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Protein
Submitted name:

cDNA FLJ76704, highly similar to Homo sapiens leukemia inhibitory factor receptor (LIFR), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ76704, highly similar to Homo sapiens leukemia inhibitory factor receptor (LIFR), mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei834 – 85926HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30371.

PTM / Processingi

Proteomic databases

PaxDbiA8K1Z4.
PeptideAtlasiA8K1Z4.

Expressioni

Gene expression databases

GenevisibleiA8K1Z4. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263409.

Structurei

3D structure databases

ProteinModelPortaliA8K1Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13890Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini335 – 434100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini435 – 534100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini538 – 62992Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini724 – 833110Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
HOVERGENiHBG006266.
KOiK05058.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K1Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP
60 70 80 90 100
HDLKCVTNNL QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI
110 120 130 140 150
PALSHGDYEI TINSLHDFGS STSKFTLNEQ NVSLIPDTPE ILNLSADFST
160 170 180 190 200
STLYLKWNDR GSVFPHRSNV IWEIKVLRKE SMELVKLVTH NTTLNGKDTL
210 220 230 240 250
HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP VRNISWIPDS
260 270 280 290 300
QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK
310 320 330 340 350
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII
360 370 380 390 400
CSWNPGRVTA LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML
410 420 430 440 450
PNQEIYNFTL NAHNPLGRSQ STILVNITEK VYPHTPTSFK VKDINSTAVK
460 470 480 490 500
LSWHLPGNFA KINFLCEIEI KKSNSVQEQR NVTIKGVENS SYLVALDKLN
510 520 530 540 550
PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD TWREWSSDGK
560 570 580 590 600
NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK
610 620 630 640 650
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD
660 670 680 690 700
PNMTCDYVIK WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF
710 720 730 740 750
LYGCRNQGYQ LLRSMIGYIE ELAPIVAPNF TVEDTSADSI LVKWEDIPVE
760 770 780 790 800
ELRGFLRGYL FYFGKGERDT SKMRVLESGR SDIKVKNITD ISQKTLRIAD
810 820 830 840 850
LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI LIPVAVAVIV
860 870 880 890 900
GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM
910 920 930 940 950
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC
960 970 980 990 1000
PPIIEEEIPN PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG
1010 1020 1030 1040 1050
YKPQMHLPIN STVEDIAAEE DLDKTAGYRP QANVNTWNLV SPDSPRSIDS
1060 1070 1080 1090
NSEIVSFGSP CSINSRQFLI PPKDEDFPKS NGGGWSFTNF FQNKPND
Length:1,097
Mass (Da):123,831
Last modified:December 4, 2007 - v1
Checksum:i5E600CB2EE929FF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290059 mRNA. Translation: BAF82748.1.
RefSeqiNP_001121143.1. NM_001127671.1.
UniGeneiHs.133421.

Genome annotation databases

GeneIDi3977.
KEGGihsa:3977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290059 mRNA. Translation: BAF82748.1.
RefSeqiNP_001121143.1. NM_001127671.1.
UniGeneiHs.133421.

3D structure databases

ProteinModelPortaliA8K1Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263409.

Proteomic databases

PaxDbiA8K1Z4.
PeptideAtlasiA8K1Z4.

Protocols and materials databases

DNASUi3977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3977.
KEGGihsa:3977.

Organism-specific databases

CTDi3977.
PharmGKBiPA30371.

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
HOVERGENiHBG006266.
KOiK05058.

Miscellaneous databases

GenomeRNAii3977.

Gene expression databases

GenevisibleiA8K1Z4. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiA8K1Z4_HUMAN
AccessioniPrimary (citable) accession number: A8K1Z4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.