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A8IMK0

- SYL_AZOC5

UniProt

A8IMK0 - SYL_AZOC5

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Protein
Leucine--tRNA ligase
Gene
leuS, AZC_0567
Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAU438753:GJF3-570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:AZC_0567
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
ProteomesiUP000000270: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Leucine--tRNA ligaseUniRule annotation
PRO_1000071108Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_0567.

Structurei

3D structure databases

ProteinModelPortaliA8IMK0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi627 – 6315"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8IMK0-1 [UniParc]FASTAAdd to Basket

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MSTDRYNARD AEPRWQAIWN ERGIFRTRND DPRPKFFVME MFPYPSGRIH    50
IGHGRNYVMG DVLARYKRMQ GFNVLHPMGW DSFGLPAENA AIERGIHPKS 100
WTYENIASMK EQLQLLGLSL DWNREVATCD PSYYAEQQRL FLDLFENDLA 150
YRKESEVNWD PVDNTVLANE QVIDGRGWRS GAVVERRKLN QWFFRITAFA 200
QELLDAIDTL DRWPDKVRLM QRNWIGRSEG LEVLFELSKG SVAAAGTSAV 250
KVYTTRPDTL FGASFLALSP DHPLTQHLAA TRPDLAAFVA DCKTGGTSAE 300
AIETQEKKGF DTGLTVVHPL DAARTVPVYV ANFVLMDYGT GAIFGCPAHD 350
QRDLDFARKY GLTVTPVVLP PGADPAVFAV GSEAYDGEGT LYNSQFLDGL 400
SIADAKEQVA RRLERFRVGE QPQGTRKVNF RLRDWGISRQ RYWGCPIPII 450
HCDSCGPVAV PREQLPVELP DDVTFDRPGN PLDRAKAWRD VPCPKCGAPA 500
RRETDTMDTF VDSSWYFLRY ASDNPDKPLD KDAVRHWLPV DQYIGGIEHA 550
ILHLLYSRFF TRALKACGRV DVAEPFAGLF TQGMIVHETY KDKDGRWLFP 600
EEVKLLGDGK AEKLDDGSPV TVGPPEKMSK SKKNVVPPEV VVDTYGVDAG 650
RWFMLSDTPP ERDSEWTQSG IEGAWRFVQR VWRQVQEAIE LGAPKGADKP 700
ASFDAAATAL RRAAHGLAHQ VADDVERLRF NVAVAHVHEF ANAFGQAIAS 750
ARTASPVPAD LAFALREAAE IVTRVVGPMV PHLAEECWAA LGYDTLLAEA 800
AWPKAEPELL VENTITLPIQ INGKKRDDIT VPRDATAAEV EAAVLEMESV 850
RRALDGKAPK RIIVVPQRIV NVVA 874
Length:874
Mass (Da):97,619
Last modified:December 4, 2007 - v1
Checksum:iB7DC946BFD5677C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF86565.1.
RefSeqiWP_012169098.1. NC_009937.1.
YP_001523483.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF86565; BAF86565; AZC_0567.
GeneIDi5691868.
KEGGiazc:AZC_0567.
PATRICi21017619. VBIAzoCau17976_0591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF86565.1 .
RefSeqi WP_012169098.1. NC_009937.1.
YP_001523483.1. NC_009937.1.

3D structure databases

ProteinModelPortali A8IMK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 438753.AZC_0567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF86565 ; BAF86565 ; AZC_0567 .
GeneIDi 5691868.
KEGGi azc:AZC_0567.
PATRICi 21017619. VBIAzoCau17976_0591.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ACAU438753:GJF3-570-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
    Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43989 / DSM 5975 / ORS 571.

Entry informationi

Entry nameiSYL_AZOC5
AccessioniPrimary (citable) accession number: A8IMK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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