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A8IA58

- RBKTP_AZOC5

UniProt

A8IA58 - RBKTP_AZOC5

Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

    Catalytic activityi

    ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase activity Source: InterPro
    3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
    4. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. organic phosphonate transport Source: UniProtKB-KW
    3. pyrimidine nucleobase metabolic process Source: InterPro
    4. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Alkylphosphonate uptake

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACAU438753:GJF3-2497-MONOMER.
    UniPathwayiUPA00087; UER00175.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
    Including the following 2 domains:
    Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
    Putative thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:phnN
    Ordered Locus Names:AZC_2467
    OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
    Taxonomic identifieri438753 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
    ProteomesiUP000000270: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000314696Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi438753.AZC_2467.

    Structurei

    3D structure databases

    ProteinModelPortaliA8IA58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 193193Ribose 1,5-bisphosphokinaseAdd
    BLAST
    Regioni194 – 693500ThymidinephosphorylaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
    In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiGCIAWNG.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8IA58-1 [UniParc]FASTAAdd to Basket

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    MSVMGSGLFF FVVGPSGSGK DTLIEGAKAA LGPTGRYVFA RRAITRPADA    50
    GGEAHEALSV DQFDAVLAQG GFLIHWEAHG LKYGLRATLL DDMAAGRHVI 100
    ANGSRAMVAA LAERVPHLVV VEITAPEAVL AERLKGRGRE GAENIAARLE 150
    RKVPPFPESV TVIQVPNDST PRAGIEKFVA ALVAQTARLR LVRMAIETGR 200
    RNVAFLARGN TVVAAPDYLG PGRVDLIGEG RSIRAEVALV GDALLPSDAV 250
    GLSSEAFGAL GLPEGAELVL TRTPVPESRA ALRRKIQGAT LDEGAYAQVV 300
    GDIVEGRYPD SEVAGFLVAA DRSLSDDEVL ALAKVRAKFA SRITWDEPMV 350
    VDKHSMGGIP GSRITMIVVP IVAAHGLAIP KTSSRAITSA AGTADAMETL 400
    ARVDLDSAEV RRTVERARGC IAWNGRLSHS ALDDVMNAIT RPLGLDSTRW 450
    SVASILSKKL AAGSTHVVID LPFGARARVK GAGEAHEMAR LFEQVGAGLG 500
    LTVEAIPTDG SAPIGRGIGP ALEVRDVLWV LEDHSEAPPD LKEKALFFAS 550
    RILAWDPAVG PDRARARAEE LLASGAARAA LERIVEAQGR WSEPVRPARL 600
    THTVTAQNDG QVSDIDGFAV AGIARLAGAP LDKGAGIDLK ARVGDVVRAG 650
    DPLFVIHAST AADLEAAAGA ALAFDGYGIM MDGKAFRRIN PER 693
    Length:693
    Mass (Da):72,760
    Last modified:December 4, 2007 - v1
    Checksum:i8847CD4C7646E9EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF88465.1.
    RefSeqiYP_001525383.1. NC_009937.1.

    Genome annotation databases

    EnsemblBacteriaiBAF88465; BAF88465; AZC_2467.
    GeneIDi5687914.
    KEGGiazc:AZC_2467.
    PATRICi21021651. VBIAzoCau17976_2580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009384 Genomic DNA. Translation: BAF88465.1 .
    RefSeqi YP_001525383.1. NC_009937.1.

    3D structure databases

    ProteinModelPortali A8IA58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 438753.AZC_2467.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF88465 ; BAF88465 ; AZC_2467 .
    GeneIDi 5687914.
    KEGGi azc:AZC_2467.
    PATRICi 21021651. VBIAzoCau17976_2580.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi GCIAWNG.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00175 .
    BioCyci ACAU438753:GJF3-2497-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
      Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43989 / DSM 5975 / ORS 571.

    Entry informationi

    Entry nameiRBKTP_AZOC5
    AccessioniPrimary (citable) accession number: A8IA58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3