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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciACAU438753:G1G2W-1048-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:AZC_1017
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000714371 – 228N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST228

Proteomic databases

PRIDEiA8HQ40

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_1017

Structurei

3D structure databases

ProteinModelPortaliA8HQ40
SMRiA8HQ40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

A8HQ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIEVKICGL STAETLEAAL AAGADLVGFV HFPKSPRHVP LEAAPALSRA
60 70 80 90 100
VAGRAAKVLL LVDPDDATLA AAVAAFQPDI IQLHGKESPE RVAAIRARTG
110 120 130 140 150
RPVMKALPVS GPADLAVVPA YAAVADRLLF DAKPAPDDTL PGGNGRVFDW
160 170 180 190 200
TLLAGLDPGR PVMLSGGLDA GNVSQALSVV RLDGVDVSSG VETAPGLKSP
210 220
EKILAFVRAV KAAEAASRPS RLKKVEAP
Length:228
Mass (Da):23,350
Last modified:December 4, 2007 - v1
Checksum:i3CF37A8FA9BDF608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009384 Genomic DNA Translation: BAF87015.1
RefSeqiWP_012169548.1, NC_009937.1

Genome annotation databases

EnsemblBacteriaiBAF87015; BAF87015; AZC_1017
KEGGiazc:AZC_1017

Similar proteinsi

Entry informationi

Entry nameiTRPF_AZOC5
AccessioniPrimary (citable) accession number: A8HQ40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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