Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8IE48

- A8IE48_HUMAN

UniProt

A8IE48 - A8IE48_HUMAN

Protein
Submitted name:

GA binding protein transcription factor alpha subunit 60kDa

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. in utero embryonic development Source: Ensembl
    2. negative regulation of megakaryocyte differentiation Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GA binding protein transcription factor alpha subunit 60kDaImported
    Submitted name:
    GA binding protein transcription factor, alpha subunit 60kDaImported
    Submitted name:
    GA binding protein transcription factor, alpha subunit 60kDa, isoform CRA_aImported
    Submitted name:
    Nuclear respiratory factor 2 alpha subunitImported
    Gene namesi
    Name:GABPAImported
    ORF Names:hCG_401151Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28485.

    Structurei

    3D structure databases

    SMRiA8IE48. Positions 35-121, 168-254, 320-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.UniRule annotation
    Contains 1 ETS DNA-binding domain.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG051687.
    KOiK09441.
    OMAiGIPYDPV.
    PhylomeDBiA8IE48.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001703. GABP_alpha. 1 hit.
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8IE48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN    50
    LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS 100
    YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK 150
    HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW 200
    VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY 250
    VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 300
    RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL 350
    NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV 400
    CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT 450
    EKDN 454
    Length:454
    Mass (Da):51,295
    Last modified:December 4, 2007 - v1
    Checksum:i1AF2ABBBC79191DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU159453 mRNA. Translation: ABV90873.1.
    EU627790 Genomic DNA. Translation: ACD11490.1.
    JQ313900 mRNA. Translation: AFH41795.1.
    CH471079 Genomic DNA. Translation: EAX09967.1.
    CH471079 Genomic DNA. Translation: EAX09968.1.
    CH471079 Genomic DNA. Translation: EAX09969.1.
    RefSeqiNP_001184226.1. NM_001197297.1.
    NP_002031.2. NM_002040.3.
    XP_005260995.1. XM_005260938.2.
    XP_005260996.1. XM_005260939.2.
    UniGeneiHs.473470.

    Genome annotation databases

    GeneIDi2551.
    KEGGihsa:2551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU159453 mRNA. Translation: ABV90873.1 .
    EU627790 Genomic DNA. Translation: ACD11490.1 .
    JQ313900 mRNA. Translation: AFH41795.1 .
    CH471079 Genomic DNA. Translation: EAX09967.1 .
    CH471079 Genomic DNA. Translation: EAX09968.1 .
    CH471079 Genomic DNA. Translation: EAX09969.1 .
    RefSeqi NP_001184226.1. NM_001197297.1.
    NP_002031.2. NM_002040.3.
    XP_005260995.1. XM_005260938.2.
    XP_005260996.1. XM_005260939.2.
    UniGenei Hs.473470.

    3D structure databases

    SMRi A8IE48. Positions 35-121, 168-254, 320-429.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 2551.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2551.
    KEGGi hsa:2551.

    Organism-specific databases

    CTDi 2551.
    PharmGKBi PA28485.

    Phylogenomic databases

    HOVERGENi HBG051687.
    KOi K09441.
    OMAi GIPYDPV.
    PhylomeDBi A8IE48.

    Miscellaneous databases

    ChiTaRSi GABPA. human.
    GenomeRNAii 2551.
    NextBioi 10071.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001703. GABP_alpha. 1 hit.
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. Yang S.J., Li K.N., Zhang Y.Q.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HepatomaImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
    5. "Isolation of a novel GABPalpha-interacting co-factor, E4TF-1 Binding Methyltransferase (EBM), which encodes a putative methyltransferase."
      Baron B.M.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA8IE48_HUMAN
    AccessioniPrimary (citable) accession number: A8IE48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.