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A8H8M9

- MURA_SHEPA

UniProt

A8H8M9 - MURA_SHEPA

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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donorUniRule annotation

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
  6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3773-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Short name:
EPTUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:Spea_3603
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420UDP-N-acetylglucosamine 1-carboxyvinyltransferasePRO_1000075984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_3603.

Structurei

3D structure databases

ProteinModelPortaliA8H8M9.
SMRiA8H8M9. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiHGLEQMG.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H8M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLKIEASG ALAGNVVISG AKNAALPILM AGVLAETDFN VSNVPNLRDV
60 70 80 90 100
NTSCELLRCL GAEVTRSGTD KVCISTTNLN EFCAPYDLVK TMRASILILG
110 120 130 140 150
PLLARYGTAD VSLPGGCAIG ARPVNLHLQG LEQMGAQIEV QEGYIKARVD
160 170 180 190 200
GRLKGAHIFM DMISVGATEN LLMAASLADG ETIIENAARE PEVVDLANCL
210 220 230 240 250
IAMGAKIEGA GTDTVRIQGV ESLQGCDYRV MPDRIETGSF LVAAAVTRGK
260 270 280 290 300
IRCTKADPKS LEAVLAKLED AGANITTGDD WIELDMQGKR PKAVNIKTVA
310 320 330 340 350
YPGFPTDMQA QFCVLNALAE GTATITETIF ENRFMHVPEL SRMGATMELE
360 370 380 390 400
GNTCIIHGIE RLNGAQVMAT DLRASASLVI AGLVAEGTTI VDRIYHLDRG
410 420
YEHIEDKFKG LGGHVERVKS
Length:420
Mass (Da):44,775
Last modified:November 13, 2007 - v1
Checksum:iFF8FBD13F96C168B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV88916.1.
RefSeqiYP_001503451.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV88916; ABV88916; Spea_3603.
GeneIDi5663989.
KEGGispl:Spea_3603.
PATRICi23537380. VBIShePea72822_3762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV88916.1 .
RefSeqi YP_001503451.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H8M9.
SMRi A8H8M9. Positions 1-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_3603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV88916 ; ABV88916 ; Spea_3603 .
GeneIDi 5663989.
KEGGi spl:Spea_3603.
PATRICi 23537380. VBIShePea72822_3762.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi HGLEQMG.
OrthoDBi EOG68M4GK.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SPEA398579:GHG5-3773-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiMURA_SHEPA
AccessioniPrimary (citable) accession number: A8H8M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3