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A8H8Z4 (FTHS_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Spea_3720
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087657

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H8Z4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: A5265CCF8F388332

FASTA57060,496
        10         20         30         40         50         60 
MHSDIEISRQ HTCLPITDIA NNLGLEPDEL SLCGANKAKI SLSVAKRLAD RENAKLVIVT 

        70         80         90        100        110        120 
AVTPTPFGEG KTVTTIGLTQ AMNLNGIKAC ACIRQPSMGP VFGTKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
ELNLHLTGDI HAVSSAHNLA AAAIDARLFH ETRLGAEAFT QESGLTALNI DAENILWRRV 

       190        200        210        220        230        240 
VDHNERSLRQ IKVGFGAVNG PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN 

       250        260        270        280        290        300 
NQGEPITAET LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI 

       310        320        330        340        350        360 
AAKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN SGIESDQDIN 

       370        380        390        400        410        420 
QPDTQRLKVG FANLEWHINN VSQYGVPVVV AINRFPTDTD EELEWLKQAI EQTKAFGSEI 

       430        440        450        460        470        480 
SEAFGKGAEG ATKLADMVYR ATQTPSDFNL LYESNTSLES KLMTLAEVGY GASSVTLSDK 

       490        500        510        520        530        540 
AKSQLNWLAK HNYGELPICV AKTPMSISHD PDIKGIPTGF ELPITELRLN AGAGFVTALV 

       550        560        570 
GKVMTMPGLG IKPGYLNVDI NDDGEIVGLA 

« Hide

References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000851 Genomic DNA. Translation: ABV89031.1.
RefSeqYP_001503566.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H8Z4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398579.Spea_3720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV89031; ABV89031; Spea_3720.
GeneID5664105.
KEGGspl:Spea_3720.
PATRIC23537621. VBIShePea72822_3882.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAAMTVIMS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSPEA398579:GHG5-3889-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEPA
AccessionPrimary (citable) accession number: A8H8Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways