Reviewed, UniProtKB/Swiss-Prot A8ICW0 (PYRB_AZOC5)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	AZC_2851

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP]

Taxonomic identifier

438753 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321072

Sequences

	Sequence		Length	Mass (Da)
	A8ICW0-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 2E66C91ACBAAACCB	FASTA	321	34,923
	10 20 30 40 50 60 MITAPFFTLD RRDLLGIEGL SAPEIVGLLD LAEEFVVLNR QIEKKRSTLR GRTQVNLFFE 70 80 90 100 110 120 ASTRTQSSFE LAGKRLGADV MNMSVGNSSV KKGETLIDTA MTLNAMRPDI LVVRHHASGA 130 140 150 160 170 180 VALLARKVDC CVVNAGDGAH EHPTQALLDA LTIRRNKGRI EGLTVAVCGD VLHSRVARSN 190 200 210 220 230 240 ILLLHTLGAR VRVVAPSTLL PTGIENFGVE VHRSMESGLE GADIVMMLRL QRERMAGSFI 250 260 270 280 290 300 PSVKEYFHYY GLDEAKLKRA KPDALVMHPG PMNRGVEIDS AVADGAQSLI REQVEMGVAV 310 320 RMAVLDALAR KLPNATGAER D

References

[1]

"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009384 Genomic DNA. Translation: BAF88849.1.
RefSeq	YP_001525767.1.
3D structure databases
SMR	A8ICW0. Positions 9-309.
ModBase	Search...
Genome annotation databases
GeneID	5689256.
GenomeReviews	Gene locus AZC_2851 in contig AP009384_GR.
KEGG	azc:AZC_2851.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VMMLRVQ.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_AZOC5

Accession

Primary (citable) accession number: A8ICW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 4, 2007
Last modified:	February 9, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)