cDNA FLJ75537, highly similar to Homo sapiens sodium channel, voltage-gated, type II, alpha 2 (SCN2A2), mRNA

Functionⁱ

GO - Molecular functionⁱ

ion channel activity Source: InterPro

Keywordsⁱ

Molecular function	Ion channelImported
Biological process	Ion transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cDNA FLJ75537, highly similar to Homo sapiens sodium channel, voltage-gated, type II, alpha 2 (SCN2A2), mRNAImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	125 – 148	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	251 – 271	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	401 – 428	HelicalSequence analysisAdd BLAST	28

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	A8K0U1.
PeptideAtlas More...PeptideAtlasⁱ	A8K0U1.
PRIDEⁱ	A8K0U1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136531.

Bgeeⁱ

ENSG00000136531.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000283256.

STRINGⁱ

9606.ENSP00000283256.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A8K0U1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	128 – 435	Ion_transInterPro annotationAdd BLAST		308

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	425 – 470	Sequence analysisAdd BLAST		46

Keywords - Domainⁱ

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410INF8. Eukaryota. COG1226. LUCA.
HOGENOMⁱ	HOG000199493.
HOVERGENⁱ	HBG091796.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005821. Ion_trans_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00520. Ion_trans. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

A8K0U1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP 
        60         70         80         90        100
KPNSDLEAGK SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI 
       110        120        130        140        150
SRFSATPALY ILTPFNPIRK LAIKILVHSL FNMLIMCTIL TNCVFMTMSN 
       160        170        180        190        200
PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRDP WNWLDFTVIT 
       210        220        230        240        250
FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD 
       260        270        280        290        300
VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITSFFNNSL 
       310        320        330        340        350
DGNGTTFNRT VSIFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG 
       360        370        380        390        400
YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT 
       410        420        430        440        450
YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML 
       460        470        480        490        500
EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE 

LKN

Length:503

Mass (Da):56,745

Last modified:December 4, 2007 - v1

Checksum:ⁱ4A2BD0F25209FF4A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	503	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289656 mRNA. Translation: BAF82345.1.
UniGeneⁱ	Hs.93485.

Genome annotation databases

UCSC genome browser More...UCSCⁱ	uc061pdn.1. human.

UCSCⁱ

uc061pdn.1. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289656 mRNA. Translation: BAF82345.1.
UniGeneⁱ	Hs.93485.

3D structure databases

ProteinModelPortalⁱ	A8K0U1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000283256.

STRINGⁱ

9606.ENSP00000283256.

Proteomic databases

PaxDbⁱ	A8K0U1.
PeptideAtlas More...PeptideAtlasⁱ	A8K0U1.
PRIDEⁱ	A8K0U1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSC genome browser More...UCSCⁱ	uc061pdn.1. human.

UCSCⁱ

uc061pdn.1. human.

Phylogenomic databases

eggNOGⁱ	ENOG410INF8. Eukaryota. COG1226. LUCA.
HOGENOMⁱ	HOG000199493.
HOVERGENⁱ	HBG091796.

Miscellaneous databases

ChiTaRSⁱ	SCN2A. human.

ChiTaRSⁱ

SCN2A. human.

Gene expression databases

Bgeeⁱ	ENSG00000136531.

Bgeeⁱ

ENSG00000136531.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005821. Ion_trans_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00520. Ion_trans. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8K0U1_HUMAN
Accessionⁱ	A8K0U1Primary (citable) accession number: A8K0U1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 4, 2007
	Last sequence update:	December 4, 2007
	Last modified:	April 12, 2017
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A8K0U1 (A8K0U1_HUMAN)

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cDNA FLJ75537, highly similar to Homo sapiens sodium channel, voltage-gated, type II, alpha 2 (SCN2A2), mRNA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ