Reviewed, UniProtKB/Swiss-Prot A8HT29 (GCSPA_AZOC5)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	AZC_4248

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP]

Taxonomic identifier

438753 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000072767

Sequences

	Sequence		Length	Mass (Da)
	A8HT29-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: D776DEC3602BF231	FASTA	447	47,277
	10 20 30 40 50 60 MRYLPLTPED RTEMLARIGA PSVDALFADI PAAKLDPALA DLPAHKTELS VERTLGALSA 70 80 90 100 110 120 QNVPAGSVPF FVGAGAYRHH VPATVDHLIQ RSEFLTSYTP YQPEIAQGTL QYLFEFQTQV 130 140 150 160 170 180 GELTGMEVAN ASMYDGSTAA AEAVLMAHRV TKRRKAVVAG NVHPHYRETI ATLSLYADDA 190 200 210 220 230 240 VVALSPVPQG GEDILSAIDG ETSCVVVQSP DVFGNIVDLK PIAEKAHAAG ALLIAVFTEV 250 260 270 280 290 300 VSLGLIEPPG AQGADIVVGE GQSIGNPLTF GGPYVGLFAT RQKYVRQMPG RLAGETVDAS 310 320 330 340 350 360 GKRGFVLTLS TREQHIRREK ATSNICTNSG LCALAFTIHL TLLGETGLRK LARLNHANAC 370 380 390 400 410 420 KLADKLAAVP GVQVLNSAFF NEFTLRVPGK AVDVIEKLAA KGVLGGVPYA RLAPKAGLDD 430 440 LILVAATEIN TDEDRAAYAA ALKEVLA

References

[1]

"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009384 Genomic DNA. Translation: BAF90246.1.
RefSeq	YP_001527164.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5691343.
GenomeReviews	Gene locus AZC_4248 in contig AP009384_GR.
KEGG	azc:AZC_4248.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8HT29. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. [Graphical view]
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_AZOC5

Accession

Primary (citable) accession number: A8HT29

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 4, 2007
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)