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A8H819 (ADD_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:Spea_3392
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Adenosine deaminase HAMAP MF_00540
PRO_1000081933

Sites

Active site2001Proton donor By similarity
Metal binding121Zinc; catalytic By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding1971Zinc; catalytic By similarity
Metal binding2781Zinc; catalytic By similarity
Binding site141Substrate By similarity
Binding site161Substrate By similarity
Site2211Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H819 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: F19E96376FFA7338

FASTA33136,921
        10         20         30         40         50         60 
MNYLQLPKID LHCHLDGSVR PQTVIDLAKL QDVTIPSFNV DDIKALMVAP ASCPNLDEYL 

        70         80         90        100        110        120 
TRFALPVSVM QTEAALERIS FELFEDAAKE NVKYLEVRFG PQLHQKMSLN FEQIIGSVVK 

       130        140        150        160        170        180 
GMRRAEAQYD IKGNYILSII KVLPKDDIND VIDAGAKFLN NGVVAFDLAA SEEPGFCHEY 

       190        200        210        220        230        240 
IPYAKYALEK GYRITIHAGE QGVGQNVYDA ISLLGAERIG HGIHINSHQQ AYELVKTEAV 

       250        260        270        280        290        300 
ALETCPSSNV QTKAVESIES HPFGDFYRDG LLVTINTDNR TVSDTTMTKE LQLAAEKFNL 

       310        320        330 
TEADYFAIYK MSVDNAFTSD EVKLSLLKFI D

« Hide

References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000851 Genomic DNA. Translation: ABV88706.1.
RefSeqYP_001503241.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H819.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8H819.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5663779.
GenomeReviewsGene locus Spea_3392 in contig CP000851_GR.
KEGGspl:Spea_3392.
NMPDRfig|398579.3.peg.2929.
PATRIC23536930. VBIShePea72822_3543.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycSPEA398579:SPEA_3392-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_SHEPA
AccessionPrimary (citable) accession number: A8H819
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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