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A8HSI3 (A8HSI3_AZOC5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP MF_01517
EC=1.1.1.37 HAMAP MF_01517
Gene names
Name:mdh HAMAP MF_01517
Ordered Locus Names:AZC_4186
OrganismAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP] EMBL BAF90184.1
Taxonomic identifier438753 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP MF_01517
Binding site931Substrate By similarity HAMAP MF_01517
Binding site991Substrate By similarity HAMAP MF_01517
Binding site1061NAD By similarity HAMAP MF_01517
Binding site1131NAD By similarity HAMAP MF_01517
Binding site1321Substrate By similarity HAMAP MF_01517
Binding site1631Substrate By similarity HAMAP MF_01517

Sequences

Sequence LengthMass (Da)Tools
A8HSI3 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: E2E65548FCB7E2C9

FASTA32734,590
        10         20         30         40         50         60 
MTKPAVRVAV TGAAGQICYS LLFRIANGDV YGKDQPVILQ LLDLPQAQNA VKGVVMELED 

        70         80         90        100        110        120 
CAFPLLAGVV ITDDPKVAFK DVDAAFLVGA RPRSKGMERA DLLLANAEIF KVQGAALNEV 

       130        140        150        160        170        180 
AKRDVKVLVV GNPANTNAYI TAKSAPDLPA GNITAMLRLD HNRALSQFAA KIGANSADIE 

       190        200        210        220        230        240 
KLVVWGNHSP TMFADYRFAT VKGQPLPKLV NDEDWYRGTL IPTVGKRGAA IIEARGLSSA 

       250        260        270        280        290        300 
ASAANAAVDH MRDWIHGTNG GWVSMGIASD GSYGIPEGIV FGFPAVCANG SYEVVKGLEI 

       310        320 
DAYAQSMLDI TLKELLEERA GVAAIVG

« Hide

References

[1]"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009384 Genomic DNA. Translation: BAF90184.1.
RefSeqYP_001527102.1. NC_009937.1.

3D structure databases

ProteinModelPortalA8HSI3.
SMRA8HSI3. Positions 3-323.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8HSI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5691151.
GenomeReviewsGene locus AZC_4186 in contig AP009384_GR.
KEGGazc:AZC_4186.
PATRIC21025259. VBIAzoCau17976_4365.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289884.
OMADPNVAFK.
ProtClustDBPRK05442.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8HSI3_AZOC5
AccessionPrimary (citable) accession number: A8HSI3
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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