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A8JQ65

- DGKH_DROME

UniProt

A8JQ65 - DGKH_DROME

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Protein

Diacylglycerol kinase eta

Gene

CG34384

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 31852Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. phosphorylation Source: FlyBase
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  4. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:CG34384
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0085413. CG34384.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18951895Diacylglycerol kinase etaPRO_0000375987Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA8JQ65.

Expressioni

Gene expression databases

BgeeiA8JQ65.

Interactioni

Protein-protein interaction databases

BioGridi624993. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8JQ65.
SMRiA8JQ65. Positions 81-178, 196-245, 248-323, 1832-1893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini349 – 485137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1832 – 189564SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 31852Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
GeneTreeiENSGT00760000119050.
InParanoidiA8JQ65.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8JQ65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD
60 70 80 90 100
GDESESESEI ETEPARLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGIIMPHQW MEGNLPVSSM CAVCKKTCGS VLRLQDWRCL
310 320 330 340 350
WCRATVHVAC RPQMAVACPI GPAKLSVVPP TSVHSISTDD AWDVASPKGN
360 370 380 390 400
FSPLLVFVNS KSGDNQGVKF LRRFKQLLNP AQVFDLISTG PSLGLRLFRH
410 420 430 440 450
FEMFRILVCS GDGSVGWVLS EIDRFNMHKQ CQVAVMPLGT GNDLARVLGW
460 470 480 490 500
GSSCDDDTHL PQILERYESA STKMLDRWSI MVFEKAIPVP KTPKMSISTE
510 520 530 540 550
QEAMLTGMVT SANHHLRFIV ETNDTQTLIR STRNLCDTVD DLVCRISEHH
560 570 580 590 600
KDDEQLAVKC DILRQKLNML LDALQEEEIG AHSGDDLIAT IRSLIARSIP
610 620 630 640 650
VTPGSNAYLL NPNISIEKTE KDQINTKERR NSRSLRSSEK EALQCRANSV
660 670 680 690 700
KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKLPTASGES TPCTSPLPII
710 720 730 740 750
PPINIISPTM ETSRLTCISP LPDTRRDSVD ENFFNSINLP APRQFADSRR
760 770 780 790 800
SSGVEVIQEI EEGANGETVY RKSRMSLTGG ANIDDAGNRL SPCSDAGENT
810 820 830 840 850
PTERKVDFLR VPIHTGEPIV DPLCDYRPHE VFERTYYMTR EMDKGKEKDK
860 870 880 890 900
EKDKPVEIDK EKDTCVEKEG SMPAEKLVHT CNLQVPGVVV TPNPQNVYSS
910 920 930 940 950
ASITIIDTDA QTTTEQSSSD DLGGEASDVL SAISNEECSV ASEIFDKQDA
960 970 980 990 1000
GQTVGDIIQN MDASNFTHID SPETSDETEA MPGESIMDDI SSVLGHDITY
1010 1020 1030 1040 1050
ALQDNTLTDD TTTLCSEHAG PPKPPRKKSL SALSRTQAHP RRRNSSPPRM
1060 1070 1080 1090 1100
ARLARMDSDD NPQQFGFENI VFEIDNRCDD QKMREPPRYC SLAQFVEGND
1110 1120 1130 1140 1150
IARQSFKQLM LEQHRGGDND SDYPEHEQTP TNKGANLLAT TSEDELSTQT
1160 1170 1180 1190 1200
AIKIEIQDID ATVRNLNSSM KPNTILTTST SPTKKSGHGQ DVKRITFDES
1210 1220 1230 1240 1250
CKKESFDDVN PNYPQISVVV RPPTPLRGDC IKPTVSLLPV SSGGAMTVSM
1260 1270 1280 1290 1300
TCSGMLGVRA MNASEIRRHS SHAPGLAVRE FDKDKDRRHS GFNPNQLTLD
1310 1320 1330 1340 1350
PEHARFLSSS PAASRRISCG SLFKPNEALP NLQTLKGSKS SLFMGSTLFG
1360 1370 1380 1390 1400
FDHLASAEKD KEEKSGKDKE KTPTDETNRK LPIINPLVRL PNWPNLANGG
1410 1420 1430 1440 1450
GFISKCLLAN ADTLCAAVSP LMDPDETLLA GYHEKCVMNN YFGIGIDAKI
1460 1470 1480 1490 1500
SLDFHNKREE HPEKCRSRAR NYMWYGVLGS KQLLQKTCKN LEQRVQLECD
1510 1520 1530 1540 1550
GQRIPLPELQ GIVILNIPSF MGGTNFWGSS KKDDIFLPPS FDDRVLEVVA
1560 1570 1580 1590 1600
VFGSVQMAAS RLINLQHHRI AQCQSVQINI LGDEEIPIQV DGEAWLQPPG
1610 1620 1630 1640 1650
MIRILHKNRV QMLCRNRSLE LSLKSWQEKQ RQHSISIQRD ASSTASEHAN
1660 1670 1680 1690 1700
STDEVISERE CYVLLNFIEA VSSLVKWVKF LIISHPALQH DLYEVACRAS
1710 1720 1730 1740 1750
EALESIHPQG KLLEGPSLRT KLVEVIDSSR QLYDDACTLL RDRGHSLILR
1760 1770 1780 1790 1800
EDLETKLSAA LANMEMELKK CSVQKCIDGK LRAYFNVLAP NEESDGRRKS
1810 1820 1830 1840 1850
RPFWVRLRSG STAGQQAFKP PLTNTREAAN NWSVNEVVTW LETMQLSEYV
1860 1870 1880 1890
DSFLKNDIRG KELLTLGRRD LKDLGVVKVG HVKRILQAIK DLSEN
Length:1,895
Mass (Da):211,659
Last modified:December 4, 2007 - v1
Checksum:iC152645B61070314
GO

Sequence cautioni

The sequence AAO39647.1 differs from that shown. Reason: Frameshift and deletion of residues 1685-1699.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1192 – 121524Missing in AAO39647. 1 PublicationCuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: ABW08617.1.
BT003643 mRNA. Translation: AAO39647.1. Sequence problems.
RefSeqiNP_001097704.1. NM_001104234.4.
UniGeneiDm.17099.

Genome annotation databases

EnsemblMetazoaiFBtr0112625; FBpp0111537; FBgn0085413.
GeneIDi5740362.
KEGGidme:Dmel_CG34384.
UCSCiCG34384-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: ABW08617.1 .
BT003643 mRNA. Translation: AAO39647.1 . Sequence problems.
RefSeqi NP_001097704.1. NM_001104234.4.
UniGenei Dm.17099.

3D structure databases

ProteinModelPortali A8JQ65.
SMRi A8JQ65. Positions 81-178, 196-245, 248-323, 1832-1893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 624993. 1 interaction.

Proteomic databases

PaxDbi A8JQ65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0112625 ; FBpp0111537 ; FBgn0085413 .
GeneIDi 5740362.
KEGGi dme:Dmel_CG34384.
UCSCi CG34384-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0085413. CG34384.

Phylogenomic databases

eggNOGi NOG328046.
GeneTreei ENSGT00760000119050.
InParanoidi A8JQ65.
KOi K00901.
OrthoDBi EOG7DVD9B.

Miscellaneous databases

GenomeRNAii 5740362.
NextBioi 20891401.
PROi A8JQ65.

Gene expression databases

Bgeei A8JQ65.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1080-1895.
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiDGKH_DROME
AccessioniPrimary (citable) accession number: A8JQ65
Secondary accession number(s): Q86NT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3