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Protein
Submitted name:

Proteasome (Prosome, macropain) 26S subunit, ATPase, 4, isoform CRA_b

Gene

PSMC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, ATPase, 4, isoform CRA_bImported
Submitted name:
cDNA FLJ78505, highly similar to Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4), transcript variant 1, mRNAImported
Submitted name:
cDNA, FLJ93682, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4(PSMC4), transcript variant 1, mRNAImported
Gene namesi
Name:PSMC4Imported
ORF Names:hCG_43346Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ProteasomeImported

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33896.

Expressioni

Gene expression databases

BgeeiENSG00000013275.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000157812.

Structurei

3D structure databases

SMRiA8K2M0. Positions 41-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 337140AAAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili37 – 7135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0727. Eukaryota.
COG1222. LUCA.
HOVERGENiHBG000109.
KOiK03063.
OMAiGYKNNTK.
OrthoDBiEOG091G07NC.
PhylomeDBiA8K2M0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K2M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE
60 70 80 90 100
LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT
110 120 130 140 150
AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS
160 170 180 190 200
IMMLTSDQKP DVMYADIGGM DIQKQEVREA VELPLTHFEL YKQIGIDPPR
210 220 230 240 250
GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL GEGPRMVRDV
260 270 280 290 300
FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD
310 320 330 340 350
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS
360 370 380 390 400
KMNLSEEVDL EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE
410
KAYKTVIKKD EQEHEFYK
Length:418
Mass (Da):47,366
Last modified:December 4, 2007 - v1
Checksum:i80F9523C61B88F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290285 mRNA. Translation: BAF82974.1.
AK313183 mRNA. Translation: BAG36000.1.
CH471126 Genomic DNA. Translation: EAW56929.1.
RefSeqiNP_006494.1. NM_006503.3.
UniGeneiHs.211594.

Genome annotation databases

GeneIDi5704.
KEGGihsa:5704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290285 mRNA. Translation: BAF82974.1.
AK313183 mRNA. Translation: BAG36000.1.
CH471126 Genomic DNA. Translation: EAW56929.1.
RefSeqiNP_006494.1. NM_006503.3.
UniGeneiHs.211594.

3D structure databases

SMRiA8K2M0. Positions 41-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000157812.

Protocols and materials databases

DNASUi5704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5704.
KEGGihsa:5704.

Organism-specific databases

CTDi5704.
PharmGKBiPA33896.

Phylogenomic databases

eggNOGiKOG0727. Eukaryota.
COG1222. LUCA.
HOVERGENiHBG000109.
KOiK03063.
OMAiGYKNNTK.
OrthoDBiEOG091G07NC.
PhylomeDBiA8K2M0.

Miscellaneous databases

ChiTaRSiPSMC4. human.
GenomeRNAii5704.

Gene expression databases

BgeeiENSG00000013275.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K2M0_HUMAN
AccessioniPrimary (citable) accession number: A8K2M0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.