A8H9B5 (A8H9B5_SHEPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I HAMAP MF_00223

Gene names

Name:	folE HAMAP MF_00223
Ordered Locus Names:	Spea_3842

Organism

Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP] EMBL ABV89152.1

Taxonomic identifier

398579 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 Nucleotide-binding Zinc HAMAP MF_00223
Molecular function	Hydrolase HAMAP MF_00223 EMBL ABV89152.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	113	1	Zinc By similarity HAMAP MF_00223
	Metal binding	116	1	Zinc By similarity HAMAP MF_00223
	Metal binding	184	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	A8H9B5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: AE4EA7DC764098D8	FASTA	219	24,315
	10 20 30 40 50 60 MTSKEAILSE SAQIVQSALI ERGLETPMLP SELSAEVRKD KIEHHMREIL TLMSLDLSDD 70 80 90 100 110 120 SLADTPRRIA KMYVDEIFSG LDYANFPKIT VIENKMGFDE MVKVNDISLT STCEHHLVTI 130 140 150 160 170 180 DGLATVAYLP RKNIIGLSKI NRIVRFFAQR PQVQERLTQQ VLVALQALLG TKDVAVKMDA 190 200 210 VHYCVKSRGV MDSTSSTTTT ALGGIFKSNP ATRAEFLSN

References

[1]

"Complete sequence of Shewanella pealeana ATCC 700345." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000851 Genomic DNA. Translation: ABV89152.1.
RefSeq	YP_001503687.1. NC_009901.1.
3D structure databases
ProteinModelPortal	A8H9B5.
SMR	A8H9B5. Positions 8-217.
ModBase	Search...
Protein-protein interaction databases
STRING	A8H9B5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5664226.
GenomeReviews	Gene locus Spea_3842 in contig CP000851_GR.
KEGG	spl:Spea_3842.
NMPDR	fig|398579.3.peg.3318.
PATRIC	23537887. VBIShePea72822_4010.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	VAVKIDA.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	SPEA398579:SPEA_3842-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8H9B5_SHEPA

Accession

Primary (citable) accession number: A8H9B5

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)