Reviewed,
UniProtKB/Swiss-Prot A8IPW5 (DUT_AZOC5)
Last modified
November 3, 2009.
Version 13.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolase Short name=dUTPase EC=3.6.1.23 Alternative name(s): dUTP pyrophosphatase | ||||
| Gene names |
| ||||
| Organism | Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 438753 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium |
Protein attributes
| Sequence length | 157 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. |
| Catalytic activity | dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 |
| Cofactor | Magnesium By similarity. |
| Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116 |
| Sequence similarities | Belongs to the dUTPase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | dUTP metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 157 | 157 | Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116 | PRO_1000071353 | |||||
Regions | |||||||||
| Region | 73 – 75 | 3 | Substrate binding By similarity | ||||||
| Region | 90 – 92 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 86 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AP009384 Genomic DNA. Translation: BAF86705.1. | |
| RefSeq | YP_001523623.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5688970. |
| GenomeReviews | Gene locus AZC_0707 in contig AP009384_GR. |
| KEGG | azc:AZC_0707. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | MVIAPVT. |
Family and domain databases | |
| HAMAP | MF_00116. [Tree] |
| InterPro | IPR008180. DeoxyUTP_pyroPase_dom. IPR008181. dUTP_pyrophosphatase_subfam_1. [Graphical view] |
| Pfam | PF00692. dUTPase. 1 hit. [Graphical view] |
| ProDom | PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00576. dut. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DUT_AZOC5 | ||||||||
| Accession | Primary (citable) accession number: A8IPW5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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