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A8H7S9 (GCSP_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Spea_3301
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083215

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H7S9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 25BD24D85912E0FD

FASTA962104,430
        10         20         30         40         50         60 
MTTETLTQLE QHELFLRRHI GPGADQQQEM LNFVGAESLE DLTAQIVPGA ILLNRDLAVG 

        70         80         90        100        110        120 
DSCGEAEGLA YIRKIADKNK VFKSYIGMGY HGTEVPSVIQ RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASSSLLD EATAAAEAMA LSKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTIDVIKT RAECFGFEVV VGPAEEAVNY ELFGALFQYT NRVGQICDHT ELFAKLHEKK 

       250        260        270        280        290        300 
ALVSVAADIM SLVVLKSPGS MGADVVLGNS QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 

       310        320        330        340        350        360 
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV FHGPQGLKVI 

       370        380        390        400        410        420 
AERIHRLTDI VAAALTAKGV ELVNNTWFDT LSIKGLDVTA VQARALATGL NLRIDSDGVI 

       430        440        450        460        470        480 
GVSLSETTTR SDVAELFDVL LGEGHGQDAA ALDAAIIANG SSSIPSELVR KDAILTHPTF 

       490        500        510        520        530        540 
NRYQSETEMM RYIKRLENKD LALNHSMISL GSCTMKLNAA TEMAPITWPE FGNMHPFCPQ 

       550        560        570        580        590        600 
DQAQGYAQLL EELSTWLVDI TGYDAVSLQP NSGAQGEYAG LLAIKQYHES RGDAHRNICL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQLAGMKI VVTACDKAGN IDMADLKAKA AEVADNLSCI MVTYPSTHGV 

       670        680        690        700        710        720 
YEETIGEICE VIHQHGGQVY LDGANMNAQV GLTSPGFIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKKH LAPFLSGHSV VKHGLESDNN GAVSAAPFGS AGILPITWMY IKLLGKKGLR 

       790        800        810        820        830        840 
QSTQVALLNA NYVMKKLSAH YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESESKVELD RFIEAMVSIR GEIAKVEAGE WPVDNNPLHN 

       910        920        930        940        950        960 
APHTLADIMD PAFDSRPYSR EEAVFPTNAV KANKFWPTVN RIDDVYGDRN LMCSCAPVSD 


YE 

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References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000851 Genomic DNA. Translation: ABV88616.1.
RefSeqYP_001503151.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H7S9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398579.Spea_3301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV88616; ABV88616; Spea_3301.
GeneID5663689.
KEGGspl:Spea_3301.
PATRIC23536747. VBIShePea72822_3452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSPEA398579:GHG5-3465-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEPA
AccessionPrimary (citable) accession number: A8H7S9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families