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A8H7S9

- GCSP_SHEPA

UniProt

A8H7S9 - GCSP_SHEPA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-3465-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Spea_3301
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000083215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi398579.Spea_3301.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H7S9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8H7S9-1 [UniParc]FASTAAdd to Basket

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    MTTETLTQLE QHELFLRRHI GPGADQQQEM LNFVGAESLE DLTAQIVPGA    50
    ILLNRDLAVG DSCGEAEGLA YIRKIADKNK VFKSYIGMGY HGTEVPSVIQ 100
    RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASSSLLD 150
    EATAAAEAMA LSKRVSKAKK ANIFFVADDV FPQTIDVIKT RAECFGFEVV 200
    VGPAEEAVNY ELFGALFQYT NRVGQICDHT ELFAKLHEKK ALVSVAADIM 250
    SLVVLKSPGS MGADVVLGNS QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 300
    IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
    FHGPQGLKVI AERIHRLTDI VAAALTAKGV ELVNNTWFDT LSIKGLDVTA 400
    VQARALATGL NLRIDSDGVI GVSLSETTTR SDVAELFDVL LGEGHGQDAA 450
    ALDAAIIANG SSSIPSELVR KDAILTHPTF NRYQSETEMM RYIKRLENKD 500
    LALNHSMISL GSCTMKLNAA TEMAPITWPE FGNMHPFCPQ DQAQGYAQLL 550
    EELSTWLVDI TGYDAVSLQP NSGAQGEYAG LLAIKQYHES RGDAHRNICL 600
    IPQSAHGTNP ASAQLAGMKI VVTACDKAGN IDMADLKAKA AEVADNLSCI 650
    MVTYPSTHGV YEETIGEICE VIHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKKH LAPFLSGHSV VKHGLESDNN 750
    GAVSAAPFGS AGILPITWMY IKLLGKKGLR QSTQVALLNA NYVMKKLSAH 800
    YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKVELD RFIEAMVSIR GEIAKVEAGE WPVDNNPLHN 900
    APHTLADIMD PAFDSRPYSR EEAVFPTNAV KANKFWPTVN RIDDVYGDRN 950
    LMCSCAPVSD YE 962
    Length:962
    Mass (Da):104,430
    Last modified:November 13, 2007 - v1
    Checksum:i25BD24D85912E0FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88616.1.
    RefSeqiYP_001503151.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV88616; ABV88616; Spea_3301.
    GeneIDi5663689.
    KEGGispl:Spea_3301.
    PATRICi23536747. VBIShePea72822_3452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88616.1 .
    RefSeqi YP_001503151.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H7S9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_3301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV88616 ; ABV88616 ; Spea_3301 .
    GeneIDi 5663689.
    KEGGi spl:Spea_3301.
    PATRICi 23536747. VBIShePea72822_3452.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SPEA398579:GHG5-3465-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiGCSP_SHEPA
    AccessioniPrimary (citable) accession number: A8H7S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3