Reviewed,
UniProtKB/Swiss-Prot A8HZA8 (DDL_AZOC5)
Last modified
February 9, 2010.
Version 20.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: D-alanine--D-alanine ligase EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase D-Ala-D-Ala ligase | ||||
| Gene names |
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| Organism | Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 438753 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium |
Protein attributes
| Sequence length | 306 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation By similarity. HAMAP MF_00047 |
| Catalytic activity | ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP MF_00047 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00047. |
| Sequence similarities | Belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 306 | 306 | D-alanine--D-alanine ligase HAMAP MF_00047 | PRO_0000341057 | |||||
Regions | |||||||||
| Domain | 101 – 300 | 200 | ATP-grasp | ||||||
| Nucleotide binding | 128 – 182 | 55 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 250 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 267 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 267 | 1 | Magnesium or manganese 2 By similarity | ||||||
| Metal binding | 269 | 1 | Magnesium or manganese 2 By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AP009384 Genomic DNA. Translation: BAF90559.1. |
| RefSeq | YP_001527477.1. |
3D structure databases | |
| SMR | A8HZA8. Positions 1-302. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5689654. |
| GenomeReviews | Gene locus AZC_4561 in contig AP009384_GR. |
| KEGG | azc:AZC_4561. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG427092. |
| OMA | RSDFRWD. |
Family and domain databases | |
| HAMAP | MF_00047. Dala_Dala_lig. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR01205. D_ala_D_alaTIGR. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DDL_AZOC5 | ||||||||
| Accession | Primary (citable) accession number: A8HZA8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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