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Protein

Catalase-peroxidase

Gene

katG

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111Transition state stabilizerUniRule annotation1
Active sitei115Proton acceptorUniRule annotation1
Metal bindingi275Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei6665. AZcaCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:AZC_3290
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_000035472323 – 744Catalase-peroxidaseAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki114 ↔ 234Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-260)UniRule annotation
Cross-linki234 ↔ 260Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-114)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA8IHK8.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi438753.AZC_3290.

Structurei

3D structure databases

ProteinModelPortaliA8IHK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8IHK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRARRCTD RCARMSERSM NATTETPTGK CPVAHGTGGT QNRDWWPNQL
60 70 80 90 100
RVDLLNLHSP KSDPLGAAFD YRAEFKKLDY EALKNDLRKL MTDSQDWWPA
110 120 130 140 150
DFGNYGPQFV RMAWHSAGTY RLADGRGGGG RGQQRFAPLN SWPDNVNIDK
160 170 180 190 200
SRRLLWPIKQ KYGQKISWAD LMILTGNVAL ETMGFRTFGF AGGREDTWEP
210 220 230 240 250
DQDVFWGSET AWLSHRTLEK FDAPLGATEM GLIYVNPEGP DRNGDPISAA
260 270 280 290 300
KFIRETFARM AMNDEETVAL IGGGHTFGKT HGAAAESHKG PDPEAAALEA
310 320 330 340 350
QGLGWASNYG TGHGADTIGS GLEVTWTQTP AQWSNFFFEN LFKYEWVQTR
360 370 380 390 400
SPAGAIQWEA KDGPDIIPDA HNPEKKHKPT MLTTDLSLRF DPIYEKISRR
410 420 430 440 450
FLENPQAFAE AFARAWFKLT HRDLGPRSRY LGPEVPREVL LWQDPVPAVD
460 470 480 490 500
HPLIDDADAA ALKAKVLASG LTVSELVGTA WASASTFRGG DKRGGANGAR
510 520 530 540 550
IRLAPQKDWA VNQPEQIDKV LKALTRIQGE FNLNASDGKK VSLADVIVLA
560 570 580 590 600
GNAGVEEAAK AAGHDVSVPF APGRTDASQA ETDADSFKWL EPAADGFRNY
610 620 630 640 650
QKDGLAVPAE VALIDKAQLL TLTAPELTVL IGGLRAININ VDGAKHGVFT
660 670 680 690 700
DKPGALTTDF FTNLLDMSTQ WKAAGESNDV YEGRDRQTGE LKWTGTRVDL
710 720 730 740
VFGSNSILRA LAEVYAASDA KDKFVTDFVA AWTKVMNLDR FDLA
Length:744
Mass (Da):81,788
Last modified:December 4, 2007 - v1
Checksum:i7CBBA65A5AE19CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA. Translation: BAF89288.1.

Genome annotation databases

EnsemblBacteriaiBAF89288; BAF89288; AZC_3290.
KEGGiazc:AZC_3290.
PATRICi21023399. VBIAzoCau17976_3446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA. Translation: BAF89288.1.

3D structure databases

ProteinModelPortaliA8IHK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi438753.AZC_3290.

Protein family/group databases

PeroxiBasei6665. AZcaCP01.

Proteomic databases

PRIDEiA8IHK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF89288; BAF89288; AZC_3290.
KEGGiazc:AZC_3290.
PATRICi21023399. VBIAzoCau17976_3446.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_AZOC5
AccessioniPrimary (citable) accession number: A8IHK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.