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A8JQ65

- DGKH_DROME

UniProt

A8JQ65 - DGKH_DROME

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Protein
Diacylglycerol kinase eta
Gene
CG34384
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri267 – 31852Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. phosphorylation Source: FlyBase
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  4. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:CG34384
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0085413. CG34384.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18951895Diacylglycerol kinase eta
PRO_0000375987Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA8JQ65.

Expressioni

Gene expression databases

BgeeiA8JQ65.

Interactioni

Protein-protein interaction databases

BioGridi624993. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8JQ65.
SMRiA8JQ65. Positions 81-178, 196-245, 248-323, 1832-1893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PH
Add
BLAST
Domaini349 – 485137DAGKc
Add
BLAST
Domaini1832 – 189564SAM
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
GeneTreeiENSGT00750000117493.
InParanoidiQ86NT9.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8JQ65-1 [UniParc]FASTAAdd to Basket

« Hide

MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD     50
GDESESESEI ETEPARLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR 100
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
ASVGKDIIEQ ADGIIMPHQW MEGNLPVSSM CAVCKKTCGS VLRLQDWRCL 300
WCRATVHVAC RPQMAVACPI GPAKLSVVPP TSVHSISTDD AWDVASPKGN 350
FSPLLVFVNS KSGDNQGVKF LRRFKQLLNP AQVFDLISTG PSLGLRLFRH 400
FEMFRILVCS GDGSVGWVLS EIDRFNMHKQ CQVAVMPLGT GNDLARVLGW 450
GSSCDDDTHL PQILERYESA STKMLDRWSI MVFEKAIPVP KTPKMSISTE 500
QEAMLTGMVT SANHHLRFIV ETNDTQTLIR STRNLCDTVD DLVCRISEHH 550
KDDEQLAVKC DILRQKLNML LDALQEEEIG AHSGDDLIAT IRSLIARSIP 600
VTPGSNAYLL NPNISIEKTE KDQINTKERR NSRSLRSSEK EALQCRANSV 650
KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKLPTASGES TPCTSPLPII 700
PPINIISPTM ETSRLTCISP LPDTRRDSVD ENFFNSINLP APRQFADSRR 750
SSGVEVIQEI EEGANGETVY RKSRMSLTGG ANIDDAGNRL SPCSDAGENT 800
PTERKVDFLR VPIHTGEPIV DPLCDYRPHE VFERTYYMTR EMDKGKEKDK 850
EKDKPVEIDK EKDTCVEKEG SMPAEKLVHT CNLQVPGVVV TPNPQNVYSS 900
ASITIIDTDA QTTTEQSSSD DLGGEASDVL SAISNEECSV ASEIFDKQDA 950
GQTVGDIIQN MDASNFTHID SPETSDETEA MPGESIMDDI SSVLGHDITY 1000
ALQDNTLTDD TTTLCSEHAG PPKPPRKKSL SALSRTQAHP RRRNSSPPRM 1050
ARLARMDSDD NPQQFGFENI VFEIDNRCDD QKMREPPRYC SLAQFVEGND 1100
IARQSFKQLM LEQHRGGDND SDYPEHEQTP TNKGANLLAT TSEDELSTQT 1150
AIKIEIQDID ATVRNLNSSM KPNTILTTST SPTKKSGHGQ DVKRITFDES 1200
CKKESFDDVN PNYPQISVVV RPPTPLRGDC IKPTVSLLPV SSGGAMTVSM 1250
TCSGMLGVRA MNASEIRRHS SHAPGLAVRE FDKDKDRRHS GFNPNQLTLD 1300
PEHARFLSSS PAASRRISCG SLFKPNEALP NLQTLKGSKS SLFMGSTLFG 1350
FDHLASAEKD KEEKSGKDKE KTPTDETNRK LPIINPLVRL PNWPNLANGG 1400
GFISKCLLAN ADTLCAAVSP LMDPDETLLA GYHEKCVMNN YFGIGIDAKI 1450
SLDFHNKREE HPEKCRSRAR NYMWYGVLGS KQLLQKTCKN LEQRVQLECD 1500
GQRIPLPELQ GIVILNIPSF MGGTNFWGSS KKDDIFLPPS FDDRVLEVVA 1550
VFGSVQMAAS RLINLQHHRI AQCQSVQINI LGDEEIPIQV DGEAWLQPPG 1600
MIRILHKNRV QMLCRNRSLE LSLKSWQEKQ RQHSISIQRD ASSTASEHAN 1650
STDEVISERE CYVLLNFIEA VSSLVKWVKF LIISHPALQH DLYEVACRAS 1700
EALESIHPQG KLLEGPSLRT KLVEVIDSSR QLYDDACTLL RDRGHSLILR 1750
EDLETKLSAA LANMEMELKK CSVQKCIDGK LRAYFNVLAP NEESDGRRKS 1800
RPFWVRLRSG STAGQQAFKP PLTNTREAAN NWSVNEVVTW LETMQLSEYV 1850
DSFLKNDIRG KELLTLGRRD LKDLGVVKVG HVKRILQAIK DLSEN 1895
Length:1,895
Mass (Da):211,659
Last modified:December 4, 2007 - v1
Checksum:iC152645B61070314
GO

Sequence cautioni

The sequence AAO39647.1 differs from that shown. Reason: Frameshift and deletion of residues 1685-1699.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1192 – 121524Missing in AAO39647. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: ABW08617.1.
BT003643 mRNA. Translation: AAO39647.1. Sequence problems.
RefSeqiNP_001097704.1. NM_001104234.4.
UniGeneiDm.17099.

Genome annotation databases

EnsemblMetazoaiFBtr0112625; FBpp0111537; FBgn0085413.
GeneIDi5740362.
KEGGidme:Dmel_CG34384.
UCSCiCG34384-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: ABW08617.1 .
BT003643 mRNA. Translation: AAO39647.1 . Sequence problems.
RefSeqi NP_001097704.1. NM_001104234.4.
UniGenei Dm.17099.

3D structure databases

ProteinModelPortali A8JQ65.
SMRi A8JQ65. Positions 81-178, 196-245, 248-323, 1832-1893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 624993. 1 interaction.

Proteomic databases

PaxDbi A8JQ65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0112625 ; FBpp0111537 ; FBgn0085413 .
GeneIDi 5740362.
KEGGi dme:Dmel_CG34384.
UCSCi CG34384-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0085413. CG34384.

Phylogenomic databases

eggNOGi NOG328046.
GeneTreei ENSGT00750000117493.
InParanoidi Q86NT9.
KOi K00901.
OrthoDBi EOG7DVD9B.

Miscellaneous databases

GenomeRNAii 5740362.
NextBioi 20891401.
PROi A8JQ65.

Gene expression databases

Bgeei A8JQ65.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1080-1895.
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiDGKH_DROME
AccessioniPrimary (citable) accession number: A8JQ65
Secondary accession number(s): Q86NT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi