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Protein

Argininosuccinate lyase

Gene

argH

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:AZC_4662Imported
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)Imported
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_4662.

Structurei

3D structure databases

ProteinModelPortaliA8I039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 302Lyase_1InterPro annotationAdd BLAST295
Domaini365 – 433ASL_C2InterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814:SF1. PTHR43814:SF1. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

A8I039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKMWGGRF STGPDAIMEE INVSIGFDQR LYAQDIAGSK AHAAMLSAQK
60 70 80 90 100
IIAAKDAQKI QKGLDTILSE IEAGKFTFRR DLEDIHMNVE SRLAELIGAP
110 120 130 140 150
AGRLHTARSR NDQVATDFRL YVRDTIDTLD EQMADLQRAL AEKALAHAGT
160 170 180 190 200
VMPGFTHLQN AQPVTFGHHL MAYVEMLGRD RGRFADARKR LNESPLGSAA
210 220 230 240 250
LAGTSFPIDR EATAAALGFD RPTANSLDGV SDRDFVMETL AAASICAVHL
260 270 280 290 300
SRFAEEIVIW TSPAFGLVKL TDAFTTGSSI MPQKRNPDAA ELARAKSGRI
310 320 330 340 350
IGALTGILVV MKGLPLAYAK DTQEDKEGTF DALSALSLVI AAIAGMVRDM
360 370 380 390 400
EPEATRMKAA AGQGYATATD LADWLVRTLN IPFREAHHVT GRIVALASER
410 420 430 440 450
GVPLHRLSLE EMQGVEKRIT QDVFSVLSVT NSVRSRTSYG GTAPARVRQQ
460
ARRWLKKLGP AA
Length:462
Mass (Da):50,124
Last modified:December 4, 2007 - v1
Checksum:i7D61171E1F880996
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA. Translation: BAF90660.1.
RefSeqiWP_012173181.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF90660; BAF90660; AZC_4662.
KEGGiazc:AZC_4662.

Similar proteinsi

Entry informationi

Entry nameiA8I039_AZOC5
AccessioniPrimary (citable) accession number: A8I039
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 27, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported