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A8H7S9

- GCSP_SHEPA

UniProt

A8H7S9 - GCSP_SHEPA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Spea_3301
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3465-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Spea_3301
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000083215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi398579.Spea_3301.

Structurei

3D structure databases

ProteinModelPortaliA8H7S9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H7S9-1 [UniParc]FASTAAdd to Basket

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MTTETLTQLE QHELFLRRHI GPGADQQQEM LNFVGAESLE DLTAQIVPGA    50
ILLNRDLAVG DSCGEAEGLA YIRKIADKNK VFKSYIGMGY HGTEVPSVIQ 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASSSLLD 150
EATAAAEAMA LSKRVSKAKK ANIFFVADDV FPQTIDVIKT RAECFGFEVV 200
VGPAEEAVNY ELFGALFQYT NRVGQICDHT ELFAKLHEKK ALVSVAADIM 250
SLVVLKSPGS MGADVVLGNS QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 300
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
FHGPQGLKVI AERIHRLTDI VAAALTAKGV ELVNNTWFDT LSIKGLDVTA 400
VQARALATGL NLRIDSDGVI GVSLSETTTR SDVAELFDVL LGEGHGQDAA 450
ALDAAIIANG SSSIPSELVR KDAILTHPTF NRYQSETEMM RYIKRLENKD 500
LALNHSMISL GSCTMKLNAA TEMAPITWPE FGNMHPFCPQ DQAQGYAQLL 550
EELSTWLVDI TGYDAVSLQP NSGAQGEYAG LLAIKQYHES RGDAHRNICL 600
IPQSAHGTNP ASAQLAGMKI VVTACDKAGN IDMADLKAKA AEVADNLSCI 650
MVTYPSTHGV YEETIGEICE VIHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKKH LAPFLSGHSV VKHGLESDNN 750
GAVSAAPFGS AGILPITWMY IKLLGKKGLR QSTQVALLNA NYVMKKLSAH 800
YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIEAMVSIR GEIAKVEAGE WPVDNNPLHN 900
APHTLADIMD PAFDSRPYSR EEAVFPTNAV KANKFWPTVN RIDDVYGDRN 950
LMCSCAPVSD YE 962
Length:962
Mass (Da):104,430
Last modified:November 13, 2007 - v1
Checksum:i25BD24D85912E0FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV88616.1.
RefSeqiYP_001503151.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV88616; ABV88616; Spea_3301.
GeneIDi5663689.
KEGGispl:Spea_3301.
PATRICi23536747. VBIShePea72822_3452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV88616.1 .
RefSeqi YP_001503151.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H7S9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_3301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV88616 ; ABV88616 ; Spea_3301 .
GeneIDi 5663689.
KEGGi spl:Spea_3301.
PATRICi 23536747. VBIShePea72822_3452.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SPEA398579:GHG5-3465-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiGCSP_SHEPA
AccessioniPrimary (citable) accession number: A8H7S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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