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A8H8Z4

- FTHS_SHEPA

UniProt

A8H8Z4 - FTHS_SHEPA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-3889-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Spea_3720
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000087657Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398579.Spea_3720.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H8Z4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiAMTVIMS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8H8Z4-1 [UniParc]FASTAAdd to Basket

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    MHSDIEISRQ HTCLPITDIA NNLGLEPDEL SLCGANKAKI SLSVAKRLAD    50
    RENAKLVIVT AVTPTPFGEG KTVTTIGLTQ AMNLNGIKAC ACIRQPSMGP 100
    VFGTKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH 150
    ETRLGAEAFT QESGLTALNI DAENILWRRV VDHNERSLRQ IKVGFGAVNG 200
    PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN NQGEPITAET 250
    LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI 300
    AAKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN 350
    SGIESDQDIN QPDTQRLKVG FANLEWHINN VSQYGVPVVV AINRFPTDTD 400
    EELEWLKQAI EQTKAFGSEI SEAFGKGAEG ATKLADMVYR ATQTPSDFNL 450
    LYESNTSLES KLMTLAEVGY GASSVTLSDK AKSQLNWLAK HNYGELPICV 500
    AKTPMSISHD PDIKGIPTGF ELPITELRLN AGAGFVTALV GKVMTMPGLG 550
    IKPGYLNVDI NDDGEIVGLA 570
    Length:570
    Mass (Da):60,496
    Last modified:November 13, 2007 - v1
    Checksum:iA5265CCF8F388332
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV89031.1.
    RefSeqiYP_001503566.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV89031; ABV89031; Spea_3720.
    GeneIDi5664105.
    KEGGispl:Spea_3720.
    PATRICi23537621. VBIShePea72822_3882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV89031.1 .
    RefSeqi YP_001503566.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H8Z4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_3720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV89031 ; ABV89031 ; Spea_3720 .
    GeneIDi 5664105.
    KEGGi spl:Spea_3720.
    PATRICi 23537621. VBIShePea72822_3882.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi AMTVIMS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SPEA398579:GHG5-3889-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiFTHS_SHEPA
    AccessioniPrimary (citable) accession number: A8H8Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3