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Protein
Submitted name:

Complement component 3a receptor 1, isoform CRA_a

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 3a receptor 1, isoform CRA_aImported
Submitted name:
cDNA FLJ78205, highly similar to Homo sapiens complement component 3a receptor 1, mRNAImported
Submitted name:
cDNA, FLJ92813, Homo sapiens complement component 3a receptor 1 (C3AR1), mRNAImported
Gene namesi
Name:C3AR1Imported
ORF Names:hCG_22220Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000171860.4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 47HelicalSequence analysisAdd BLAST25
Transmembranei59 – 77HelicalSequence analysisAdd BLAST19
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Transmembranei139 – 160HelicalSequence analysisAdd BLAST22
Transmembranei341 – 363HelicalSequence analysisAdd BLAST23
Transmembranei375 – 396HelicalSequence analysisAdd BLAST22
Transmembranei416 – 438HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25898

Expressioni

Gene expression databases

BgeeiENSG00000171860
ExpressionAtlasiA8K2H7 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 435G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST396

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IUVF Eukaryota
ENOG410YBJQ LUCA
HOVERGENiHBG002433
KOiK04009
OMAiTVWFLHL
OrthoDBiEOG091G0AEJ

Family and domain databases

InterProiView protein in InterPro
IPR001644 Anaphtx_C3AR1
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF28 PTHR24225:SF28, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR01104 ANPHYLATOXNR
PR01060 C3ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8K2H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI
210 220 230 240 250
VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT
260 270 280 290 300
SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
310 320 330 340 350
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV
360 370 380 390 400
IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS
410 420 430 440 450
LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI
460 470 480
QGILEAAFSE ELTRSTHCPS NNVISERNST TV
Length:482
Mass (Da):53,864
Last modified:December 4, 2007 - v1
Checksum:i287E219D98CED203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290242 mRNA Translation: BAF82931.1
AK312458 mRNA Translation: BAG35365.1
CH471116 Genomic DNA Translation: EAW88640.1
CH471116 Genomic DNA Translation: EAW88641.1
RefSeqiNP_001313404.1, NM_001326475.1
NP_001313406.1, NM_001326477.1
NP_004045.1, NM_004054.3
UniGeneiHs.504656
Hs.591148

Genome annotation databases

GeneIDi719
KEGGihsa:719

Similar proteinsi

Entry informationi

Entry nameiA8K2H7_HUMAN
AccessioniPrimary (citable) accession number: A8K2H7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health