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A8IA58

- RBKTP_AZOC5

UniProt

A8IA58 - RBKTP_AZOC5

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Protein
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Gene
phnN, AZC_2467
Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity.UniRule annotation

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorylase activity Source: InterPro
  3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
  4. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. organic phosphonate transport Source: UniProtKB-KW
  3. pyrimidine nucleobase metabolic process Source: InterPro
  4. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Alkylphosphonate uptake

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAU438753:GJF3-2497-MONOMER.
UniPathwayiUPA00087; UER00175.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:AZC_2467
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
ProteomesiUP000000270: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylaseUniRule annotation
PRO_0000314696Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_2467.

Structurei

3D structure databases

ProteinModelPortaliA8IA58.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 193193Ribose 1,5-bisphosphokinaseUniRule annotation
Add
BLAST
Regioni194 – 693500ThymidinephosphorylaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiGCIAWNG.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
TIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8IA58-1 [UniParc]FASTAAdd to Basket

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MSVMGSGLFF FVVGPSGSGK DTLIEGAKAA LGPTGRYVFA RRAITRPADA    50
GGEAHEALSV DQFDAVLAQG GFLIHWEAHG LKYGLRATLL DDMAAGRHVI 100
ANGSRAMVAA LAERVPHLVV VEITAPEAVL AERLKGRGRE GAENIAARLE 150
RKVPPFPESV TVIQVPNDST PRAGIEKFVA ALVAQTARLR LVRMAIETGR 200
RNVAFLARGN TVVAAPDYLG PGRVDLIGEG RSIRAEVALV GDALLPSDAV 250
GLSSEAFGAL GLPEGAELVL TRTPVPESRA ALRRKIQGAT LDEGAYAQVV 300
GDIVEGRYPD SEVAGFLVAA DRSLSDDEVL ALAKVRAKFA SRITWDEPMV 350
VDKHSMGGIP GSRITMIVVP IVAAHGLAIP KTSSRAITSA AGTADAMETL 400
ARVDLDSAEV RRTVERARGC IAWNGRLSHS ALDDVMNAIT RPLGLDSTRW 450
SVASILSKKL AAGSTHVVID LPFGARARVK GAGEAHEMAR LFEQVGAGLG 500
LTVEAIPTDG SAPIGRGIGP ALEVRDVLWV LEDHSEAPPD LKEKALFFAS 550
RILAWDPAVG PDRARARAEE LLASGAARAA LERIVEAQGR WSEPVRPARL 600
THTVTAQNDG QVSDIDGFAV AGIARLAGAP LDKGAGIDLK ARVGDVVRAG 650
DPLFVIHAST AADLEAAAGA ALAFDGYGIM MDGKAFRRIN PER 693
Length:693
Mass (Da):72,760
Last modified:December 4, 2007 - v1
Checksum:i8847CD4C7646E9EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF88465.1.
RefSeqiYP_001525383.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF88465; BAF88465; AZC_2467.
GeneIDi5687914.
KEGGiazc:AZC_2467.
PATRICi21021651. VBIAzoCau17976_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009384 Genomic DNA. Translation: BAF88465.1 .
RefSeqi YP_001525383.1. NC_009937.1.

3D structure databases

ProteinModelPortali A8IA58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 438753.AZC_2467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF88465 ; BAF88465 ; AZC_2467 .
GeneIDi 5687914.
KEGGi azc:AZC_2467.
PATRICi 21021651. VBIAzoCau17976_2580.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi GCIAWNG.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00175 .
BioCyci ACAU438753:GJF3-2497-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
TIGR02322. phosphon_PhnN. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
    Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43989 / DSM 5975 / ORS 571.

Entry informationi

Entry nameiRBKTP_AZOC5
AccessioniPrimary (citable) accession number: A8IA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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