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Protein

UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.UniRule annotation

Catalytic activityi

UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H2O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. UDP-2,3-diacylglucosamine hydrolase (lpxH)
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Zinc; via tele nitrogenUniRule annotation
Metal bindingi238 – 2381Zinc; via tele nitrogenUniRule annotation
Metal bindingi242 – 2421ZincUniRule annotation
Active sitei265 – 2651Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3980-MONOMER.
UniPathwayiUPA00359; UER00478.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acyl-N-acetylglucosamine deacetylaseUniRule annotation (EC:3.5.1.108UniRule annotation)
Short name:
UDP-3-O-acyl-GlcNAc deacetylaseUniRule annotation
Alternative name(s):
UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylaseUniRule annotation
Gene namesi
Name:lpxCUniRule annotation
Ordered Locus Names:Spea_3806
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002608 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306UDP-3-O-acyl-N-acetylglucosamine deacetylasePRO_1000080229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_3806.

Structurei

3D structure databases

ProteinModelPortaliA8H979.
SMRiA8H979. Positions 1-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7C. Bacteria.
COG0774. LUCA.
HOGENOMiHOG000256663.
KOiK02535.
OMAiNSMLVKA.
OrthoDBiPOG091H0292.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC. 1 hit.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFQRTVKEM VKTTGVGLHS GNKVTLIIKP APVNTGIKLV RTDLSPAVEI
60 70 80 90 100
PAVADQVRET TMCTALVNDD GVRISTIEHL FAALAGLGID NAVIEVDAPE
110 120 130 140 150
IPIMDGSASP FVFLLQSVGI QEQNAAKKYI KITKPIRVED GDKWAELKPF
160 170 180 190 200
KGFRVDFAID FNHPEIARSQ QHMVMDFSSS AFIKDISRAR TFGFMRDIEY
210 220 230 240 250
LRANNLALGG SMENAVVLDE YRVLNPDGLR YEDEFVKHKI LDAFGDLYVA
260 270 280 290 300
GHAIVGEFCA YKTGHALNNQ LVRAMLAQQD AWEIVSFEKE ADAPVSFSVP

AGAVFA
Length:306
Mass (Da):33,660
Last modified:November 13, 2007 - v1
Checksum:i8FE0C06B77F8CAC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV89116.1.
RefSeqiWP_012156998.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV89116; ABV89116; Spea_3806.
KEGGispl:Spea_3806.
PATRICi23537813. VBIShePea72822_3973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV89116.1.
RefSeqiWP_012156998.1. NC_009901.1.

3D structure databases

ProteinModelPortaliA8H979.
SMRiA8H979. Positions 1-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398579.Spea_3806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV89116; ABV89116; Spea_3806.
KEGGispl:Spea_3806.
PATRICi23537813. VBIShePea72822_3973.

Phylogenomic databases

eggNOGiENOG4105C7C. Bacteria.
COG0774. LUCA.
HOGENOMiHOG000256663.
KOiK02535.
OMAiNSMLVKA.
OrthoDBiPOG091H0292.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00478.
BioCyciSPEA398579:GHG5-3980-MONOMER.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC. 1 hit.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPXC_SHEPA
AccessioniPrimary (citable) accession number: A8H979
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.