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Protein

Zinc finger protein 839

Gene

ZNF839

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22226C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 839
Alternative name(s):
Renal carcinoma antigen NY-REN-50
Gene namesi
Name:ZNF839
Synonyms:C14orf131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20345. ZNF839.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410800.

Polymorphism and mutation databases

BioMutaiZNF839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Zinc finger protein 839PRO_0000328721Add
BLAST

Proteomic databases

MaxQBiA8K0R7.
PaxDbiA8K0R7.
PRIDEiA8K0R7.

PTM databases

iPTMnetiA8K0R7.
PhosphoSiteiA8K0R7.

Expressioni

Gene expression databases

BgeeiENSG00000022976.
CleanExiHS_ZNF839.
ExpressionAtlasiA8K0R7. baseline and differential.
GenevisibleiA8K0R7. HS.

Organism-specific databases

HPAiHPA020434.

Interactioni

Protein-protein interaction databases

BioGridi120893. 3 interactions.
IntActiA8K0R7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA8K0R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 1086Poly-Ser

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22226C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFJC. Eukaryota.
ENOG4111JK5. LUCA.
GeneTreeiENSGT00390000002751.
HOVERGENiHBG108776.
InParanoidiA8K0R7.
OMAiCQDYLSG.
OrthoDBiEOG091G0A2R.
PhylomeDBiA8K0R7.
TreeFamiTF328610.

Family and domain databases

InterProiIPR031885. DUF4764.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF15961. DUF4764. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8K0R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPTTIQPQ TARKSQLPRG NSCLVGLHIA SPQLLRVQPL VRTEPQSCFL
60 70 80 90 100
SDLCQPPAQG FVQRPLPALQ VVPAKRVPAP KAPDEQGSML TPLSASDPLA
110 120 130 140 150
VTSLSSSSAH PFISNLHTRH TEKLKKSLKV KTRSGRVSRP PKYKAKDYKF
160 170 180 190 200
IKTEDLADGH LSDSDDYSEL CVEEDEDQRE RHALFDLSSC SLRPKSFKCQ
210 220 230 240 250
TCEKSYIGKG GLARHFKLNP GHGQLDPEMV LSEKASGSTL RGCTEERTLS
260 270 280 290 300
LTSLGLSMPA DPCEGGARSC LVTESARGGL QNGQSVDVEE TLPSEPENGA
310 320 330 340 350
LLRSERYQGP RRRACSETLA ESRTAVLQQR RAAQLPGGPA AAGEQRASPS
360 370 380 390 400
KARLKEFLQQ CDREDLVELA LPQLAQVVTV YEFLLMKVEK DHLAKPFFPA
410 420 430 440 450
IYKEFEELHK MVKKMCQDYL SSSGLCSQET LEINNDKVAE SLGITEFLRK
460 470 480 490 500
KEIHPDNLGP KHLSRDMDGE QLEGASSEKR EREAAEEGLA SVKRPRREAL
510 520 530 540 550
SNDTTESLAA NSRGREKPRP LHALAAGFSP PVNVTVSPRS EESHTTTVSG
560 570 580 590 600
GNGSVFQAGP QLQALANLEA RRGSIGAALS SRDVSGLPVY AQSGEPRRLT
610 620 630 640 650
QAQVAAFPGE NALEHSSDQD TWDSLRSPGF CSPLSSGGGA ESLPPGGPGH
660 670 680 690 700
AEAGHLGKVC DFHLNHQQPS PTSVLPTEVA APPLEKILSV DSVAVDCAYR
710 720 730 740 750
TVPKPGPQPG PHGSLLTEGC LRSLSGDLNR FPCGMEVHSG QRELESVVAV
760 770 780 790 800
GEAMAFEISN GSHELLSQGQ KQIFIQTSDG LILSPPGTIV SQEEDIVTVT
810
DAEGRACGWA R
Length:811
Mass (Da):87,484
Last modified:December 4, 2007 - v1
Checksum:i58E2C46E98154976
GO
Isoform 2 (identifier: A8K0R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-527: G → GEG

Note: No experimental confirmation available.
Show »
Length:813
Mass (Da):87,670
Checksum:iADE65A604CA4AC52
GO
Isoform 3 (identifier: A8K0R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADAEPEAGG...GETKGQERPM

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):99,444
Checksum:iEDEACFA77ADFE155
GO

Sequence cautioni

The sequence BAA92026 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD62594 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4111M → L in AAH73137 (PubMed:15489334).Curated
Sequence conflicti418 – 4181D → G in BAD97032 (Ref. 5) Curated
Sequence conflicti479 – 4791K → E in BAG52694 (PubMed:14702039).Curated
Sequence conflicti590 – 5901Y → C in BAA92026 (PubMed:14702039).Curated
Sequence conflicti771 – 7711K → R in BAD97032 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti314 – 3141A → T.
Corresponds to variant rs1543540 [ dbSNP | Ensembl ].
VAR_057456
Natural varianti531 – 5311P → S.
Corresponds to variant rs9464 [ dbSNP | Ensembl ].
VAR_042468
Natural varianti693 – 6931V → M.
Corresponds to variant rs28646161 [ dbSNP | Ensembl ].
VAR_042469
Natural varianti731 – 7311F → L.
Corresponds to variant rs1053019 [ dbSNP | Ensembl ].
VAR_042470

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MADAEPEAGGGSEDGGGGGG PAPPGQSGSVARVAPLGPEQ LRQVLEQVTKAQPPPPPPPF VLRDAARRLRDAAQQAALQR GRGTEPPRLPRLLPPQQLEA ICVKVTSGETKGQERPM in isoform 3. 1 PublicationVSP_040648
Alternative sequencei527 – 5271G → GEG in isoform 2. 1 PublicationVSP_032760

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001994 mRNA. Translation: BAA92026.1. Different initiation.
AK289632 mRNA. Translation: BAF82321.1.
AK093342 mRNA. Translation: BAG52694.1.
AL137229 Genomic DNA. No translation available.
AL352978 Genomic DNA. No translation available.
BX248266 mRNA. Translation: CAD62594.1. Different initiation.
BC073137 mRNA. Translation: AAH73137.2.
AK223312 mRNA. Translation: BAD97032.1.
CCDSiCCDS45164.1. [A8K0R7-5]
CCDS58336.1. [A8K0R7-1]
RefSeqiNP_001254756.1. NM_001267827.1. [A8K0R7-1]
NP_001254757.1. NM_001267828.1. [A8K0R7-1]
NP_060805.3. NM_018335.4. [A8K0R7-5]
XP_006720266.2. XM_006720203.3. [A8K0R7-1]
XP_011535250.1. XM_011536948.2. [A8K0R7-1]
UniGeneiHs.743359.

Genome annotation databases

EnsembliENST00000442396; ENSP00000399863; ENSG00000022976. [A8K0R7-5]
ENST00000558850; ENSP00000453363; ENSG00000022976. [A8K0R7-1]
ENST00000559185; ENSP00000453109; ENSG00000022976. [A8K0R7-1]
GeneIDi55778.
KEGGihsa:55778.
UCSCiuc001ylo.4. human. [A8K0R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001994 mRNA. Translation: BAA92026.1. Different initiation.
AK289632 mRNA. Translation: BAF82321.1.
AK093342 mRNA. Translation: BAG52694.1.
AL137229 Genomic DNA. No translation available.
AL352978 Genomic DNA. No translation available.
BX248266 mRNA. Translation: CAD62594.1. Different initiation.
BC073137 mRNA. Translation: AAH73137.2.
AK223312 mRNA. Translation: BAD97032.1.
CCDSiCCDS45164.1. [A8K0R7-5]
CCDS58336.1. [A8K0R7-1]
RefSeqiNP_001254756.1. NM_001267827.1. [A8K0R7-1]
NP_001254757.1. NM_001267828.1. [A8K0R7-1]
NP_060805.3. NM_018335.4. [A8K0R7-5]
XP_006720266.2. XM_006720203.3. [A8K0R7-1]
XP_011535250.1. XM_011536948.2. [A8K0R7-1]
UniGeneiHs.743359.

3D structure databases

ProteinModelPortaliA8K0R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120893. 3 interactions.
IntActiA8K0R7. 2 interactions.

PTM databases

iPTMnetiA8K0R7.
PhosphoSiteiA8K0R7.

Polymorphism and mutation databases

BioMutaiZNF839.

Proteomic databases

MaxQBiA8K0R7.
PaxDbiA8K0R7.
PRIDEiA8K0R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442396; ENSP00000399863; ENSG00000022976. [A8K0R7-5]
ENST00000558850; ENSP00000453363; ENSG00000022976. [A8K0R7-1]
ENST00000559185; ENSP00000453109; ENSG00000022976. [A8K0R7-1]
GeneIDi55778.
KEGGihsa:55778.
UCSCiuc001ylo.4. human. [A8K0R7-1]

Organism-specific databases

CTDi55778.
GeneCardsiZNF839.
HGNCiHGNC:20345. ZNF839.
HPAiHPA020434.
neXtProtiNX_A8K0R7.
PharmGKBiPA162410800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJC. Eukaryota.
ENOG4111JK5. LUCA.
GeneTreeiENSGT00390000002751.
HOVERGENiHBG108776.
InParanoidiA8K0R7.
OMAiCQDYLSG.
OrthoDBiEOG091G0A2R.
PhylomeDBiA8K0R7.
TreeFamiTF328610.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55778.
PROiA8K0R7.

Gene expression databases

BgeeiENSG00000022976.
CleanExiHS_ZNF839.
ExpressionAtlasiA8K0R7. baseline and differential.
GenevisibleiA8K0R7. HS.

Family and domain databases

InterProiIPR031885. DUF4764.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF15961. DUF4764. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN839_HUMAN
AccessioniPrimary (citable) accession number: A8K0R7
Secondary accession number(s): B3KSD2
, Q53FH5, Q6GPI5, Q86TU1, Q9BQ86, Q9NUU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.