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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciACAU438753:G1G2W-843-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:AZC_0822
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003834131 – 380L-lactate dehydrogenaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_0822

Structurei

3D structure databases

ProteinModelPortaliA8HTC9
SMRiA8HTC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA
HOGENOMiHOG000217464
KOiK00101
OMAiWHGRAWS
OrthoDBiPOG091H00L7

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.701 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8HTC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISSPNDYR AAAKSRLPPF LFHYVDGGAY AEYTLRRNVE DLSHIALRQQ
60 70 80 90 100
VLRNVADLSL ETELFGQKLT MPVALAPVGL TGMLARRGEV QAAKAAQAKG
110 120 130 140 150
VPFTLSTVSV CPIEEVQSQC AKPIWFQLYV LKDRGFMRNA LERAQAAGIN
160 170 180 190 200
TLIFTVDMPV PGARYRDAHS GMSGRSGPTR RVLQAMVHPR WALDVGLLGK
210 220 230 240 250
PHDLGNISTY RGKPTNLADY IGWLAANFDP SISWKDLEWI RSFWKGPMII
260 270 280 290 300
KGILDPVDAR DAVAFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVGDD
310 320 330 340 350
LTVLADSGIR TGLDVVRMLA LGAKGVLLGR AFAYALATHG QAGVANLLDL
360 370 380
IEKEMRVAMA LTGARSIAEI TRDSLVGLPR
Length:380
Mass (Da):41,005
Last modified:December 4, 2007 - v1
Checksum:i48C9F002993F0C77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA Translation: BAF86820.1
RefSeqiWP_012169353.1, NC_009937.1

Genome annotation databases

EnsemblBacteriaiBAF86820; BAF86820; AZC_0822
KEGGiazc:AZC_0822

Similar proteinsi

Entry informationi

Entry nameiLLDD_AZOC5
AccessioniPrimary (citable) accession number: A8HTC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 4, 2007
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome