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Protein
Submitted name:

Kinetochore associated 2, isoform CRA_a

Gene

KNTC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Kinetochore associated 2, isoform CRA_aImported
Submitted name:
NDC80 homolog, kinetochore complex component (S. cerevisiae)Imported
Submitted name:
cDNA FLJ77925, highly similar to Homo sapiens kinetochore associated 2, mRNAImported
Submitted name:
cDNA, FLJ93683, Homo sapiens kinetochore associated 2 (KNTC2), mRNAImported
Gene namesi
Name:KNTC2Imported
Synonyms:NDC80Imported
ORF Names:hCG_38410Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000080986.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397359

PTM / Processingi

Proteomic databases

PRIDEiA8K031

Expressioni

Gene expression databases

BgeeiENSG00000080986
ExpressionAtlasiA8K031 baseline and differential

Structurei

3D structure databases

SMRiA8K031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili265 – 299Sequence analysisAdd BLAST35
Coiled coili314 – 355Sequence analysisAdd BLAST42
Coiled coili366 – 400Sequence analysisAdd BLAST35
Coiled coili458 – 538Sequence analysisAdd BLAST81
Coiled coili550 – 570Sequence analysisAdd BLAST21
Coiled coili597 – 617Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0995 Eukaryota
COG5185 LUCA
HOVERGENiHBG081861
KOiK11547
OMAiKSPTQKD
OrthoDBiEOG091G046M

Family and domain databases

Gene3Di1.10.418.30, 1 hit
InterProiView protein in InterPro
IPR005550 Kinetochore_Ndc80
IPR038273 Ndc80_sf
PANTHERiPTHR10643 PTHR10643, 1 hit
PfamiView protein in Pfam
PF03801 Ndc80_HEC, 1 hit

Sequencei

Sequence statusi: Complete.

A8K031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSSVSSGG AGRLSMQELR SQDVNKQGLY TPQTKEKPTF GKLSINKPTS
60 70 80 90 100
ERKVSLFGKR TSGHGSRNSQ LGIFSSSEKI KDPRPLNDKA FIQQCIRQLC
110 120 130 140 150
EFLTENGYAH NVSMKSLQAP SVKDFLKIFT FLYGFLCPSY ELPDTKFEEE
160 170 180 190 200
VPRIFKDLGY PFALSKSSMY TVGAPHTWPH IVAALVWLID CIKIHTAMKE
210 220 230 240 250
SSPLFDDGQP WGEETEDGIM HNKLFLDYTI KCYESFMSGA DSFDEMNAEL
260 270 280 290 300
QSKLKDLFNV DAFKLESLEA KNRALNEQIA RLEQEREKEP NRLESLRKLK
310 320 330 340 350
ASLQGDVQKY QAYMSNLESH SAILDQKLNG LNEEIARVEL ECETIKQENT
360 370 380 390 400
RLQNIIDNQK YSVADIERIN HERNELQQTI NKLTKDLEAE QQKLWNEELK
410 420 430 440 450
YARGKEAIET QLAEYHKLAR KLKLIPKGAE NSKGYDFEIK FNPEAGANCL
460 470 480 490 500
VKYRAQVYVP LKELLNETEE EINKALNKKM GLEDTLEQLN AMITESKRSV
510 520 530 540 550
RTLKEEVQKL DDLYQQKIKE AEEEDEKCAS ELESLEKHKH LLESTVNQGL
560 570 580 590 600
SEAMNELDAV QREYQLVVQT TTEERRKVGN NLQRLLEMVA THVGSVEKHL
610 620 630 640
EEQIAKVDRE YEECMSEDLS ENIKEIRDKY EKKATLIKSS EE
Length:642
Mass (Da):73,913
Last modified:December 4, 2007 - v1
Checksum:i6A82DA4D8B77ECDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035617 mRNA Translation: AAH35617.1
AK289396 mRNA Translation: BAF82085.1
AK313184 mRNA Translation: BAG36001.1
CH471113 Genomic DNA Translation: EAX01696.1
CH471113 Genomic DNA Translation: EAX01697.1
RefSeqiNP_006092.1, NM_006101.2
UniGeneiHs.414407

Genome annotation databases

GeneIDi10403
KEGGihsa:10403

Similar proteinsi

Entry informationi

Entry nameiA8K031_HUMAN
AccessioniPrimary (citable) accession number: A8K031
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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