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Protein
Submitted name:

Cholecystokinin-like receptor at 17D1

Gene

CCKLR-17D1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • G-protein coupled receptor activity Source: FlyBase
  • neuropeptide receptor activity Source: FlyBase

GO - Biological processi

  • adult locomotory behavior Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • larval locomotory behavior Source: FlyBase
  • multicellular organismal response to stress Source: FlyBase
  • neuromuscular junction development Source: FlyBase
  • neuropeptide signaling pathway Source: FlyBase
  • positive regulation of cytosolic calcium ion concentration Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Cholecystokinin-like receptor at 17D1Imported
Gene namesi
Name:CCKLR-17D1Imported
ORF Names:CG42301Imported, Dmel_CG42301Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259231. CCKLR-17D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei174 – 201HelicalSequence analysisAdd BLAST28
Transmembranei213 – 238HelicalSequence analysisAdd BLAST26
Transmembranei250 – 275HelicalSequence analysisAdd BLAST26
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Transmembranei344 – 365HelicalSequence analysisAdd BLAST22
Transmembranei548 – 569HelicalSequence analysisAdd BLAST22
Transmembranei589 – 610HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • neuronal cell body Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA8JUP8.

Expressioni

Gene expression databases

BgeeiFBgn0259231.
GenevisibleiA8JUP8. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0288959.

Structurei

3D structure databases

ProteinModelPortaliA8JUP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 607G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST416

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
InParanoidiA8JUP8.
KOiK04196.
OMAiGSHEISN.
OrthoDBiEOG091G0PAV.
PhylomeDBiA8JUP8.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8JUP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLCADAC RQCFAKIARR DTHRGTRTPY GCADTQSRPK PNFLLREVDE
60 70 80 90 100
VCCTAASASP RLLVLFRDHK RASFFGLTID AFYHYLRQAL PLAKEAAIHL
110 120 130 140 150
NASNEISAVG DGVTITGTPG DLLNYSGLEL DLGLDLDLNL DMDLATTPSS
160 170 180 190 200
STLAPAVTVR TPGNRSVVRV SADVPIWVVP CYSAILLCAV VGNLLVVLTL
210 220 230 240 250
VQNRRMRTIT NVFLLNLAIS DILLGVFCMP VTLVGTLLRH FIFGELLCKL
260 270 280 290 300
IQFAQAASVA VSSWTLVAIS CERYYAICHP LRSRTWQTIN HANKIIAIIW
310 320 330 340 350
LGSLVCMTPI AAFSQLMPTS RPGLRKCREQ WPADSLNYER AYNLFLDLAL
360 370 380 390 400
LVLPLLALSF TYLFITRTLY VSMRNERAMN FGSSGPEVTT SSSAAVAEAG
410 420 430 440 450
SQRRANGSHC QSLDTIVPHQ HNPHQQHHHH SQYYYDYGHC GSKRRLISGG
460 470 480 490 500
GPCEGRRHLY CMRSASVKSL RHQQINGGGG TLSGTGAGNG ECCSRVHRMR
510 520 530 540 550
QQMQLQQQGY VSDNESRRKS LSQPSLRITE AGLRRSNETK SLESKKRVVK
560 570 580 590 600
MLFVLVLEFF ICWTPLYVIN TMTMLLGPTV YEYVGYTSIS FLQLLAYSSS
610 620 630 640 650
CCNPITYCFM NASFRRAFVD TFKGMRVCER LCAPCCFWRR RSKNETNLSV
660 670
AGNSIALANS VMSSHTILES PRL
Length:673
Mass (Da):74,859
Last modified:December 4, 2007 - v1
Checksum:i951BCA97A93D8F03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: ABW09450.1.
RefSeqiNP_001097021.1. NM_001103551.2.
UniGeneiDm.22833.

Genome annotation databases

EnsemblMetazoaiFBtr0299681; FBpp0288959; FBgn0259231.
GeneIDi32860.
KEGGidme:Dmel_CG42301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: ABW09450.1.
RefSeqiNP_001097021.1. NM_001103551.2.
UniGeneiDm.22833.

3D structure databases

ProteinModelPortaliA8JUP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0288959.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiA8JUP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299681; FBpp0288959; FBgn0259231.
GeneIDi32860.
KEGGidme:Dmel_CG42301.

Organism-specific databases

CTDi32860.
FlyBaseiFBgn0259231. CCKLR-17D1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
InParanoidiA8JUP8.
KOiK04196.
OMAiGSHEISN.
OrthoDBiEOG091G0PAV.
PhylomeDBiA8JUP8.

Miscellaneous databases

ChiTaRSiCCKLR-17D1. fly.
GenomeRNAii32860.

Gene expression databases

BgeeiFBgn0259231.
GenevisibleiA8JUP8. DM.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8JUP8_DROME
AccessioniPrimary (citable) accession number: A8JUP8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.