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Protein
Submitted name:

G protein-coupled receptor 63

Gene

GPR63

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
G protein-coupled receptor 63Imported
Submitted name:
cDNA FLJ78200, highly similar to Homo sapiens PSP24Imported
Submitted name:
cDNA, FLJ94093, Homo sapiens G protein-coupled receptor 63 (GPR63), mRNAImported
Gene namesi
Name:GPR63Imported
ORF Names:hCG_1646313Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 107HelicalSequence analysisAdd BLAST26
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei159 – 177HelicalSequence analysisAdd BLAST19
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei241 – 266HelicalSequence analysisAdd BLAST26
Transmembranei312 – 335HelicalSequence analysisAdd BLAST24
Transmembranei355 – 373HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28907.

Expressioni

Gene expression databases

BgeeiENSG00000112218.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229955.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 371G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST274

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG051812.
KOiK04321.
OMAiYYWRIKK.
OrthoDBiEOG091G07RP.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8K1C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET
60 70 80 90 100
MAPTGLSSLT VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL
110 120 130 140 150
VVCLMVYQKA AMRSAINILL ASLAFADMLL AVLNMPFALV TILTTRWIFG
160 170 180 190 200
KFFCRVSAMF FWLFVIEGVA ILLIISIDRF LIIVQRQDKL NPYRAKVLIA
210 220 230 240 250
VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ AYVILISLIS
260 270 280 290 300
FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF
310 320 330 340 350
QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF
360 370 380 390 400
EISTWLLWLC YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT
410
KRRIRPSAVY VCGEHRTVV
Length:419
Mass (Da):47,578
Last modified:December 4, 2007 - v1
Checksum:i17418CD0AE1D6C8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ348260 mRNA. Translation: ACI96304.1.
AK289839 mRNA. Translation: BAF82528.1.
AK313535 mRNA. Translation: BAG36312.1.
CH471051 Genomic DNA. Translation: EAW48502.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715633.1. XM_006715570.3.
XP_011534455.1. XM_011536153.2.
XP_011534456.1. XM_011536154.2.
XP_011534457.1. XM_011536155.2.
XP_011534459.1. XM_011536157.2.
XP_011534461.1. XM_011536159.2.
XP_016866823.1. XM_017011334.1.
UniGeneiHs.221364.

Genome annotation databases

GeneIDi81491.
KEGGihsa:81491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ348260 mRNA. Translation: ACI96304.1.
AK289839 mRNA. Translation: BAF82528.1.
AK313535 mRNA. Translation: BAG36312.1.
CH471051 Genomic DNA. Translation: EAW48502.1.
RefSeqiNP_001137429.1. NM_001143957.2.
NP_110411.1. NM_030784.3.
XP_006715633.1. XM_006715570.3.
XP_011534455.1. XM_011536153.2.
XP_011534456.1. XM_011536154.2.
XP_011534457.1. XM_011536155.2.
XP_011534459.1. XM_011536157.2.
XP_011534461.1. XM_011536159.2.
XP_016866823.1. XM_017011334.1.
UniGeneiHs.221364.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000229955.

Protocols and materials databases

DNASUi81491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81491.
KEGGihsa:81491.

Organism-specific databases

CTDi81491.
PharmGKBiPA28907.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG051812.
KOiK04321.
OMAiYYWRIKK.
OrthoDBiEOG091G07RP.

Miscellaneous databases

GenomeRNAii81491.

Gene expression databases

BgeeiENSG00000112218.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8K1C4_HUMAN
AccessioniPrimary (citable) accession number: A8K1C4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.