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A8IG13

- TRMB_AZOC5

UniProt

A8IG13 - TRMB_AZOC5

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, AZC_0015
Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei113 – 1131S-adenosyl-L-methionine By similarity
Active sitei135 – 1351 By similarity
Binding sitei135 – 1351S-adenosyl-L-methionine By similarity
Binding sitei139 – 1391Substrate By similarity
Binding sitei171 – 1711Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciACAU438753:GJF3-15-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:AZC_0015
    OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
    Taxonomic identifieri438753 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
    ProteomesiUP000000270: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_1000072995Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi438753.AZC_0015.

    Structurei

    3D structure databases

    ProteinModelPortaliA8IG13.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni209 – 2124Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8IG13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTALSETEHK GAFYGRRVGK TLRQGQQQAL ARTLPRYLID LPTVAEPAAL    50
    FPCPVDEIRL EIGFGGGEHL LSEAKRFPRA GYIGIEPFLN GMAKAVLELD 100
    LAPQENVRLF NLDAALLLAR LPEGSVSQVE LLYPDPWPKR RHWKRRFVRP 150
    DNLDLLARAL KPGGVFRFAS DVPDYVDWTL REVRAHPAFR WTQTRADDWR 200
    TPYEGWPGTR YEAKAIAAGR VPTYLSFARV 230
    Length:230
    Mass (Da):26,108
    Last modified:December 4, 2007 - v1
    Checksum:iD9F1B2D6A9D3F782
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF86013.1.
    RefSeqiWP_012168546.1. NC_009937.1.
    YP_001522931.1. NC_009937.1.

    Genome annotation databases

    EnsemblBacteriaiBAF86013; BAF86013; AZC_0015.
    GeneIDi5688037.
    KEGGiazc:AZC_0015.
    PATRICi21016461. VBIAzoCau17976_0015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF86013.1 .
    RefSeqi WP_012168546.1. NC_009937.1.
    YP_001522931.1. NC_009937.1.

    3D structure databases

    ProteinModelPortali A8IG13.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 438753.AZC_0015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF86013 ; BAF86013 ; AZC_0015 .
    GeneIDi 5688037.
    KEGGi azc:AZC_0015.
    PATRICi 21016461. VBIAzoCau17976_0015.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci ACAU438753:GJF3-15-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
      Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43989 / DSM 5975 / ORS 571.

    Entry informationi

    Entry nameiTRMB_AZOC5
    AccessioniPrimary (citable) accession number: A8IG13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 4, 2007
    Last modified: September 3, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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