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Protein
Submitted name:

Complement component 3a receptor 1, isoform CRA_a

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 3a receptor 1, isoform CRA_aImported
Submitted name:
cDNA FLJ78205, highly similar to Homo sapiens complement component 3a receptor 1, mRNAImported
Submitted name:
cDNA, FLJ92813, Homo sapiens complement component 3a receptor 1 (C3AR1), mRNAImported
Gene namesi
Name:C3AR1Imported
ORF Names:hCG_22220Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 47HelicalSequence analysisAdd BLAST25
Transmembranei59 – 77HelicalSequence analysisAdd BLAST19
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Transmembranei139 – 160HelicalSequence analysisAdd BLAST22
Transmembranei341 – 363HelicalSequence analysisAdd BLAST23
Transmembranei375 – 396HelicalSequence analysisAdd BLAST22
Transmembranei416 – 438HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25898.

Expressioni

Gene expression databases

BgeeiENSG00000171860.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302079.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 435G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST396

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
HOVERGENiHBG002433.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K2H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI
210 220 230 240 250
VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT
260 270 280 290 300
SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
310 320 330 340 350
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV
360 370 380 390 400
IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS
410 420 430 440 450
LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI
460 470 480
QGILEAAFSE ELTRSTHCPS NNVISERNST TV
Length:482
Mass (Da):53,864
Last modified:December 4, 2007 - v1
Checksum:i287E219D98CED203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290242 mRNA. Translation: BAF82931.1.
AK312458 mRNA. Translation: BAG35365.1.
CH471116 Genomic DNA. Translation: EAW88640.1.
CH471116 Genomic DNA. Translation: EAW88641.1.
RefSeqiNP_001313404.1. NM_001326475.1.
NP_001313406.1. NM_001326477.1.
NP_004045.1. NM_004054.3.
UniGeneiHs.504656.
Hs.591148.

Genome annotation databases

GeneIDi719.
KEGGihsa:719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290242 mRNA. Translation: BAF82931.1.
AK312458 mRNA. Translation: BAG35365.1.
CH471116 Genomic DNA. Translation: EAW88640.1.
CH471116 Genomic DNA. Translation: EAW88641.1.
RefSeqiNP_001313404.1. NM_001326475.1.
NP_001313406.1. NM_001326477.1.
NP_004045.1. NM_004054.3.
UniGeneiHs.504656.
Hs.591148.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302079.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

DNASUi719.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi719.
KEGGihsa:719.

Organism-specific databases

CTDi719.
PharmGKBiPA25898.

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
HOVERGENiHBG002433.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.

Miscellaneous databases

ChiTaRSiC3AR1. human.
GenomeRNAii719.

Gene expression databases

BgeeiENSG00000171860.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K2H7_HUMAN
AccessioniPrimary (citable) accession number: A8K2H7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.