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A8K2H7

- A8K2H7_HUMAN

UniProt

A8K2H7 - A8K2H7_HUMAN

Protein
Submitted name:

Complement component 3a receptor 1, isoform CRA_a

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. C3a anaphylatoxin receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. positive regulation of angiogenesis Source: Ensembl
    3. positive regulation of macrophage chemotaxis Source: Ensembl
    4. positive regulation of neutrophil chemotaxis Source: Ensembl
    5. positive regulation vascular endothelial growth factor production Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Complement component 3a receptor 1, isoform CRA_aImported
    Submitted name:
    cDNA FLJ78205, highly similar to Homo sapiens complement component 3a receptor 1, mRNAImported
    Submitted name:
    cDNA, FLJ92813, Homo sapiens complement component 3a receptor 1 (C3AR1), mRNAImported
    Gene namesi
    Name:C3AR1Imported
    ORF Names:hCG_22220Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25898.

    Structurei

    3D structure databases

    SMRiA8K2H7. Positions 29-187, 310-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG002433.
    KOiK04009.
    OMAiLWVAGLK.
    PhylomeDBiA8K2H7.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 2 hits.
    [Graphical view]
    PRINTSiPR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8K2H7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL    50
    KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS 100
    IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA 150
    FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI 200
    VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT 250
    SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 300
    SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV 350
    IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS 400
    LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI 450
    QGILEAAFSE ELTRSTHCPS NNVISERNST TV 482
    Length:482
    Mass (Da):53,864
    Last modified:December 4, 2007 - v1
    Checksum:i287E219D98CED203
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290242 mRNA. Translation: BAF82931.1.
    AK312458 mRNA. Translation: BAG35365.1.
    CH471116 Genomic DNA. Translation: EAW88640.1.
    CH471116 Genomic DNA. Translation: EAW88641.1.
    RefSeqiNP_004045.1. NM_004054.2.
    UniGeneiHs.591148.

    Genome annotation databases

    GeneIDi719.
    KEGGihsa:719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290242 mRNA. Translation: BAF82931.1 .
    AK312458 mRNA. Translation: BAG35365.1 .
    CH471116 Genomic DNA. Translation: EAW88640.1 .
    CH471116 Genomic DNA. Translation: EAW88641.1 .
    RefSeqi NP_004045.1. NM_004054.2.
    UniGenei Hs.591148.

    3D structure databases

    SMRi A8K2H7. Positions 29-187, 310-448.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    DNASUi 719.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 719.
    KEGGi hsa:719.

    Organism-specific databases

    CTDi 719.
    PharmGKBi PA25898.

    Phylogenomic databases

    HOVERGENi HBG002433.
    KOi K04009.
    OMAi LWVAGLK.
    PhylomeDBi A8K2H7.

    Miscellaneous databases

    GenomeRNAii 719.
    NextBioi 2926.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 2 hits.
    [Graphical view ]
    PRINTSi PR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Cord bloodImported.
    4. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Caudate nucleusImported.

    Entry informationi

    Entry nameiA8K2H7_HUMAN
    AccessioniPrimary (citable) accession number: A8K2H7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.