.
      Tissue: BrainImported and TongueImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-850 AND ARG-1229.
      Tissue: Cervix.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-1454.
      Tissue: BrainImported.
    5. "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis."
      Galliano M.-F., Toulza E., Gallinaro H., Jonca N., Ishida-Yamamoto A., Serre G., Guerrin M.
      J. Biol. Chem. 281:5780-5789(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiA2ML1_HUMAN
    AccessioniPrimary (citable) accession number: A8K2U0
    Secondary accession number(s): B5MDD1
    , Q2M224, Q6ZW52, Q6ZW53, Q8N1M4, Q96LQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 56 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3