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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi11Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi87Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei212S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei262S-adenosyl-L-methionineUniRule annotation1
Binding sitei309S-adenosyl-L-methionineUniRule annotation1
Active sitei336NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSPEA398579:G1GA8-3879-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Ordered Locus Names:Spea_3635
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002608 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004148241 – 37823S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST378

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_3635

Structurei

3D structure databases

SMRiA8H8Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS Bacteria
COG2265 LUCA
HOGENOMiHOG000218547
KOiK03212
OrthoDBiPOG091H00VG

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR001566 23S_rRNA_MeTrfase_RlmD
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
TIGR00479 rumA, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8H8Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCAHFDQQQ CLSCRHIKQS MSVQVAAKSQ VLSQLLSDFE VEQWHEPVFG
60 70 80 90 100
PDSGFRNKAK MVVLGAAHQP ILGIVTPTGE PVSLCDCNLY PEDMQLLLHR
110 120 130 140 150
LEQFVRQAGI PPYNVDKAKG ELKFILLTRS QIKGEYLLRF VLKSHKSIER
160 170 180 190 200
IERELPKLLS EYPQIKVVSV NIQPVHMAIL EGEEEIFLTE ETRLSEQFND
210 220 230 240 250
VPLFIRPKSF FQTHPQIAAK LYQTAREWVA ELKPSSLWDL FCGVGGFGLH
260 270 280 290 300
CASKTIPLTG IEISSEAIAC AKISAETMGL TQVDFTALDS TGFAQGCDAT
310 320 330 340 350
DKPDVVIVNP PRRGIGESLC QSLSDFAPKA ILYSSCNPHT LAKDLANIQG
360 370
YHIQKVQLFD MFPHTDHFEV LVMLVKPS
Length:378
Mass (Da):42,277
Last modified:January 25, 2012 - v2
Checksum:i74FD3A97629C517F
GO

Sequence cautioni

The sequence ABV88946 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA Translation: ABV88946.1 Different initiation.
RefSeqiWP_041411099.1, NC_009901.1

Genome annotation databases

EnsemblBacteriaiABV88946; ABV88946; Spea_3635
KEGGispl:Spea_3635

Similar proteinsi

Entry informationi

Entry nameiRLMC_SHEPA
AccessioniPrimary (citable) accession number: A8H8Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: February 28, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome