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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei371 – 3711Required for activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAU438753:GJF3-4176-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:AZC_4127
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510ATP synthase subunit alphaPRO_1000073350Add
BLAST

Proteomic databases

PRIDEiA8HS15.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi438753.AZC_4127.

Structurei

3D structure databases

ProteinModelPortaliA8HS15.
SMRiA8HS15. Positions 22-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
HOGENOMiHOG000130111.
KOiK02111.
OMAiQVVSIWA.
OrthoDBiPOG091H01QH.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8HS15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRAAEISA ILKEQIQNFG REAEVSEVGQ VLSVGDGIAR VYGLDNVQAG
60 70 80 90 100
EMVEFENGTR GMALNLEIDN VGVVIFGSDR DIKEGQTVKR TGAIVDVPVG
110 120 130 140 150
RGLLGRVVDA LGNPIDGKGP IEATERRRVD VKAPGIIPRK SVHEPMQTGL
160 170 180 190 200
KAIDALIPIG RGQRELIIGD RQTGKTAVAL DAILNQKPLN VAGAPESQKL
210 220 230 240 250
YCVYVAVGQK RSTVAQFVKV LEEQGALEYS IVVAATASDP APMQFLAPFA
260 270 280 290 300
GTAMGEYFRD NGMHALIIHD DLSKQAVAYR QMSLLLRRPP GREAYPGDVF
310 320 330 340 350
YLHSRLLERA AKLNDENGAG SLTALPVIET QANDVSAYIP TNVISITDGQ
360 370 380 390 400
IFLESDLFYQ GIRPAVNVGL SVSRVGSSAQ IKAMKQVAGK IKGELAQYRE
410 420 430 440 450
LAAFAQFGSD LDASTQKLLN RGARLTELLK QSQFSPLKVE EQVVVIYAGT
460 470 480 490 500
NGYLDNLPLN KVREFEAGFL LAMRTQHQDL LDTIRTSKEL SKDSIANLTK
510
ALDAFAKSFA
Length:510
Mass (Da):55,188
Last modified:December 4, 2007 - v1
Checksum:iB601383C7E22BD7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA. Translation: BAF90125.1.
RefSeqiWP_012172647.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF90125; BAF90125; AZC_4127.
KEGGiazc:AZC_4127.
PATRICi21025141. VBIAzoCau17976_4306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA. Translation: BAF90125.1.
RefSeqiWP_012172647.1. NC_009937.1.

3D structure databases

ProteinModelPortaliA8HS15.
SMRiA8HS15. Positions 22-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi438753.AZC_4127.

Proteomic databases

PRIDEiA8HS15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF90125; BAF90125; AZC_4127.
KEGGiazc:AZC_4127.
PATRICi21025141. VBIAzoCau17976_4306.

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
HOGENOMiHOG000130111.
KOiK02111.
OMAiQVVSIWA.
OrthoDBiPOG091H01QH.

Enzyme and pathway databases

BioCyciACAU438753:GJF3-4176-MONOMER.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPA_AZOC5
AccessioniPrimary (citable) accession number: A8HS15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.