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A8IMK0

- SYL_AZOC5

UniProt

A8IMK0 - SYL_AZOC5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei630 – 6301ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACAU438753:GJF3-570-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:AZC_0567
    OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
    Taxonomic identifieri438753 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
    ProteomesiUP000000270: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Leucine--tRNA ligasePRO_1000071108Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi438753.AZC_0567.

    Structurei

    3D structure databases

    ProteinModelPortaliA8IMK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi627 – 6315"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8IMK0-1 [UniParc]FASTAAdd to Basket

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    MSTDRYNARD AEPRWQAIWN ERGIFRTRND DPRPKFFVME MFPYPSGRIH    50
    IGHGRNYVMG DVLARYKRMQ GFNVLHPMGW DSFGLPAENA AIERGIHPKS 100
    WTYENIASMK EQLQLLGLSL DWNREVATCD PSYYAEQQRL FLDLFENDLA 150
    YRKESEVNWD PVDNTVLANE QVIDGRGWRS GAVVERRKLN QWFFRITAFA 200
    QELLDAIDTL DRWPDKVRLM QRNWIGRSEG LEVLFELSKG SVAAAGTSAV 250
    KVYTTRPDTL FGASFLALSP DHPLTQHLAA TRPDLAAFVA DCKTGGTSAE 300
    AIETQEKKGF DTGLTVVHPL DAARTVPVYV ANFVLMDYGT GAIFGCPAHD 350
    QRDLDFARKY GLTVTPVVLP PGADPAVFAV GSEAYDGEGT LYNSQFLDGL 400
    SIADAKEQVA RRLERFRVGE QPQGTRKVNF RLRDWGISRQ RYWGCPIPII 450
    HCDSCGPVAV PREQLPVELP DDVTFDRPGN PLDRAKAWRD VPCPKCGAPA 500
    RRETDTMDTF VDSSWYFLRY ASDNPDKPLD KDAVRHWLPV DQYIGGIEHA 550
    ILHLLYSRFF TRALKACGRV DVAEPFAGLF TQGMIVHETY KDKDGRWLFP 600
    EEVKLLGDGK AEKLDDGSPV TVGPPEKMSK SKKNVVPPEV VVDTYGVDAG 650
    RWFMLSDTPP ERDSEWTQSG IEGAWRFVQR VWRQVQEAIE LGAPKGADKP 700
    ASFDAAATAL RRAAHGLAHQ VADDVERLRF NVAVAHVHEF ANAFGQAIAS 750
    ARTASPVPAD LAFALREAAE IVTRVVGPMV PHLAEECWAA LGYDTLLAEA 800
    AWPKAEPELL VENTITLPIQ INGKKRDDIT VPRDATAAEV EAAVLEMESV 850
    RRALDGKAPK RIIVVPQRIV NVVA 874
    Length:874
    Mass (Da):97,619
    Last modified:December 4, 2007 - v1
    Checksum:iB7DC946BFD5677C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF86565.1.
    RefSeqiWP_012169098.1. NC_009937.1.
    YP_001523483.1. NC_009937.1.

    Genome annotation databases

    EnsemblBacteriaiBAF86565; BAF86565; AZC_0567.
    GeneIDi5691868.
    KEGGiazc:AZC_0567.
    PATRICi21017619. VBIAzoCau17976_0591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF86565.1 .
    RefSeqi WP_012169098.1. NC_009937.1.
    YP_001523483.1. NC_009937.1.

    3D structure databases

    ProteinModelPortali A8IMK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 438753.AZC_0567.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF86565 ; BAF86565 ; AZC_0567 .
    GeneIDi 5691868.
    KEGGi azc:AZC_0567.
    PATRICi 21017619. VBIAzoCau17976_0591.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ACAU438753:GJF3-570-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
      Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43989 / DSM 5975 / ORS 571.

    Entry informationi

    Entry nameiSYL_AZOC5
    AccessioniPrimary (citable) accession number: A8IMK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3