Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8H8M9 (MURA_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:Spea_3603
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_1000075984

Sites

Active site1171Proton donor By similarity

Amino acid modifications

Modified residue11712-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H8M9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: FF8FBD13F96C168B

FASTA42044,775
        10         20         30         40         50         60 
MDKLKIEASG ALAGNVVISG AKNAALPILM AGVLAETDFN VSNVPNLRDV NTSCELLRCL 

        70         80         90        100        110        120 
GAEVTRSGTD KVCISTTNLN EFCAPYDLVK TMRASILILG PLLARYGTAD VSLPGGCAIG 

       130        140        150        160        170        180 
ARPVNLHLQG LEQMGAQIEV QEGYIKARVD GRLKGAHIFM DMISVGATEN LLMAASLADG 

       190        200        210        220        230        240 
ETIIENAARE PEVVDLANCL IAMGAKIEGA GTDTVRIQGV ESLQGCDYRV MPDRIETGSF 

       250        260        270        280        290        300 
LVAAAVTRGK IRCTKADPKS LEAVLAKLED AGANITTGDD WIELDMQGKR PKAVNIKTVA 

       310        320        330        340        350        360 
YPGFPTDMQA QFCVLNALAE GTATITETIF ENRFMHVPEL SRMGATMELE GNTCIIHGIE 

       370        380        390        400        410        420 
RLNGAQVMAT DLRASASLVI AGLVAEGTTI VDRIYHLDRG YEHIEDKFKG LGGHVERVKS 

« Hide

References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000851 Genomic DNA. Translation: ABV88916.1.
RefSeqYP_001503451.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H8M9.
SMRA8H8M9. Positions 1-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398579.Spea_3603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV88916; ABV88916; Spea_3603.
GeneID5663989.
KEGGspl:Spea_3603.
PATRIC23537380. VBIShePea72822_3762.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAGYEHIED.
OrthoDBEOG68M4GK.
ProtClustDBPRK09369.

Enzyme and pathway databases

BioCycSPEA398579:GHG5-3773-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_SHEPA
AccessionPrimary (citable) accession number: A8H8M9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways