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A8IG13

- TRMB_AZOC5

UniProt

A8IG13 - TRMB_AZOC5

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Active sitei135 – 1351By similarity
Binding sitei135 – 1351S-adenosyl-L-methionineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciACAU438753:GJF3-15-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:AZC_0015
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
ProteomesiUP000000270: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferasePRO_1000072995Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_0015.

Structurei

3D structure databases

ProteinModelPortaliA8IG13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2124Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiRAFYGRR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8IG13 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTALSETEHK GAFYGRRVGK TLRQGQQQAL ARTLPRYLID LPTVAEPAAL
60 70 80 90 100
FPCPVDEIRL EIGFGGGEHL LSEAKRFPRA GYIGIEPFLN GMAKAVLELD
110 120 130 140 150
LAPQENVRLF NLDAALLLAR LPEGSVSQVE LLYPDPWPKR RHWKRRFVRP
160 170 180 190 200
DNLDLLARAL KPGGVFRFAS DVPDYVDWTL REVRAHPAFR WTQTRADDWR
210 220 230
TPYEGWPGTR YEAKAIAAGR VPTYLSFARV
Length:230
Mass (Da):26,108
Last modified:December 4, 2007 - v1
Checksum:iD9F1B2D6A9D3F782
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF86013.1.
RefSeqiYP_001522931.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF86013; BAF86013; AZC_0015.
GeneIDi5688037.
KEGGiazc:AZC_0015.
PATRICi21016461. VBIAzoCau17976_0015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF86013.1 .
RefSeqi YP_001522931.1. NC_009937.1.

3D structure databases

ProteinModelPortali A8IG13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 438753.AZC_0015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF86013 ; BAF86013 ; AZC_0015 .
GeneIDi 5688037.
KEGGi azc:AZC_0015.
PATRICi 21016461. VBIAzoCau17976_0015.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi RAFYGRR.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci ACAU438753:GJF3-15-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
    Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43989 / DSM 5975 / ORS 571.

Entry informationi

Entry nameiTRMB_AZOC5
AccessioniPrimary (citable) accession number: A8IG13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3