Reviewed, UniProtKB/Swiss-Prot A8HQP5 (AHPD_AZOC5)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	AZC_1050

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP]

Taxonomic identifier

438753 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359471
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8HQP5-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: A6BDED0A664A4CD1	FASTA	181	18,933
	10 20 30 40 50 60 MSIEALKTQL PAFAKDVKLN LSALPREDSL TEQQLYGLLV ACGYTTRNGT VAQALEAEAA 70 80 90 100 110 120 PHLSPAALDA AKAAASIMAM NNVYYRFTHL ASNKAYETLP AKLRMSVIGN PGVDKVDFEL 130 140 150 160 170 180 WSLAVSAMNG CGRCIDAHEA VLREAGLSEA QIQTAVRVGA IIASAAVALE AAGAGFPEAA E

References

[1]

"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571." Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009384 Genomic DNA. Translation: BAF87048.1.
RefSeq	YP_001523966.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5688393.
GenomeReviews	Gene locus AZC_1050 in contig AP009384_GR.
KEGG	azc:AZC_1050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAMNNVY.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_AZOC5

Accession

Primary (citable) accession number: A8HQP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	December 4, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)