A8HX69 (KHSE_AZOC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	AZC_1467

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP]

Taxonomic identifier

438753 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000071978

Sequences

	Sequence		Length	Mass (Da)
	A8HX69 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: C8AD38CC6FE3BE04	FASTA	321	34,480
	10 20 30 40 50 60 MAVYTDVSAA SLSDYLAAYD IGTLVSYHGI AEGVENSNFL VQTTTASFIL TLYEKRVDPA 70 80 90 100 110 120 DLPFFIGLMQ HLAANGISCP QPVAMRDGTM LGTLAGRPCA IVTFLPGVSV RKPTAANCGQ 130 140 150 160 170 180 LGRALAQLHL AGAGFEITRR NALSVSGWRP LFEAAGPRTD TVHPGLAAII TEELAAHEAH 190 200 210 220 230 240 WPAALPAGVI HADLFPDNAF FLDDTLSGII DFYFACNDLF AYDVAVCLNA WCFEADGAFN 250 260 270 280 290 300 ATKGRALLAG YQAVRPMEAA EVEALPQLAR GAALRFLLTR LVDWLNVPEG ALVRPKDPLE 310 320 YLRKLRFHRA VASARDYGLA A

References

[1]

"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43989 / DSM 5975 / ORS 571.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009384 Genomic DNA. Translation: BAF87465.1.
RefSeq	YP_001524383.1. NC_009937.1.
3D structure databases
ProteinModelPortal	A8HX69.
SMR	A8HX69. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	A8HX69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5688245.
GenomeReviews	Gene locus AZC_1467 in contig AP009384_GR.
KEGG	azc:AZC_1467.
PATRIC	21019525. VBIAzoCau17976_1531.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	ACAU438753:AZC_1467-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_AZOC5

Accession

Primary (citable) accession number: A8HX69

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program