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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3465-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Spea_3301
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000083215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi398579.Spea_3301.

Structurei

3D structure databases

ProteinModelPortaliA8H7S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H7S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFLRRHI GPGADQQQEM LNFVGAESLE DLTAQIVPGA
60 70 80 90 100
ILLNRDLAVG DSCGEAEGLA YIRKIADKNK VFKSYIGMGY HGTEVPSVIQ
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASSSLLD
160 170 180 190 200
EATAAAEAMA LSKRVSKAKK ANIFFVADDV FPQTIDVIKT RAECFGFEVV
210 220 230 240 250
VGPAEEAVNY ELFGALFQYT NRVGQICDHT ELFAKLHEKK ALVSVAADIM
260 270 280 290 300
SLVVLKSPGS MGADVVLGNS QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
FHGPQGLKVI AERIHRLTDI VAAALTAKGV ELVNNTWFDT LSIKGLDVTA
410 420 430 440 450
VQARALATGL NLRIDSDGVI GVSLSETTTR SDVAELFDVL LGEGHGQDAA
460 470 480 490 500
ALDAAIIANG SSSIPSELVR KDAILTHPTF NRYQSETEMM RYIKRLENKD
510 520 530 540 550
LALNHSMISL GSCTMKLNAA TEMAPITWPE FGNMHPFCPQ DQAQGYAQLL
560 570 580 590 600
EELSTWLVDI TGYDAVSLQP NSGAQGEYAG LLAIKQYHES RGDAHRNICL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMKI VVTACDKAGN IDMADLKAKA AEVADNLSCI
660 670 680 690 700
MVTYPSTHGV YEETIGEICE VIHQHGGQVY LDGANMNAQV GLTSPGFIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKKH LAPFLSGHSV VKHGLESDNN
760 770 780 790 800
GAVSAAPFGS AGILPITWMY IKLLGKKGLR QSTQVALLNA NYVMKKLSAH
810 820 830 840 850
YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIEAMVSIR GEIAKVEAGE WPVDNNPLHN
910 920 930 940 950
APHTLADIMD PAFDSRPYSR EEAVFPTNAV KANKFWPTVN RIDDVYGDRN
960
LMCSCAPVSD YE
Length:962
Mass (Da):104,430
Last modified:November 12, 2007 - v1
Checksum:i25BD24D85912E0FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV88616.1.
RefSeqiYP_001503151.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV88616; ABV88616; Spea_3301.
KEGGispl:Spea_3301.
PATRICi23536747. VBIShePea72822_3452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000851 Genomic DNA. Translation: ABV88616.1.
RefSeqiYP_001503151.1. NC_009901.1.

3D structure databases

ProteinModelPortaliA8H7S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398579.Spea_3301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV88616; ABV88616; Spea_3301.
KEGGispl:Spea_3301.
PATRICi23536747. VBIShePea72822_3452.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3465-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiGCSP_SHEPA
AccessioniPrimary (citable) accession number: A8H7S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: November 12, 2007
Last modified: March 31, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.