UniProtKB - A8K0U1 (A8K0U1_HUMAN)
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Protein
Submitted name:
cDNA FLJ75537, highly similar to Homo sapiens sodium channel, voltage-gated, type II, alpha 2 (SCN2A2), mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ion channel activity Source: InterPro
Keywordsi
Molecular function | Ion channelImported |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ75537, highly similar to Homo sapiens sodium channel, voltage-gated, type II, alpha 2 (SCN2A2), mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 125 – 148 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 251 – 271 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 428 | HelicalSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 128 – 435 | Ion_transInterPro annotationAdd BLAST | 308 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 22 – 42 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 425 – 470 | Sequence analysisAdd BLAST | 46 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | ENOG410INF8. Eukaryota. COG1226. LUCA. |
HOGENOMi | HOG000199493. |
HOVERGENi | HBG091796. |
Family and domain databases
Gene3Di | 1.20.120.350. 1 hit. |
InterProi | View protein in InterPro IPR005821. Ion_trans_dom. IPR027359. Volt_channel_dom_sf. |
Pfami | View protein in Pfam PF00520. Ion_trans. 1 hit. |
i Sequence
Sequence statusi: Fragment.
A8K0U1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP
60 70 80 90 100
KPNSDLEAGK SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI
110 120 130 140 150
SRFSATPALY ILTPFNPIRK LAIKILVHSL FNMLIMCTIL TNCVFMTMSN
160 170 180 190 200
PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRDP WNWLDFTVIT
210 220 230 240 250
FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITSFFNNSL
310 320 330 340 350
DGNGTTFNRT VSIFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG
360 370 380 390 400
YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT
410 420 430 440 450
YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML
460 470 480 490 500
EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE
LKN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 503 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289656 mRNA. Translation: BAF82345.1. |
UniGenei | Hs.93485. |
Genome annotation databases
UCSCi | uc061pdn.1. human. |
Similar proteinsi
Entry informationi
Entry namei | A8K0U1_HUMAN | |
Accessioni | A8K0U1Primary (citable) accession number: A8K0U1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 28, 2018 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |