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A8H8Z4

- FTHS_SHEPA

UniProt

A8H8Z4 - FTHS_SHEPA

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Spea_3720
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3889-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Spea_3720
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000087657Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_3720.

Structurei

3D structure databases

ProteinModelPortaliA8H8Z4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiAMTVIMS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H8Z4-1 [UniParc]FASTAAdd to Basket

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MHSDIEISRQ HTCLPITDIA NNLGLEPDEL SLCGANKAKI SLSVAKRLAD    50
RENAKLVIVT AVTPTPFGEG KTVTTIGLTQ AMNLNGIKAC ACIRQPSMGP 100
VFGTKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH 150
ETRLGAEAFT QESGLTALNI DAENILWRRV VDHNERSLRQ IKVGFGAVNG 200
PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN NQGEPITAET 250
LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI 300
AAKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN 350
SGIESDQDIN QPDTQRLKVG FANLEWHINN VSQYGVPVVV AINRFPTDTD 400
EELEWLKQAI EQTKAFGSEI SEAFGKGAEG ATKLADMVYR ATQTPSDFNL 450
LYESNTSLES KLMTLAEVGY GASSVTLSDK AKSQLNWLAK HNYGELPICV 500
AKTPMSISHD PDIKGIPTGF ELPITELRLN AGAGFVTALV GKVMTMPGLG 550
IKPGYLNVDI NDDGEIVGLA 570
Length:570
Mass (Da):60,496
Last modified:November 13, 2007 - v1
Checksum:iA5265CCF8F388332
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV89031.1.
RefSeqiYP_001503566.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV89031; ABV89031; Spea_3720.
GeneIDi5664105.
KEGGispl:Spea_3720.
PATRICi23537621. VBIShePea72822_3882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV89031.1 .
RefSeqi YP_001503566.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H8Z4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_3720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV89031 ; ABV89031 ; Spea_3720 .
GeneIDi 5664105.
KEGGi spl:Spea_3720.
PATRICi 23537621. VBIShePea72822_3882.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi AMTVIMS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPEA398579:GHG5-3889-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiFTHS_SHEPA
AccessioniPrimary (citable) accession number: A8H8Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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